Improvement of health-related quality of life and work productivity in chronic hepatitis C patients with early and advanced fibrosis treated with ledipasvir and sofosbuvir

Younossi, Zobair M.; Stepanova, Maria; Afdhal, Nezam H.; Kowdley, Kris V.; Zeuzem, Stefan; Henry, Linda; Hunt, Sharon; Marcellin, Patrick

doi:10.1016/j.jhep.2015.03.014

Cited by 156 publications

(167 citation statements)

References 38 publications

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“…Viral eradication in patients with chronic HCV infection has been shown to result in improvements in medium and long term outcomes -assessed both by patient reported quality of life measurements and mortality/morbidity [10][11][12]. However in patients with advanced, decompensated cirrhosis it is uncertain whether treatment and viral clearance is beneficial, and if meaningful functional hepatic recovery is possible.…”

Section: Introductionmentioning

confidence: 99%

Impact of direct acting antiviral therapy in patients with chronic hepatitis C and decompensated cirrhosis

Foster

Irving

Cheung

et al. 2016

Journal of Hepatology

452

441

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Section: Introductionmentioning

confidence: 99%

Impact of direct acting antiviral therapy in patients with chronic hepatitis C and decompensated cirrhosis

Foster

Irving

Cheung

et al. 2016

Journal of Hepatology

452

441

View full text Add to dashboard Cite

show abstract

“…Also Younossi , et al ( 2015) stated current therapies are not yet good enough to eradicate the hepatitis C virus in all treated patients, factors regarding the impact of therapy on quality of life must be entertained and discussed with the patient, prior to embarking on a course of treatment. Antiviral therapies are associated with a decline in quality of life, which returns to baseline when therapy is terminated.…”

Section: Discussionmentioning

confidence: 99%

Effect of Nursing Intervention Program on Interferone side Effects among Hepatitis C Patients

2017

IJND

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Abstract:Interferone treatment for chronic hepatitis C produces a number of well-described side effects that are dominated by fatigue, influenzalike symptoms, hematologic abnormalities, and neuropsychiatric symptoms. The study aims to assess effect of nursing intervention program on interferone side effects among hepatitis C patients. Material and method: A convenience sample of 100 hepatitis C patients of both sexes in liver institute -Menoufia University was selected for data collection. Tools for data collection included Tool 1: Structured interview questionnaire. It includes 3 parts to assess medical data, lab investigation, and side effect. Tool 2 : patient knowledge questionnaire . Tool 3: Health Related Quality of Life (HRQOL). Results: All studied sample had several complains related to Interferon before giving the nursing management. Also there were statistical significance differences in all laboratory findings. There were statistical significant improvement of the knowledge and quality of life after 3 and 12 months from beginning of the study. Also, there was significant reduction in side effect of interferone therapy after 12 months from beginning of the study. Conclusion: nursing intervention and knowledge about chronic hepatitis C, its treatment and management of Interferon related side effects seemed to have positive effects on improving patient's knowledge about diseases and managing side effects of treatment and self-care modalities that reflected by improvement in laboratory findings, patients complain quality of life. Recommendation: Promotion & enhancement of the self-care modalities to the patient; a strict written instruction with pictures about disease process, prohibited and allowed foods, rest and physical activities and follow up should be continued after termination of the treatment through a rehabilitation program.

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“…Also, subjects who received the interferon-free regimen experienced substantially less fatigue compared with the subjects HCV and Work Ability Assessment http://dx.doi.org/10.5772/intechopen.70774receiving interferon-containing regimens [22]. Another study by Younossi et al showed that interferon and ribavirin-free regimen are associated with signiicant gains in most aspects of HRQL during treatment regardless of the stage of liver disease [24]. Expanding the access to a highly efective cure for all HCV-infected patients will improve the clinical outcomes but also patient-reported outcomes such as HRQL and work productivity, resulting in a superb comprehensive beneit to patients and society.…”

Section: The Impact Of the Hcv Antiviral Therapy On Work Abilitymentioning

confidence: 99%

HCV and Work Ability Assessment

Milošević¹,

Jakab²,

Kuna³

et al. 2017

Update on Hepatitis C

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Improvement of health-related quality of life and work productivity in chronic hepatitis C patients with early and advanced fibrosis treated with ledipasvir and sofosbuvir

Cited by 156 publications

References 38 publications

Impact of direct acting antiviral therapy in patients with chronic hepatitis C and decompensated cirrhosis

Impact of direct acting antiviral therapy in patients with chronic hepatitis C and decompensated cirrhosis

Effect of Nursing Intervention Program on Interferone side Effects among Hepatitis C Patients

HCV and Work Ability Assessment

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