Improvement of Skin Quality after Fat Grafting: Clinical Observation and an Animal Study

Mojallal, Ali; Lequeux, Charlotte; Shipkov, Christo; Breton, P.; Foyatier, J.-L.; Braye, F.; Damour, O.

doi:10.1097/prs.0b013e3181b17b8f

Cited by 230 publications

(112 citation statements)

References 22 publications

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“…The mean percentage of scar improvement between before-and after-treatment quantitative assessments showed that autologous fat transfer is more effective in improving ice-pick scars and there were no significant differences in the total number of scars from fractional CO 2 laser for rolling and boxcar scars. Previous histologic and immunohistologic studies demonstrated a large difference in results between fat grafting and fractional ablative CO 2 laser for the treatment of acne scars, and favored fat grafting [35] . Histologic and immunohistologic experimental study compared biopsies taken from nude mice before and after fat graft, and showed an increased density of extracellular matrix surrounding the fatty tissue and between the fatty tissue and the dermis [32] .…”

Section: Discussionmentioning

confidence: 99%

Fractional ablative CO2 laser treatment versus scar subcision and autologous fat transfer in the treatment of atrophic acne scars: New technique

Mohammad

Elgarhy

Saad³

et al. 2016

J Surg Dermatol

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There are different modalities for management of atrophic acne scars which include lasers. Ablative fractional CO 2 laser was developed to address the shortcomings of traditional ablative lasers, with superior results to non-ablative fractional lasers. Autologous fat transfer has been utilized for nearly a decade in tissue augmentation and reconstruction. Present studies were designed to compare ablative fractional CO 2 laser treatment with scar subcision and autologous fat transfer in the treatment of atrophic acne scars. 20 patients with atrophic acne scars were recruited: 10 patients were treated by three sessions of ablative fractional CO 2 laser therapy, and 10 patients treated by subcision and autologous fat transfer. All patients were followed up for three months, and were assessed by digital photograph before and after treatment through the application of Goodman and Baron quantitative and qualitative grading systems, in addition to reports by three physicians committees and reports of patients' satisfaction. Analysis of both groups showed significant improvements in all types of atrophic acne scars. The mean percentage of total quantitative improvement was more significant in the case of autologous fat transfer with regard to ice-pick and total number of scars. Therefore, scar subcision with autologous fat transfer proved to be as effective as, or even more effective than, ablative fractional CO 2 laser in the treatment of atrophic acne scars with regard to the total number of scars as well as ice-pick type.Keywords: Acne scars; laser; fat transfer Citation: Mohammad LM, Elgarhy LH, Saad DG, Mostafa WA. Fractional ablative CO 2 laser treatment versus scar subcision and autologous fat transfer in the treatment of atrophic acne scars: New technique.

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Section: Discussionmentioning

confidence: 99%

Fractional ablative CO2 laser treatment versus scar subcision and autologous fat transfer in the treatment of atrophic acne scars: New technique

Mohammad

Elgarhy

Saad³

et al. 2016

J Surg Dermatol

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“…Face is an ideal recipient site with rich blood supply which acts as an optimal scaffold, yielding a high percentage take of transplanted adipose cells [11]. An article by Mojallal et al [19] examined the effects of human fat transfer in mice from a clinical and histologic level. The authors found that the transplanted fat stimulated a ''regenerative effect'' on the overlying skin resulting in increased pore diameter and overall elasticity.…”

Section: Discussionmentioning

confidence: 99%

A New Minimally Invasive Aesthetic Procedure for Correction of Frontal Coup de Sabre Deformity in Romberg’s Syndrome

Agrawal

Desai

Choudhary

et al. 2014

J. Maxillofac. Oral Surg.

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“…Fat grafting is the author's preference due to many reasons: the fat is abundant, the procedure is autologous, fat grafting is a cell transplant which has anti-inflammatory "anti-fibrotic" and "trophic" effects with a possibility of achieving better skin quality, and the results are natural [25][26][27] . In literature, there is no difference in clinical results regarding the donor site, the use of anesthetic agents, vasoconstrictors, negative pressure, harvested fat process methods (centrifugation, decanting, washing, etc.)…”

Section: Discussionmentioning

confidence: 99%

Tear trough – Anatomy and treatment by autologous fat grafting

Chia

2016

J Surg Dermatol

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Tear trough is the main irregularity at midface, of which treatment is difficult. There is no agreement in literature about its anatomy and best treatment. The author presented an anatomical study and personal autologous fat grafting technique for tear trough treatment. Anatomical dissections were done on two fresh cadavers to examine the skin, subcutaneous, muscle and bone layers, spaces, and attachments. Safety and efficacy were evaluated via retrospective analysis of the last 200 consecutive procedures performed by the author. Tear trough is caused by the abrupt transition of the palpebral orbicular oculi muscle (OOM) (i.e., thin skin without subcutaneous fat compartment) to the orbital OOM (i.e., thicker skin with malar fat compartment). The tear trough region is located at the OOM bony origin at the medial canthus where no specific ligament was found. The grafted fat volume stabilized at two or three months after the procedure, instead of six months as stated in literature, with excellent results and no severe complications. Tear trough is a personal characteristic, a natural anatomical depression caused by subcutaneous irregularity and can worsen with age. The lack of volume is not effectively corrected by surgeries and thus it must be filled. Fat grafting has several advantages over alloplastic fillers, although it may be more difficult. Fat graft is autologous and abundant, and tissue transplantation could enhance skin quality. Fat grafting is a simple, safe, and effective solution for adding extra volume to correct the deflation phenomenon of the midface aging process. There is no specific anatomical plane for volume injection; the fat graft must be evenly distributed in the deep and superficial plane for uniformity.

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Improvement of Skin Quality after Fat Grafting: Clinical Observation and an Animal Study

Abstract: This study shows that fat tissue grafting stimulates a neosynthesis of collagen fibers at the recipient site and makes the dermis thicker. However, the long-term effects remain undetermined and need further investigation.

Cited by 230 publications

References 22 publications

Fractional ablative CO2 laser treatment versus scar subcision and autologous fat transfer in the treatment of atrophic acne scars: New technique

Fractional ablative CO2 laser treatment versus scar subcision and autologous fat transfer in the treatment of atrophic acne scars: New technique

A New Minimally Invasive Aesthetic Procedure for Correction of Frontal Coup de Sabre Deformity in Romberg’s Syndrome

Tear trough – Anatomy and treatment by autologous fat grafting

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