Puerarin Induces Angiogenesis in Myocardium of Rat with Myocardial Infarction

Zhang, Sanyin; Chen, Shilin; Yingjun, Shen; Yang, Da; Liu, Xijing; Sun-chi, Albert Chan; Xu, Hong‐Xi

doi:10.1248/bpb.29.945

Cited by 96 publications

(60 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[29][30][31] The previous study found that Puerarin may induce therapeutic angiogenesis in myocardium by inducing VEGF and eNOS expression in myocardium of rat with myocardial infarction. 32,33 It would scavenge free radicals, lower serum cholesterol, and have antithrombotic and antiallergic activities. From the present results, we suggested that Puerarin-treated animals had a significantly decreased eNOS expression in glomerular and tubular cells under diabetes condition.…”

Section: Discussionmentioning

confidence: 99%

The Puerarin improves renal function in STZ-induced diabetic rats by attenuating eNOS expression

Zhang

Wang

et al. 2015

Renal Failure

View full text Add to dashboard Cite

Diabetic nephropathy (DN) is a serious complication and it leads to kidney failure. The endothelial nitric oxide synthases (eNOS) seems to be involved in the development and progression of DN. The Puerarin is a well-known Chinese traditional formula, which is widely used in clinical practice for the treatment of kidney disease. The present study was designed to investigate the renal protective effects of Puerarin on streptozotocin (STZ)-induced diabetic rats. Thirty Sprague-Dawley (SD) male rats were divided into three groups at random. The diabetic group and the Puerarin-treated group were intraperitoneally injected with STZ 65 mg/kg and the Puerarin-treated rats were intraperitoneally injected Puerarin 100 mg/kg/day for 4 weeks. The results showed the Puerarin could improve body weight, blood sugar, BUN and SCr levels, and reduce ultrastructural changes of kidney in diabetic rats. It also attenuated eNOS expression in glomerular endothelial cells and tubular cells of diabetic rats with Puerarin treatment (p50.05). The Puerarin had significant renal-protective effects for the diabetic nephropathy, possibly through regulating eNOS expression, and it may be used as a potential therapeutic reagent.

show abstract

Section: Discussionmentioning

confidence: 99%

The Puerarin improves renal function in STZ-induced diabetic rats by attenuating eNOS expression

Zhang

Wang

et al. 2015

Renal Failure

View full text Add to dashboard Cite

show abstract

“…An association between puerarin and VEGF has been reported in several studies, and puerarin has been suggested to suppress the vascularization of ectopic endometrial tissues stimulated by 17β-estradiol (Wang et al, 2011) and to inhibit VEGF expression in retinas of streptozotocin-induced early diabetic rats (Chen et al, 2012a). Other reports suggest that puerarin may induce therapeutic angiogenesis by increasing VEGF mRNA expression in rats with myocardial infarction (Zhang et al, 2006). The discrepant effects of PR on VEGF expression may possibly be due to differences in species and disease types.…”

Section: Journal Of Agricultural Sciencementioning

confidence: 95%

Suppressive Effects of Puerariae Radix on the Breast Tumor Incidence in Rats Treated with DMBA

Chen¹,

Wu²,

Tseng³

et al. 2017

JAS

View full text Add to dashboard Cite

Puerariae Radix (PR) is the root of Pueraria lobata, an herb widely used in traditional Chinese medicine and as a food seasoning. Owing to its potential anti-oxidative ability, the effects of PR on the inhibition of breast tumors were investigated in this study using the 7,12-dimethylbenz[a]anthracene (DMBA)-treated rat model. Thirty-two female Sprague-Dawley rats were randomly assigned to one of four different treatment groups, with or without PR and/or DMBA administration. At the age of 177 days, all rats were sacrificed, the number and size of tumors were recorded, and blood and tissue samples were collected for assessment of hematological parameters, redox status, and tumorigenesis-related factors. We found that PR supplementation decreased tumor incidence and WBC count but increased the IgM levels, and significantly altered the redox status, elevated serum TGF-β levels, and reduced serum VEGF-C and ICAM-1 levels. The mechanism by which PR decreased the incidence of DMBA-induced rat breast tumors might include ameliorating immunity, enhancing the antioxidant status, increasing the hepatic excretion of carcinogenic metabolites of DMBA, and influencing the expression of tumorigenesis-related factors.

show abstract

“…Howe). Puerarin is widely prescribed for patients with cardio-cerebrovascular diseases in China and it has been reported to have therapeutic effects on hypertension, 1 cerebral ischemia, 2 myocardial ischemia, 3 diabetes mellitus, 4 metabolic syndrome, 5 and arteriosclerosis. 6 The molecular mechanism underlying these pharmacological benefits is believed to involve puerarin's ability to act as an antioxidant and a scavenger of reactive oxygen species.…”

Section: Introductionmentioning

confidence: 99%

Metabolic profile of puerarin in rats after intragastric administration of puerarin solid lipid nanoparticles

Luo¹,

Hou²,

Jun³

et al. 2013

IJN

View full text Add to dashboard Cite

Puerarin has multiple pharmacological effects and is widely prescribed for patients with cardiovascular diseases including hypertension, cerebral ischemia, myocardial ischemia, diabetes mellitus, and arteriosclerosis. We have successfully prepared puerarin-loaded solid lipid nanoparticles (Pue-SLNs) for oral administration. Pue-SLNs are prepared using monostearin, soya lecithin, and poloxamer 188. SLNs may alter the course of puerarin absorption predominantly to and through lymphatic routes and regions, presumably following a transcellular path of lipid absorption, especially by enterocytes and polar epithelial cells of the intestine. The alteration of absorption might influence the metabolic profile of puerarin when incorporated into SLNs. In the present study, we investigated the metabolic profile of puerarin in rat plasma and urine using rapid resolution liquid chromatography-tandem mass spectrometry after a single-dose intragastric administration of Pue-SLNs in comparison with puerarin suspension. Two glucuronidated metabolites of puerarin, puerarin-4′-O-glucuronide and puerarin-7-Oglucuronide, were detected in rat plasma and urine after intragastric administration of Pue-SLNs, with the latter acting as the major metabolite. Similar results were found in rat plasma and urine after intragastric administration of puerarin suspension. The results suggest that incorporation of puerarin into SLNs does not change either the position of glucuronidation or the metabolic pathway of puerarin in rats.

show abstract

Puerarin Induces Angiogenesis in Myocardium of Rat with Myocardial Infarction

Cited by 96 publications

References 32 publications

The Puerarin improves renal function in STZ-induced diabetic rats by attenuating eNOS expression

The Puerarin improves renal function in STZ-induced diabetic rats by attenuating eNOS expression

Suppressive Effects of Puerariae Radix on the Breast Tumor Incidence in Rats Treated with DMBA

Metabolic profile of puerarin in rats after intragastric administration of puerarin solid lipid nanoparticles

Contact Info

Product

Resources

About