Improvement of mortality prediction accuracy in critically ill patients through combination of SOFA and APACHE II score with markers of stress haematopoiesis

Abstract

Assessment of organ failure and mortality risk in critically ill patients is possible through Systemic Organ Failure Assessment (SOFA) and APACHE II scores. According to the results of prospective studies, 1-3 higher SOFA score is associated with increased mortality. APACHE II score is based on 17 physical and laboratory parameters as well as from data on personal history. 4,5

Prognostic impacts of peripheral blood erythroblasts after single‐unit cord blood transplantation

“…Similar to previous studies in patients undergoing HCT 11,12 and other critically ill patients, [1][2][3][4][5][6][7] erythroblastosis is a predictor of early mortality in adult patients who underwent single-unit CBT.…”

“…Erythroblasts (EBLs), also known as nucleated red blood cells, are progenitor cells of erythroid lineage and are not typically detected in peripheral blood (PB) under steady‐state conditions; however, EBLs have been observed in PB during a variety of serious conditions, such as critically ill status, 1‐7 neonatal disorders, 8‐10 sepsis, 2,6,8,9 and post‐hematopoietic cell transplantation (HCT) 11,12 . Several studies have indicated that the presence of higher levels of EBLs in PB may adversely affect survival in patients with serious conditions, including allogeneic HCT 1‐7,10‐12 …”

“…11,12 Several studies have indicated that the presence of higher levels of EBLs in PB may adversely affect survival in patients with serious conditions, including allogeneic HCT. [1][2][3][4][5][6][7][10][11][12] Cord blood transplantation (CBT) is an established alternative donor source for patients who require allogeneic HCT when a human leukocyte antigen (HLA)-matched donor is unavailable. [13][14][15][16][17] EBLs in…”

Prognostic Value of Nucleated RBCs for Patients With Suspected Sepsis in the Emergency Department: A Single-Center Prospective Cohort Study

“…To our knowledge, our study is the first to demonstrate the predictive value of NRBCs at a single measurement point at hospital admission. Previous studies from the ICU setting have classified patients into NRBC positive or negative by using NRBC results from the whole ICU stay and, in some cases, analyzed the predictive value using the highest NRBCs during the ICU stay ( 10 , 12 , 13 ).…”

“…Currently, circulating NRBCs can be measured reliably by some automated hematology analyzers at very low concentrations ( 11 ), and this development has opened renewed interest in NRBCs as a potential prognostic biomarker. Studies have described an association between circulating NRBCs and mortality in ICU patients ( 10 , 12 , 13 ), mortality after hospital discharge for ICU patients ( 14 ), and for mortality in ICU patients with surgical sepsis ( 15 ) and ARDS ( 16 ). However, most of these studies have analyzed the highest NRBC value found during the admittance, which is not necessarily useful as a predictor early in the admission.…”