Usefulness of sequential organ failure assessment score on admission to predict the 90-day mortality in patients with exertional heatstroke: An over 10-year intensive care survey

Wu, Ming; Zhong, Li; Ji, Jingjing; Liu, Zhifeng

doi:10.1016/j.ajem.2022.08.042

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…Severe heatstroke patients often develop RM, possibly due to disrupted thermoregulatory center function and loss of water, electrolytes, and membrane channel integrity under prolonged high temperature and thermal radiation, affecting skeletal muscle energy metabolism [16]. Clinically, RM is frequently associated with AKI, attributed to reduced renal perfusion from effective circulatory volume depletion, potentially causing ischemic rhabdomyocyte necrosis and subsequent renal tubular obstruction [17,18].…”

Section: Discussionmentioning

confidence: 99%

Predictive value of serum myoglobin and lactate dehydrogenase in rhabdomyolysis-induced acute kidney injury from severe heatstroke

Yin

2024

Am J Transl Res

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Objective: To explore the predictive utility of serum myoglobin (Mb) and lactate dehydrogenase (LDH) for acute kidney injury (AKI) secondary to rhabdomyolysis (RM) in severe heatstroke patients. Methods: A retrospective analysis of 58 RM patients with severe heatstroke at Shanghai Ninth People's Hospital from June 2019 to May 2022 was conducted. Patients were categorized into AKI and non-AKI groups. Laboratory indices were compared, and receiver operating characteristic (ROC) curves were used to assess the predictive value of serum biomarkers for AKI. Results: Creatine kinase, Mb, LDH, creatinine, and blood urea nitrogen levels were significantly higher in the AKI group (P<0.05). Serum Mb and LDH were positively correlated with serum creatinine (r=0.6772 and r=0.6816, respectively; P<0.05). The area under the ROC curve (AUC) for serum Mb was 0.6692 (95% CI: 0.5253-0.8131) with a cut-off of 1024 ng/ml, while for LDH it was 0.8277 (95% CI: 0.7182-0.9371) with a cut-off of 1342 U/L. Combining serum Mb and LDH improved the AUC to 0.9116 (95% CI: 0.8219-1.001). Conclusion: Serum Mb and LDH levels are elevated in RM-induced AKI following severe heatstroke, and their combination offers substantial predictive value for AKI in these patients.

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Section: Discussionmentioning

confidence: 99%

Predictive value of serum myoglobin and lactate dehydrogenase in rhabdomyolysis-induced acute kidney injury from severe heatstroke

Yin

2024

Am J Transl Res

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“…CHS = classic heat stroke, DIC = disseminated intravascular coagulation, EHS = exertional heat stroke, GCS = Glasgow Coma Score, HR = heart rate, J-ERATO score = Early Risk Assessment Tool for Detecting Clinical Outcomes in Patients with Heat-related Illness, RR = respiratory rate, SBP = systolic blood pressure, SOFA = sequential organ failure assessment. Data from references: (25, 36, 77, 83, 86–90).…”

Section: Clinical Managementmentioning

confidence: 99%

Management of Heat-Related Illness and Injury in the ICU: A Concise Definitive Review

Barletta,

Palmieri,

Toomey

et al. 2024

Critical Care Medicine

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Objectives: The increasing frequency of extreme heat events has led to a growing number of heat-related injuries and illnesses in ICUs. The objective of this review was to summarize and critically appraise evidence for the management of heat-related illnesses and injuries for critical care multiprofessionals. Data Sources: Ovid Medline, Embase, Cochrane Clinical Trials Register, Cumulative Index to Nursing and Allied Health Literature, and ClinicalTrials.gov databases were searched from inception through August 2023 for studies reporting on heat-related injury and illness in the setting of the ICU. Study Selection: English-language systematic reviews, narrative reviews, meta-analyses, randomized clinical trials, and observational studies were prioritized for review. Bibliographies from retrieved articles were scanned for articles that may have been missed. Data Extraction: Data regarding study methodology, patient population, management strategy, and clinical outcomes were qualitatively assessed. Data Synthesis: Several risk factors and prognostic indicators for patients diagnosed with heat-related illness and injury have been identified and reported in the literature. Effective management of these patients has included various cooling methods and fluid replenishment. Drug therapy is not effective. Multiple organ dysfunction, neurologic injury, and disseminated intravascular coagulation are common complications of heat stroke and must be managed accordingly. Burn injury from contact with hot surfaces or pavement can occur, requiring careful evaluation and possible excision and grafting in severe cases. Conclusions: The prevalence of heat-related illness and injury is increasing, and rapid initiation of appropriate therapies is necessary to optimize outcomes. Additional research is needed to identify effective methods and strategies to achieve rapid cooling, the role of immunomodulators and anticoagulant medications, the use of biomarkers to identify organ failure, and the role of artificial intelligence and precision medicine.

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Prognostic significance of nadir platelet count in patients with heatstroke: A multi-center retrospective study

Chen,

Liu,

et al. 2024

The American Journal of Emergency Medicine

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Usefulness of sequential organ failure assessment score on admission to predict the 90-day mortality in patients with exertional heatstroke: An over 10-year intensive care survey

Cited by 5 publications

References 30 publications

Predictive value of serum myoglobin and lactate dehydrogenase in rhabdomyolysis-induced acute kidney injury from severe heatstroke

Predictive value of serum myoglobin and lactate dehydrogenase in rhabdomyolysis-induced acute kidney injury from severe heatstroke

Management of Heat-Related Illness and Injury in the ICU: A Concise Definitive Review

Prognostic significance of nadir platelet count in patients with heatstroke: A multi-center retrospective study

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