Improvement of Ocular Blood Flow and Retinal Functions with Puerarin Analogs

Xuan, Bo; Zhou, Yue; Yang, Rua-Lin; Li, Na; Min, Zhi-Da; Chiou, George C.Y.

doi:10.1089/jop.1999.15.207

Cited by 59 publications

(27 citation statements)

References 11 publications

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“…OHWI. 27) As a result of its ability to lower intraocular pressure, and improve ocular blood flow, it is frequently used as a therapeutic agent for cataracta glauca and ocular hypertension in China. However, due to its poor solubility and permeability across biomembrane, there also exist problems such as lower bioavailability and systemic absorption which were common questions of most eye drops.…”

mentioning

confidence: 99%

Effect of Poly(amidoamine) Dendrimers on Corneal Penetration of Puerarin

Yao

Sun

Liu

et al. 2010

Biological & Pharmaceutical Bulletin

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The aim of this study was to investigate the effect of Poly(amidoamine) (PAMAM) dendrimers on corneal permeation of puerarin (PUE). Permeation studies were performed using excised cornea of rabbits by a Valia-Chien diffusion apparatus. Drug-treatment studies were carried out by measuring the penetration of puerarin on cornea in PAMAM-PUE physical mixture or PAMAM-PUE complex, and cornea-treatment studies were carried out by measuring the penetration of puerarin on PAMAM dendrimer pretreated cornea in puerarin solution. The results showed that the permeability coefficient of puerarin in PAMAM-PUE physical mixture was enhanced by 2.48 (G3), 1.99 (G4) and 1.36 (G5) times on average, respectively compared to control. However, no significant permeability enhancement of puerarin in PAMAM-PUE complex was found compared to control. This may attribute to free drug concentration was lower in PAMAM-PUE complex which served as a depot and exhibited slow-released behavior of drug. Cornea-treatment studies showed that the lag time of puerarin was decreased, while the cumulative amount within 2.5 h (Q 2.5 ) and the permeability coefficient of puerarin increased compared to control. The permeability coefficient of puerarin was linear correlated to the molecular weight of PAMAM dendrimer (r 2 ‫.)99.0؍‬ This indicates that higher generation of PAMAM dendrimer more easily interact with cornea or loosen the epithelium cell junctions than lower generation to increase the flux of puerarin. Overall, the study showed that PAMAM dendrimer increased the corneal permeation of puerarin mainly by altering the corneal barrier.

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confidence: 99%

Effect of Poly(amidoamine) Dendrimers on Corneal Penetration of Puerarin

Yao

Sun

Liu

et al. 2010

Biological & Pharmaceutical Bulletin

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“…6) In particular, it has long been used to treat cardiovascular diseases including coronary artery diseases (CAD), 7) arrhythmia 8) and hypertension. 9) Moreover, some studies of the mechanisms of puerarin on CAD have shown that, for example, puerarin could recovery left ventricular function and increase coronary blood flow.…”

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Puerarin Induces Angiogenesis in Myocardium of Rat with Myocardial Infarction

Zhang

Chen

Yingjun

et al. 2006

Biological & Pharmaceutical Bulletin

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Puerarin is a major effective ingredient extracted from the traditional Chinese medicine Ge-gen (Radix Puerariae, RP). Recently, puerarin has been used to treat patients with coronary artery diseases (CAD). However, the mechanisms of puerarin on coronary artery diseases are still not very clear. In this study, we investigated the role of puerarin on angiogenesis in the non-ischemic and ischemic myocardium. We found that puerarin (120, 60 mg/kg, i.p.) could reduce infarct area in the heart of rat with myocardial infarction (MI). Puerarin (120 mg/kg) induced angiogenesis in the non-ischemic and ischemic myocardium, which was one of the mechanisms of curing coronary artery diseases. The gene expression or activation of vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1a a (HIF-1a a) and endothelial nitric oxide synthase (eNOS) that correlated with angiogenesis were also induced by puerarin. From these results, we suggested that puerarin may induce therapeutic angiogenesis in myocardium of rat with MI. The mechanism may be that puerarin can induce VEGF and eNOS expression.Key words angiogenesis; puerarin; myocardial infarction; vascular endothelial growth factor (VEGF); endothelial nitric oxide synthase (eNOS); hypoxia-inducible factor 1a (HIF-1a)

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“…Puerarin (Pue, Figure 1B) is a type of an isoflavone derivative and the main active ingredient of the Pueraria lobata (Willd) Ohwi root [4] . Pue can significantly lower blood sugar levels, decrease serum total cholesterol and improve ocular blood flow in clinical applications [5][6][7][8][9] . Pue can also increase CYP7A1 mRNA expression, which reduced the atherogenic properties of dietary cholesterol in rats [6] .…”

Section: Introductionmentioning

confidence: 99%

Absorptive interactions of concurrent oral administration of (+)-catechin and puerarin in rats and the underlying mechanisms

Lin

Wang

et al. 2016

Acta Pharmacol Sin

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Aim: (+)-Catechin and puerarin are polyphenol and flavonoid, respectively, in green tea and foodstuffs. They exhibit potent antioxidant activity and are widely used for treating cardiocerebrovascular diseases. The aim of this work was to investigate the potential interactions between (+)-catechin and puerarin following concurrent oral administration in rats, and their absorption mechanisms in Caco-2 cell monolayers. Methods: Pharmacokinetic studies were conducted in male rats received (+)-catechin (140 mg/kg, po) and/or puerarin (200 mg/kg, po). The cell uptake and transport behavior in Caco-2 cell monolayers and the interactions of the two compounds were analyzed. Results: When (+)-catechin and puerarin were administered concurrently, the AUC 0-12 h and C max values of puerarin were 2.48-fold and 3.91-fold, respectively, as large as those of puerarin alone; the AUC 0-12 h and C max values of (+)-catechin were decreased to 57.62% and 77.55%, respectively, compared with those of (+)-catechin alone. In Caco-2 cell monolayers, (+)-catechin (300 and 600 μmol/L) significantly increased the cell uptake and transport of puerarin, whereas puerarin (300 and 600 μmol/L) significantly decreased the cellular uptake and transport of (+)-catechin. Furthermore, both cyclosporine A (P-glycoprotein inhibitor) and MK-571 (MRP-2 inhibitor) significantly increased the cellular uptake and transport of (+)-catechin and puerarin. Conclusion: Concurrent oral administration of (+)-catechin and puerarin significantly increased the absolute oral bioavailability of puerarin, but decreasing that of (+)-catechin. The competitive efflux of (+)-catechin and puerarin by P-glycoprotein and MRP-2 might lead to this interaction during their absorption process in the small intestine.

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Improvement of Ocular Blood Flow and Retinal Functions with Puerarin Analogs

Cited by 59 publications

References 11 publications

Effect of Poly(amidoamine) Dendrimers on Corneal Penetration of Puerarin

Effect of Poly(amidoamine) Dendrimers on Corneal Penetration of Puerarin

Puerarin Induces Angiogenesis in Myocardium of Rat with Myocardial Infarction

Absorptive interactions of concurrent oral administration of (+)-catechin and puerarin in rats and the underlying mechanisms

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