Improvement of Refractory Chronic Actinic Dermatitis During Tofacitinib Treatment

Wang, Yingjun; Hui, Hai-Zhen; Cheng, Jia-Rong; Mao, Han; Diao, Qingchun; Shi, Bing-Jun

doi:10.1097/mjt.0000000000001616

Cited by 1 publication

(1 citation statement)

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“…Subsequently, after the administration of tofacitinib, there was a remission of symptoms without the presence of adverse effects. 22 The patient in our study also used first-line drugs for their condition, such as topical glucocorticoid ointments, loratadine, cetirizine, and other antihistamines. However, these results were unexpected.…”

Section: Discussionmentioning

confidence: 96%

Successful Treatment of Chronic Actinic Dermatitis with Tofacitinib

Zhong,

Ali,

Yang

et al. 2024

CCID

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We present the case of a 58-year-old male patient who presented with pruritic skin plaques and papules on the scalp, face, back, and back of the hands for over a year. The symptoms worsened upon exposure to sunlight and improved on cloudy days. Despite previous attempts at treatment with glucocorticoid ointment and antihistamine drugs, the patient experienced progressive aggravation of symptoms. Physical examination revealed hypertrophic and infiltrating nodules, with significant scratches and local exudation. Skin biopsy confirmed the diagnosis of sun-induced dermatosis. The patient was initiated on tofacitinib, an oral Janus Kinase inhibitor, along with a halometasone ointment, oral ebastine tablets, and strict sun protection. Over the course of four revisits spanning four months, the patient experienced a significant improvement in symptoms, with the rash almost disappearing and pruritus subsiding. The treatment was well tolerated and no adverse effects were observed. Follow-up for six months post-treatment showed no recurrence of symptoms. This case highlights the efficacy of tofacitinib in managing sun-induced pruritic plaques and suggests it as a potential therapeutic option in similar cases.

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Section: Discussionmentioning

confidence: 96%