Improvement of erythema dyschromicum perstans using a combination of the 1,550‐nm erbium‐doped fractionated laser and topical tacrolimus ointment

Wolfshohl, Jon; Geddes, Elizabeth R.; Stout, Ashlyn B.; Friedman, Paul M.

doi:10.1002/lsm.22567

Cited by 15 publications

(9 citation statements)

References 17 publications

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“…No clinical improvement of hyperpigmentation was observed, but PIH occurred and patients considered FLT unsatisfactory. The only case of EDP that was successfully treated using laser was in 2017, as reported by Wolsfshohl et al In this study, a patient was successfully treated with a combination of monthly treatments of 1550-nm erbium-doped, fractionated laser and topical tacrolimus over a period of 5 months. The success of the treatment was hypothesized to be secondary to the laser settings and the additive effect of tacrolimus.…”

Section: Resultsmentioning

confidence: 74%

Erythema dyschromicum perstans: A case report and systematic review of histologic presentation and treatment

Leung

Oliveira

et al. 2018

International Journal of Women's Dermatology

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ObjectiveErythema dyschromicum perstans (EDP) can be difficult to diagnose and treat; therefore, we reviewed the literature to assess whether histology can be used to differentiate lichen planus pigmentosus (LPP) from EDP and determine which treatments are the most effective for EDP. We also present a case of a patient who was treated successfully with narrow-band ultraviolet B (NB-UVB).MethodsA systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses was conducted up to July 2017 using four databases.ResultsHistologic analyses from the literature reveal a significant percentage of melanophages, lymphocytic infiltrates, and basal vacuolar degeneration in EDP, and a significant histologic overlap with LPP. The review of the literature on treatment outcomes showed that NB-UVB and tacrolimus were effective with minimal side effects. Clofazimine was effective, but demonstrated significant-to-intolerable side effects. Griseofulvin, isotretinoin, and dapsone provided unsatisfactory results as lesions recurred after discontinuation. Lasers were largely ineffective and may cause postinflammatory hyperpigmentation and fibrosis.ConclusionA diagnosis of EDP should not be based on histologic findings alone. Clinical history, morphology, and distribution should be used to differentiate EDP and LPP. NB-UVB and tacrolimus are promising treatments for EDP with minimal side effects. This is the first report to our knowledge of sustained resolution of EDP after treatment with NB-UVB at long-term follow-up of 4 years. Larger studies are needed to confirm these findings.

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Section: Resultsmentioning

confidence: 74%

Erythema dyschromicum perstans: A case report and systematic review of histologic presentation and treatment

Leung

Oliveira

et al. 2018

International Journal of Women's Dermatology

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“…The disorder is rare in prepubertal children, especially in the Asian population [ 13 ]. In adults, the disorder is more prevalent in the Latin American and Asian population [ 1 , 7 , 9 ]. Dark-skinned individuals (Fitzpatrick types IV and V) are most commonly affected [ 1 , 8 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…In adults, the disorder is more prevalent in the Latin American and Asian population [ 1 , 7 , 9 ]. Dark-skinned individuals (Fitzpatrick types IV and V) are most commonly affected [ 1 , 8 , 9 ]. In contrast to the adult population, children with this disorder are usually Caucasians [ 6 , 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Erythema dyschromicum perstans can be cosmetically distressing and socially embarrassing, especially if the lesion occurs in a visible area such as the face [ 1 , 21 ]. The cutaneous eruption tends to resolve in 2 to 3 years in prepubertal children but tends to persist in adults [ 4 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Erythema dyschromicum perstans, also known as ashy dermatosis or dermatosis cenicienta, is an acquired, chronic pigmentary disorder characterized by slowly progressive, ashy gray-colored macules/patches distributed symmetrically on the trunk and proximal extremities [ 1 ]. The condition was first described in 1957 by Oswaldo Ramirez in Salvadorans [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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