Improvement of learning processes following chronic systemic administration of modafinil in mice

Béracochéa, Daniel; Célérier, Aurélie; Borde, Nathalie; Valleau, Magalie; Pérès, M.; Piérard, Christophe

doi:10.1016/s0091-3057(02)00877-8

Cited by 42 publications

(25 citation statements)

References 25 publications

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“…There is further evidence that modafinil enhances learning processes after chronic (Béracochéa et al, 2002) or acute (Béracochéa et al, 2003) systemic administration in mice. To the best of our knowledge, very few studies investigated the effect of modafinil administration on memory and/or neural activity after sleep deprivation.…”

Section: Introductionmentioning

confidence: 89%

Modafinil restores memory performance and neural activity impaired by sleep deprivation in mice

Piérard

Liscia

Philippin

et al. 2007

Pharmacology Biochemistry and Behavior

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Abstract:The original aims of our study have been to investigate in sleep-deprived mice, the effects of modafinil administration on spatial working memory, in parallel with the evaluation of neural activity level, as compared to non sleep-deprived animals. For this purpose, an original sleepdeprivation apparatus was developed and validated with continuous electroencephalography recording. Memory performance was evaluated using spontaneous alternation in a T-maze, whereas the neural activity level was estimated by the quantification of the c-Fos protein in various cerebral zones. This study allowed altogether:First, to evidence that a diurnal 10-hr sleep deprivation period induced an impairment of spatial working memory.Second, to observe a decrease in c-Fos expression after sleep deprivation followed by a behavioural test, as compared to non sleep-deprived mice. This impairment in neural activity was evidenced in areas involved in wake-sleep cycle regulation (anterior hypothalamus and supraoptic nucleus), but also in memory (frontal cortex and hippocampus) and emotions (amygdala).Finally, to demonstrate that modafinil 64 mg/kg is able to restore on the one hand memory performance after a 10-hr sleep deprivation period, and on the other hand, the neural activity level in the very same brain areas where it was previously impaired by sleep deprivation and cognitive task.

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Section: Introductionmentioning

confidence: 89%

Modafinil restores memory performance and neural activity impaired by sleep deprivation in mice

Piérard

Liscia

Philippin

et al. 2007

Pharmacology Biochemistry and Behavior

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“…These high-frequency components have been reported to be associated with the presentation of meaningful stimuli, with attentional processes and voluntary movements, and have been suggested to represent a correlate of cognition and synaptic plasticity (Canolty et al, 2006;Crone et al, 2006;Gray and Singer, 1989;Sanes and Donoghue, 1993;Tiitinen et al, 1993;Traub et al, 2005). The enhanced gamma activity observed during druginduced wakefulness might thus reflect heightened cognitive performance and, at least for modafinil, an increase in working memory has been demonstrated in mice (Beracochea et al, 2001(Beracochea et al, , 2002(Beracochea et al, , 2003Pierard et al, 2006) and rats (Miller et al, 2000;Ward et al, 2004). Other corroborating observations come from the increased c-FOS activity in the hippocampus of B6 mice, which was largest for the drug that also induced the largest increase in gamma activity; that is YKP10A.…”

Section: Drug Effects On the Waking Eegmentioning

confidence: 98%

How to Keep the Brain Awake? The Complex Molecular Pharmacogenetics of Wake Promotion

Hasan

Pradervand

Ahnaou³

et al. 2009

Neuropsychopharmacol

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Wake-promoting drugs are widely used to treat excessive daytime sleepiness. The neuronal pathways involved in wake promotion are multiple and often not well characterized. We tested d-amphetamine, modafinil, and YKP10A, a novel wake-promoting compound, in three inbred strains of mice. The wake duration induced by YKP10A and d-amphetamine depended similarly on genotype, whereas opposite strain differences were observed after modafinil. Electroencephalogram (EEG) analysis during drug-induced wakefulness revealed a transient B2 Hz slowing of theta oscillations and an increase in beta-2 (20-35 Hz) activity only after YKP10A. Gamma activity (35-60 Hz) was induced by all drugs in a drug-and genotype-dependent manner. Brain transcriptome and clustering analyses indicated that the three drugs have both common and specific molecular signatures. The correlation between specific EEG and gene-expression signatures suggests that the neuronal pathways activated to stay awake vary among drugs and genetic background.

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“…Recent studies have demonstrated that modafinil is able to improve working memory both in animals (Béracochéa et al 2001) as well as in humans (Muller et al 2004); there is further evidence that modafinil enhances learning processes after chronic (Béracochéa et al 2002) or acute (Béracochéa et al 2003) systemic administration in mice. These memory-enhancing effects of modafinil (see also Turner et al 2003), in addition to neuroprotective properties against hypoxia (Lagarde et al 1993) and organophosphate intoxication (Lallement et al 1997), could be partly mediated by the involvement of excitatory amino acids neurotransmission systems .…”

Section: Introductionmentioning

confidence: 97%

Stress modulation of the memory retrograde-enhancing effects of the awakening drug modafinil in mice

Béracochéa

Liscia²,

Tronche

et al. 2007

Psychopharmacology

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Results showed that: (1) stress significantly improved performance in vehicles, (2) stress decreased the efficiency threshold of modafinil, as performance was enhanced at the low dose (16 mg/kg), whereas this enhancement was obtained for the high dose (32 mg/kg) under nonstress conditions, (3) the performance was impaired at the high (32 mg/kg) dose, and (4) modafinil significantly reduced the magnitude of the stress-induced corticosterone secretion, mainly at the dose of 32 mg/kg.

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Improvement of learning processes following chronic systemic administration of modafinil in mice

Cited by 42 publications

References 25 publications

Modafinil restores memory performance and neural activity impaired by sleep deprivation in mice

Modafinil restores memory performance and neural activity impaired by sleep deprivation in mice

How to Keep the Brain Awake? The Complex Molecular Pharmacogenetics of Wake Promotion

Stress modulation of the memory retrograde-enhancing effects of the awakening drug modafinil in mice

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