Modafinil restores memory performance and neural activity impaired by sleep deprivation in mice

Piérard, Christophe; Liscia, Pierrette; Philippin, J. N.; Mons, Nicole; Lafon, Thierry; Chauveau, Frédéric; VANBEERS, P; Drouet, Isabelle; Serra, A; Jouanin, Jean-Claude

doi:10.1016/j.pbb.2007.07.006

Cited by 57 publications

(50 citation statements)

References 45 publications

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“…To the best of our knowledge, only our previous study has already shown that modafinil induced a retrograde memory-enhancing effect (Béracochéa et al 2003;Pierard et al 2007). More specifically, it was found that modafinil induced a faster emergence of a learning set rule, according to the amount of training (1 or 4 days) occurring before the injection.…”

Section: Behavioural Effects Of Modafinil In Rodents Tasksmentioning

confidence: 84%

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Stress modulation of the memory retrograde-enhancing effects of the awakening drug modafinil in mice

Béracochéa

Liscia²,

Tronche

et al. 2007

Psychopharmacology

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Results showed that: (1) stress significantly improved performance in vehicles, (2) stress decreased the efficiency threshold of modafinil, as performance was enhanced at the low dose (16 mg/kg), whereas this enhancement was obtained for the high dose (32 mg/kg) under nonstress conditions, (3) the performance was impaired at the high (32 mg/kg) dose, and (4) modafinil significantly reduced the magnitude of the stress-induced corticosterone secretion, mainly at the dose of 32 mg/kg.

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Section: Behavioural Effects Of Modafinil In Rodents Tasksmentioning

confidence: 84%

“…We recently showed that modafinil is able to restore neural activity and memory performance previously impaired by sleep deprivation in mice (Pierard et al 2007). Because modafinil was administered after sleep deprivation, this last result evidenced the retrograde effect of modafinil on memory retrieval.…”

Section: Introductionmentioning

confidence: 99%

Stress modulation of the memory retrograde-enhancing effects of the awakening drug modafinil in mice

Béracochéa

Liscia²,

Tronche

et al. 2007

Psychopharmacology

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“…Thus, 6 h SD preceding acquisition of a water maze task impaired spatial memory in rats tested 24 h later, although it had not affected the learning curve during acquisition (Guan et al 2004), and a 10 h SD preceding a spontaneous alternation test impaired spatial working memory in mice (Pierard et al 2007). In human subjects a night of SD prior to learning, caused a deficit in the ability to encode new episodic memories, resulting in a worsening in retention (Yoo et al 2007).…”

Section: Introductionmentioning

confidence: 92%

Sleep Deprivation in the Dark Period Does Not Impair Memory in OF1 Mice

Palchykova

Winsky‐Sommerer

Tobler

2009

Chronobiology International

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There is increasing evidence that sleep facilitates memory acquisition and consolidation. Moreover, the sleep-wake history preceding memory acquisition and retention as well as circadian timing may be important. We showed previously that sleep deprivation (SD) following learning in OF1 mice impaired their performance in an object recognition task. The learning task was scheduled at the end of the 12-h dark period and the test 24 h later. To investigate the influence of the prominent circadian sleep-wake distribution typical for rodents, we now scheduled the learning task at the beginning of the dark period.Wakefulness following immediately after the learning task, was attained either by gentle interference (SD; n = 20) or by spontaneous wheel running (RW; n = 20).Two control groups were used. One had no RW throughout the experiment (n = 23), while the other group's wheel was blocked immediately after acquisition (n = 16), thereby preventing its use until test. Recognition memory, defined as the difference in exploration of a novel and familiar objects, was assessed 24 h later during the test phase. Motor activity and RW use were continuously recorded.Remarkably, performance in the object recognition task was not influenced by the protocols; the waking period following acquisition did not impair memory, independently of the method inducing wakefulness, i.e. sleep deprivation or spontaneous running. Thus, all groups explored the novel object significantly longer than the familiar ones during the test phase. Interestingly, neither the amount of rest lost during the SD interventions nor the amount of rest preceding acquisition influenced performance. However, the total amount of rest obtained 3 by the control and SD mice subjected to acquisition at "dark offset" correlated positively (r = 0.66) with memory at test, while no such relationship occurred in the corresponding groups tested at dark onset. Neither the amount of running nor intermediate rest correlated with performance at test in the RW group.We conclude that interfering with sleep during the dark period does not affect object recognition memory consolidation.

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“…Moreover, recent research from rodent experiments has highlighted that sleep deprivation is associated with reduced neural activity within brain regions involved in memory (frontal cortex and hippocampus), emotion (amygdala), and regulation of the sleep-wake cycle (anterior hypothalamus and supraoptic nucleus) (Pierard et al 2007;Vecsey et al 2009;Hagwoud et al 2011). Disruption of any of these distinct facets of cognition by sleep deprivation may contribute to noteworthy errors in decision-making (reviewed by (Killgore 2010)).…”

Section: Sleep Deprivation Affects Higher-order Cognitive Processesmentioning

confidence: 99%

Adenosine, Caffeine, and Performance: From Cognitive Neuroscience of Sleep to Sleep Pharmacogenetics

Urry

Landolt

2014

Current Topics in Behavioral Neurosciences

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An intricate interplay between circadian and sleep-wake homeostatic processes regulate cognitive performance on specific tasks, and individual differences in circadian preference and sleep pressure may contribute to individual differences in distinct neurocognitive functions. Attentional performance appears to be particularly sensitive to time of day modulations and the effects of sleep deprivation. Consistent with the notion that the neuromodulator, adenosine adenosine , plays an important role in regulating sleep pressure, pharmacologic and genetic data in animals and humans demonstrate that differences in adenosinergic tone affect sleepiness, arousal and vigilant attention attention in rested and sleep-deprived states. Caffeine Caffeine -the most often consumed stimulant in the world-blocks adenosine receptors and normally attenuates the consequences of sleep deprivation on arousal, vigilance, and attention. Nevertheless, caffeine cannot substitute for sleep, and is virtually ineffective in mitigating the impact of severe sleep loss on higher-order cognitive functions. Thus, the available evidence suggests that adenosinergic mechanisms, in particular adenosine A2A receptor-mediated signal transduction, contribute to waking-induced impairments of attentional processes, whereas additional mechanisms must be involved in higher-order cognitive consequences of sleep deprivation. Future investigations should further clarify the exact types of cognitive processes affected by inappropriate sleep. This research will aid in the quest to better understand the role of different brain systems (e.g., adenosine and adenosine receptors) in regulating sleep, and sleep-related subjective state, and cognitive processes. Furthermore, it will provide more detail on the underlying mechanisms of the detrimental effects of extended wakefulness, as well as lead to the development of effective, evidence-based countermeasures against the health consequences of circadian misalignment and chronic sleep restriction. In press (accepted): January 14, 2014 Addresses for correspondence:Hans-Peter Landolt, Ph.D.

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Modafinil restores memory performance and neural activity impaired by sleep deprivation in mice

Cited by 57 publications

References 45 publications

Stress modulation of the memory retrograde-enhancing effects of the awakening drug modafinil in mice

Stress modulation of the memory retrograde-enhancing effects of the awakening drug modafinil in mice

Sleep Deprivation in the Dark Period Does Not Impair Memory in OF1 Mice

Adenosine, Caffeine, and Performance: From Cognitive Neuroscience of Sleep to Sleep Pharmacogenetics

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