Improvement of solubility of celecoxib by inclusion in MCM-41 mesoporous silica: drug loading and release

Günaydin, Şahika; Yılmaz, Ali Özgür

doi:10.3906/kim-1409-56

Cited by 22 publications

(10 citation statements)

References 31 publications

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“…The formation method of mesoporous materials adopted from Günaydin and Yilmaz and modified from [21,22]. Boron-silica based mesoporous (BMCM) was prepared using the sol-gel technique.…”

Section: Formation Of Boron-silica Based Mesoporousmentioning

confidence: 99%

Boron-Silica Based Mesoporous for Curcuminoid Isolation From Turmeric Extract

et al. 2020

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Objective: The purpose of this study was to develop the isolation method for curcuminoid from turmeric extract using boron-silica based mesoporous as an adsorbent. Methods: The formation of mesoporous materials were conducted using the sol-gel technique. The characterization of mesoporous materials was analyzed using a scanning electron microscope (SEM), transmission electron microscope (TEM), and Fourier transforms infrared spectrometry (FTIR). The extraction of turmeric was done by solvent extraction using ethanol 96 %. The isolation of curcuminoid was achieved by the adsorption method using mesoporous materials, both for silica-based mesoporous (MCM) and boron-silica based mesoporous (BMCM). The elution of curcuminoid-loaded mesoporous was conducted using various solvents. The concentration of total curcuminoid and its compounds was measured by visible spectrometry and high-performance liquid chromatography (HPLC). Results: Morphology of MCM and BMCM shows the homogenous regular spherical shape, but having a different size. MCM has a smaller diameter particle size (500-600 nm) compared to BMCM (700-900 nm). On the other hand, BMCM has a smaller pore size (1-5 nm) compared to MCM (5-20 nm). The FTIR spectra of BMCM shows the additional vibration at 1400-1600 cm for B-O-H bond. Visible spectrometry measurement shows that the highest concentration of curcuminoid eluted from BMCM is 65.411±0.056 ppm by using ethyl acetate as a solvent, while the concentration of curcuminoid eluted from MCM is 11.503±0.054 ppm by using the same solvent. The results of curcuminoid adsorption and elution, indicating that ethyl acetate is the best solvent to elute curcuminoid due to its 98.83 % purity using HPLC analysis. Conclusion: It was concluded that boron-silica based mesoporous showed stronger curcuminoid adsorption than silica-based mesoporous therefore found to be a potential adsorbent for curcuminoid isolation from turmeric extract.

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“…The formation method of mesoporous materials adopted from Günaydin and Yilmaz and modified from [21,22]. Boron-silica based mesoporous (BMCM) was prepared using the sol-gel technique.…”

Section: Formation Of Boron-silica Based Mesoporousmentioning

confidence: 99%

Boron-Silica Based Mesoporous for Curcuminoid Isolation From Turmeric Extract

et al. 2020

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“…In recent years, drug delivery systems (DDSs) are widely investigated by researchers owing to their numerous advantages, such as minimizing the side effects of drugs, better targeting, and cost-effectiveness [1]. Various sustained-release systems have been developed to adopt an effectively controlled drug-release, including but not limited to particulate carriers, lipids, polymeric films, and gels [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of boric acid-crosslinked ethyl cellulose and polyvinyl alcohol films as potential drug release systems for topical drug delivery

Aliasgharlou¹,

Sana²,

Khoshbakht³

et al. 2020

Turk J Chem

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In this study, boric acid (BA) is employed as a crosslinking agent to improve the characteristics of two commonly used polymeric films, ethyl cellulose (EC) and polyvinyl alcohol (PVA), for topical drug delivery applications. The developed films are characterized by FTIR spectroscopy and SEM analysis. The results show that the surfaces of the prepared films are even and transparent, except for the BA-modified EC sample. The initial cumulative release for erythromycin (EM) is found to be 0.30 and 0.36 mg/mL for EC and PVA films, which drops to 0.25 and 0.20 mg/mL after BA crosslinking, respectively, after 1 h at 25 °C. Further, the developed formulations are stable for 75 days. Also, the antibacterial activity of the developed formulations is investigated against S. aureus (ATCC® 25923™ and ATCC® 29213™). The obtained data confirm that the application of BA as the crosslinking agent extends the release of EM from EC and PVA polymeric films. The findings of this study suggest that BA-crosslinked EC and PVA films are promising carriers for controlled topical drug delivery applications.

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“…The high specific surface area (>1000 m 2 /g), large pore volume (~ 1.0-2.0 cm 3 /g), and consequently the high sorption/hosting capacity for bioactive molecules, the relative simple, inexpensive, environmentally friendly and controllable synthesis procedure, the biocompatibility and lack of toxicity, explain the particular interest reflected in a large number of publications worldwide. Thus, pure or modified MCM-41 mesoporous silica was used as carrier for various types of drugs, such as ibuprofen, 6 aspirin, 7,8 naproxen, 9 doxorubicin, 10 captopril, 11 erythromycin, 12 celecoxib, 13 econazole nitrate, 14 famotidine, 15 mesalazine, 16 tetracycline, 17 alendronate, 18,19 curcumin, 20,21 folic acid, 22 etc. More information can be found in exhaustive investigation on drug release from silica-based ordered mesoporous materials, reported by Maria Vallet-Regi et.…”

Section: Introductionmentioning

confidence: 99%

Development of New Bexarotene-loaded Mesoporous Silica Systems for Topical Pharmaceutical Formulations

Vasile

Ignat

Zaltariov

et al. 2018

ACSi

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The present study reports the first time use of MCM-41 mesoporous silica as highly efficient carrier for bexarotene -an antineoplastic agent specific for cutaneous T-cell lymphoma treatment. Bexarotene is highly toxic and poor-water soluble, having low bioavailability in the conventional pharmaceutical forms. Comparative uptake of bexarotene on amino-functionalized silica host at various functionalization degrees is discussed in details taking into account all structural features, of matrix as well as properties of the drug molecules. The obtained results proved a successful bexarotene loading on amino-functionalized MCM-41 silica. The bexarotene molecules are adsorbed on the active centers in non-crystalline state proving the major role of the silica amino-functionalization for the drug solubility and bioavailability enhancing. In vitro dissolution tests showed a prolonged release of bexarotene during 12 h, reaching 50% release of loaded active molecules. The prolonged release has been demonstrated to be a result of the presence of aminopropyl groups on the silica pore walls.

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Improvement of solubility of celecoxib by inclusion in MCM-41 mesoporous silica: drug loading and release

Cited by 22 publications

References 31 publications

Boron-Silica Based Mesoporous for Curcuminoid Isolation From Turmeric Extract

Boron-Silica Based Mesoporous for Curcuminoid Isolation From Turmeric Extract

Fabrication and characterization of boric acid-crosslinked ethyl cellulose and polyvinyl alcohol films as potential drug release systems for topical drug delivery

Development of New Bexarotene-loaded Mesoporous Silica Systems for Topical Pharmaceutical Formulations

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