Improvement of leucocyte functions in ovariectomised aged rats after treatment with growth hormone, melatonin, oestrogens or phyto-oestrogens

Baeza, Isabel; Alvarado, Carmen; Álvarez, Pedro; Salazar, Verónica; Castillo, Carmen; Ariznavarreta, C.; Fdez-Tresguerres, Jesús; Fuente, Mónica De la

doi:10.1016/j.jri.2009.02.002

Cited by 25 publications

(15 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In conclusion, the present study shows that ovariectomy, which causes serious damage in the normal functioning of nervous system, liver metabolism, vascular activity, immune system and skin (Castillo et al 2006;Kireev et al 2007;Baeza et al 2009), is also directly linked to a pro-oxidative state. The administration of hormonal replacement therapies with GH, MEL and OE, as well as with PE, might be advisable to reinforce the anti-oxidant defences and to decrease the levels of oxidant compounds and the associated damages in liver, heart, kidney and spleen.…”

Section: General Conclusionmentioning

confidence: 60%

“…The present work is part of a multicenter project study in which the effects of ovariectomy and ageing, as well as the effect of different chronic hormonal treatments, have been evaluated on several organs and systems, such as Central Nervous System (CNS), vascular function, hepatocytes, bone, skin and immune function Pérez-Martín et al 2005;Castillo et al 2005Castillo et al , 2006Baeza et al 2009). In the present study it has been investigated whether recombinant human growth hormone (rhGH), melatonin (MEL), oestrogens (OE) or phytoestrogens (PE) administration regimes were able to improve the altered redox state and the peroxidative damage which characterizes the old age and is aggravated by ovariectomy.…”

Section: Experimental Design and Hormonal Treatmentsmentioning

confidence: 99%

“…Possible candidates for the beneficial actions of soybean compounds are isoflavones, such as genistein and daidzein, since they show a structural similarity to oestradiol (Rachoń et al 2006). Recent work from our group has found that these compounds stimulate key immune functions in ovariectomized mice (Baeza et al 2007(Baeza et al , 2009. They may also function as antioxidants by enhancing antioxidant enzyme activity (Viña et al 2008).…”

Section: Phytoestrogensmentioning

confidence: 99%

See 2 more Smart Citations

Effects of growth hormone, melatonin, oestrogens and phytoestrogens on the oxidized glutathione (GSSG)/reduced glutathione (GSH) ratio and lipid peroxidation in aged ovariectomized rats

et al. 2010

View full text Add to dashboard Cite

Ovariectomy constitutes a commonly used model in rats and mice for human menopause. After ovariectomy, an imbalance between oxidant production and antioxidant levels appears in favour of the former, with increased oxidative stress and consequently an acceleration of ageing. In the present work, the levels of reduced glutathione (GSH), a relevant antioxidant, and oxidized glutathione (GSSG), an oxidant compound, as well as lipid peroxidation (through malondialdehyde (MDA) levels), were studied in liver, heart, kidney and spleen homogenates of old (24 months of age) unovariectomized and ovariectomized female Wistar rats. The results showed a significant increase of the GSSG/GSH ratio, a marker of oxidative stress, and higher MDA production in all the studied organs of ovariectomized rats as compared with unovariectomized animals. These data confirm the idea that ovariectomy accelerates the ageing process. Administration of growth hormone (GH), melatonin (MEL) and oestrogens (OE), as well as soybean phytoestrogens (PE) for 10 weeks, between 22 and 24 months of age, was able to decrease oxidative stress in the investigated organs of ovariectomized old rats, therefore slowing down the ageing process in those animals.

show abstract

Section: General Conclusionmentioning

confidence: 60%

Section: Experimental Design and Hormonal Treatmentsmentioning

confidence: 99%

Section: Phytoestrogensmentioning

confidence: 99%

See 1 more Smart Citation

Effects of growth hormone, melatonin, oestrogens and phytoestrogens on the oxidized glutathione (GSSG)/reduced glutathione (GSH) ratio and lipid peroxidation in aged ovariectomized rats

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Previous studies published by our research group have described that ovariectomy results in a premature ageing of functions in rat leukocytes from spleen and axillary nodes (De la Fuente et al 2004a;Baeza et al 2009), as well as in a premature ageing of the nervous system assessed through sensorimotor and anxiety-like behavioural tests (Baeza et al 2010a). Moreover, ovariectomy also causes an accelerated imbalance between oxidant production and antioxidant levels in favour of the former, with resulting oxidative stress in spleen, liver, heart and kidney cells .…”

Section: Introductionmentioning

confidence: 87%

Ovariectomy causes immunosenescence and oxi-inflamm-ageing in peritoneal leukocytes of aged female mice similar to that in aged males

et al. 2011

View full text Add to dashboard Cite

Immunosenescence involves age-associated restructuring changes of innate and adaptative immune functions. We have suggested that these changes of the immune system participate in the rate of ageing through modulating oxi-inflamm-ageing. Thus, age-related changes in the immune system can be biological age markers and predictors of longevity. Gender differences in oxidation status and immune functions have been observed in rats, with males showing higher oxidation and immunosenescence than females of the same age. Oestrogens are sex hormones that actively participate in modulating the mammalian immune function and, therefore, the age-related impairment of the immune response is drastically accelerated in females during the menopausal transition. Ovariectomy in rodents constitutes a good model for mimicking human oestrogen loss and thus the menopausal situation. Recently, we have shown the deleterious effects of oestrogen loss on several functions of leukocytes from immune organs in rats and mice. In addition, ovariectomised rats show similar levels in these immune functions to those in males. The present work studied several functions as well as inflammatory and oxidative stress parameters in mouse peritoneal macrophages and lymphocytes from old sham and ovariectomised females, as well as in males of the same age. In general, the results show that females, which have a higher immune response and a lower oxidation and inflammation than males, appear similar to males in the parameters studied when they have lost oestrogens by ovariectomy. Thus, these data support the positive role of oestrogens in the immune function through the ageing process.

show abstract

“…Sodhi y Tripathi (19), en estudios in vitro donde investigaron el perfil de citoquinas secretadas por macrófagos cuando eran tratados con GH y PRL, reportan que ambas hormonas mejoraron significativamente la producción de citoquinas tales como interleuquina-1β (IL-1β), interleuquina-12p40 (IL-12p40) e IFNg , además, indujeron la producción de quimoquinas como proteína inflamatoria de macrófagos-1 beta (MIP-1β por sus siglas en inglés macrophage inflammatory protein). Baeza et al (20), en sus estudios en ratas macho encontraron que la terapia con GH mejora las funciones del SI, en otro estudio, Baeza et al (21), utilizando ratas ovariectomizadas y enteras demostraron que la administración de GH, melatonina y estrógenos, estimulan la linfoproliferación en ambos grupos, además de ser efectivos para estimular los niveles de IL-2 y la actividad de las células asesinas (Naturall Killer NK), Asimismo, recientemente Frare et al (22), en un estudio in vivo utilizando ratas macho infectados con Trypanosoma cruzi, reportaron que animales tratados con GH muestran menor cantidad de tripomastigotes en sangre que ratas no tratadas y que las tratadas con GH tienden a producir altas concentraciones de factor de necrosis tumoral alfa (TNF-α), IFNg y óxido nítrico comparado con las ratas no tratadas, sugiriendo que GH puede ser considerada como una sustancia inmunomoduladora para controlar la replicación de parásitos.…”

Section: Introductionunclassified

Comunicación bidireccional entre el sistema inmune y neuroendocrino a través de la hormona de crecimiento, prolactina y hepcidina

Enríquez

2013

Rev MVZ Córdoba

View full text Add to dashboard Cite

RESUMENSe ha planteado que la hormona de crecimiento (GH) y la Prolactina (PRL) pueden intervenir en procesos infecciosos como inmunomoduladores vía receptores específicos; revelando una conexión entre el sistema inmune y el sistema endocrino en los tejidos, donde actúan como citoquinas a través de diferentes rutas de señalización. Igualmente, la hepcidina (HAMP), hormona producida en los hepatocitos como respuesta al exceso de hierro y a estímulos inflamatorios, es considerada un enlace entre el metabolismo del mineral, la defensa del hospedero y los procesos inflamatorios, debido a su capacidad de privar del hierro a los microorganismos. Se sugiere que en un proceso infeccioso, la síntesis, secreción y regulación de GH ocurre a través de la producción de citoquinas como factor de necrosis tumoral alfa (TNF-α) e interleuquina-1 beta (IL-1β), las cuales actúan en el hipotálamo, estimulando la liberación ya sea de la hormona liberadora de somatotropina o de somatostatina; por otro lado, se ha reportado que células linfoides, incluyendo linfocitos T y B y células dendríticas, producen GH, PRL biológicamente activa con propiedades inmunoreguladoras.Palabras clave: Hormona de crecimiento animal, prolactina, sistema inmune (Fuente:CAB). ABSTRACTIt has been proposed that growth hormone (GH) and prolactin (PRL) may act as immunomodulators in infectious processes via specific receptors, revealing a connection between the immune and endocrine systems in the tissues where they act as cytokines through different signaling pathways. Similarly, hepcidin (HAMP), a hormone produced in hepatocytes in response to excess iron and inflammatory stimuli, is considered a link between mineral metabolism, host defense and inflammatory processes because of its ability to deprive microorganisms of iron. It is suggested that in an infectious process, synthesis, and regulation of GH secretion occurs through the production of cytokines such as necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β), which act in the hypothalamus by stimulating the release of either somatostatin or somatotropin hormones; on the other hand, it has been reported that lymphoid cells including T and B lymphocytes and dendritic cells produce GH, and biologically active PRL with immunoregulatory properties.

show abstract

Improvement of leucocyte functions in ovariectomised aged rats after treatment with growth hormone, melatonin, oestrogens or phyto-oestrogens

Cited by 25 publications

References 35 publications

Effects of growth hormone, melatonin, oestrogens and phytoestrogens on the oxidized glutathione (GSSG)/reduced glutathione (GSH) ratio and lipid peroxidation in aged ovariectomized rats

Effects of growth hormone, melatonin, oestrogens and phytoestrogens on the oxidized glutathione (GSSG)/reduced glutathione (GSH) ratio and lipid peroxidation in aged ovariectomized rats

Ovariectomy causes immunosenescence and oxi-inflamm-ageing in peritoneal leukocytes of aged female mice similar to that in aged males

Comunicación bidireccional entre el sistema inmune y neuroendocrino a través de la hormona de crecimiento, prolactina y hepcidina

Contact Info

Product

Resources

About