Improvement of in vitro corrosion and cytocompatibility of biodegradable Fe surface modified by Zn ion implantation

Wang, Henan; Zheng, Yang; Li, Yan; Jiang, Chengbao

doi:10.1016/j.apsusc.2017.01.158

Cited by 27 publications

(24 citation statements)

References 32 publications

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“…Huang et al reported that Zn ions, implanted by a metal vapour vacuum arc in Fe, accelerated the degradation rate of the iron [ 67 ]. Also, Wang et al used the ion implantation technique to inject Zn onto the surface of biodegradable, pure Fe [ 143 ]. In both examples, corrosion resistance decreased in comparison with pure iron and caused pitting corrosion.…”

Section: Iron Materials Modificationsmentioning

confidence: 99%

Biodegradable Iron-Based Materials—What Was Done and What More Can Be Done?

2021

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Iron, while attracting less attention than magnesium and zinc, is still one of the best candidates for biodegradable metal stents thanks its biocompatibility, great elastic moduli and high strength. Due to the low corrosion rate, and thus slow biodegradation, iron stents have still not been put into use. While these problems have still not been fully resolved, many studies have been published that propose different approaches to the issues. This brief overview report summarises the latest developments in the field of biodegradable iron-based stents and presents some techniques that can accelerate their biocorrosion rate. Basic data related to iron metabolism and its biocompatibility, the mechanism of the corrosion process, as well as a critical look at the rate of degradation of iron-based systems obtained by several different methods are included. All this illustrates as the title says, what was done within the topic of biodegradable iron-based materials and what more can be done.

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Section: Iron Materials Modificationsmentioning

confidence: 99%

Biodegradable Iron-Based Materials—What Was Done and What More Can Be Done?

2021

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“…In the past several decades, biodegradable metallic materials have served as one of the most promising strategies in regenerative medicine [ [1] , [2] , [3] , [4] ]. Biodegradable metals possess excellent mechanical properties, providing sufficient temporary support to resist the applied load, while the potential risk of long-term complications is effectively eliminated through the progressive degradation of the metals in the body [ 1 , [5] , [6] , [7] , [8] , [9] ]. Therefore, biodegradable metallic implants are best suited for the purposes of stabilizing fractured bone tissue and guiding bone healing.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have demonstrated that Fe possesses better mechanical performance than most metals and exhibits no local or systemic toxicity in both short- and long-term in vivo studies [ 16 , 17 ]. However, despite its immense potential for use in biodegradable orthopedic implants, the very low degradation rate of Fe in physiological media is the main obstacle to its successful clinical application [ 1 , 2 , 18 ]. Because long-lasting biodegradable materials in the body act like permanent materials, Fe implants inevitably provoke chronic foreign body reactions, causing implant loosening and eventual failure [ 1 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Accelerated biodegradation of iron-based implants via tantalum-implanted surface nanostructures

Lee

Park

et al. 2022

Bioactive Materials

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In recent years, pure iron (Fe) has attracted significant attention as a promising biodegradable orthopedic implant material due to its excellent mechanical and biological properties. However, in physiological conditions, Fe has an extremely slow degradation rate with localized and irregular degradation, which is problematic for practical applications. In this study, we developed a novel combination of a nanostructured surface topography and galvanic reaction to achieve uniform and accelerated degradation of an Fe implant. The target-ion induced plasma sputtering (TIPS) technique was applied on the Fe implant to introduce biologically compatible and electrochemically noble tantalum (Ta) onto its surface and develop surface nano-galvanic couples. Electrochemical tests revealed that the uniformly distributed nano-galvanic corrosion cells of the TIPS-treated sample (nano Ta–Fe) led to relatively uniform and accelerated surface degradation compared to that of bare Fe. Furthermore, the mechanical properties of nano Ta–Fe remained almost constant during a long-term in vitro immersion test (~40 weeks). Biocompatibility was also assessed on surfaces of bare Fe and nano Ta–Fe using in vitro osteoblast responses through direct and indirect contact assays and an in vivo rabbit femur medullary cavity implantation model. The results revealed that nano Ta–Fe not only enhanced cell adhesion and spreading on its surface, but also exhibited no signs of cellular or tissue toxicity. These results demonstrate the immense potential of Ta-implanted surface nanostructures as an effective solution for the practical application of Fe-based orthopedic implants, ensuring long-term biosafety and clinical efficacy.

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“…The corrosion current density ( I corr ) of samples was calculated by tafel extrapolation of the anodic and cathodic part of the polarization curves. Afterward, the I corr was converted into the electrochemical corrosion rates based on the ASTM G59 standard[ 36 , 37 ]. The surface morphologies of the samples were examined using a Wyko NT9100 optical profiler (VEECO, USA) and the surface roughness value ( Ra ) was simultaneously acquired by the average standard deviation of height values.…”

Section: Methodsmentioning

confidence: 99%

Hydrolytic Expansion Induces Corrosion Propagation for Increased Fe Biodegradation

Shuai

Peng

et al. 2020

IJB

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Fe is regarded as a promising bone implant material due to inherent degradability and high mechanical strength, but its degradation rate is too slow to match the healing rate of bone. In this work, hydrolytic expansion was cleverly exploited to accelerate Fe degradation. Concretely, hydrolyzable Mg2Si was incorporated into Fe matrix through selective laser melting and readily hydrolyzed in a physiological environment, thereby exposing more surface area of Fe matrix to the solution. Moreover, the gaseous hydrolytic products of Mg2Si acted as an expanding agent and cracked the dense degradation product layers of Fe matrix, which offered rapid access for solution invasion and corrosion propagation toward the interior of Fe matrix. This resulted in the breakdown of protective degradation product layers and even the direct peeling off of Fe matrix. Consequently, the degradation rate for Fe/Mg2Si composites (0.33 mm/y) was significantly improved in comparison with that of Fe (0.12 mm/y). Meanwhile, Fe/Mg2Si composites were found to enable the growth and proliferation of MG-63 cells, showing good cytocompatibility. This study indicated that hydrolytic expansion may be an effective strategy to accelerate the degradation of Fe-based implants.

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Improvement of in vitro corrosion and cytocompatibility of biodegradable Fe surface modified by Zn ion implantation

Cited by 27 publications

References 32 publications

Biodegradable Iron-Based Materials—What Was Done and What More Can Be Done?

Biodegradable Iron-Based Materials—What Was Done and What More Can Be Done?

Accelerated biodegradation of iron-based implants via tantalum-implanted surface nanostructures

Hydrolytic Expansion Induces Corrosion Propagation for Increased Fe Biodegradation

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