Improvement of early postburn cardiac function by use of Panax notoginseng and immediate total eschar excision in one operation

Huang, Yuesheng; Yang, Zongcheng; Yan, Bai-gang; Hu, Xiaohong; Li, A.N; Crowther, Roger S.

doi:10.1016/s0305-4179(98)00129-6

Cited by 39 publications

(23 citation statements)

References 3 publications

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“…Different lines of evidence suggest that saponin (Gan and Zhen, 1992;Chen et al, 2001), flavonoid (Wei et al, 1980) and polysaccharide (Yang and Du, 2002) are the main active constituents in the roots of P. notoginseng. Saponins of Radix Notoginseng have been reported to increase the blood flow of the coronary arteries (Huang et al, 1999), to prevent platelet aggregation (Wang et al, 2004) and to decrease the consumption of oxygen by heart muscles (Chen et al, 1983). Currently, over 20 different types of saponins have been identified in P. notoginseng root (Gan and Zhen, 1992;Li and Fitzloff, 2001) including ginsenosides, notoginsenosides and gypenosides.…”

Section: Introductionmentioning

confidence: 99%

Orthogonal array design in optimizing the extraction efficiency of active constituents from roots of Panax notoginseng

Dong

Zhao

Huang

et al. 2005

Phytotherapy Research

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The root of Panax notoginseng (Radix Notoginseng, Sanqi) is a commonly used traditional Chinese medicine, which is mainly cultivated in Wenshan of Yunnan China. The identified active constituents in Radix Notoginseng include saponin, ssavonoid and polysaccharide; however, the levels of these active constituents vary greatly with different extraction processes. This variation causes a serious problem in standardizing the herbal extract. By using HPLC and spectrophotometry, the contents of notoginsenoside R(1), ginsenoside R(g1), R(b1), R(d), and ssavonoids were determined in the extracts of Radix Notoginseng that were derived from different processes of extraction according to an orthogonal array experimental design having three variable parameters: nature of extraction solvent, extraction volume and extraction time. The nature of extraction solvent and extraction volume were two distinct factors in obtaining those active constituents, while the time of extraction was a subordinate factor. The optimized condition of extraction therefore is considered to be 20 volumes of water and extracted for 24 h. In good agreement with the amount of active constituents, the activity of anti-platelet aggregation was found to be the highest in the extract that contained a better yield of the active constituents. The current results provide an optimized extraction method for the quality control of Radix Notoginseng.

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Section: Introductionmentioning

confidence: 99%

Orthogonal array design in optimizing the extraction efficiency of active constituents from roots of Panax notoginseng

Dong

Zhao

Huang

et al. 2005

Phytotherapy Research

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“…" PNS have been demonstrated to have extensive effects on the cardiovascular system, including, among others, inhibition of platelet aggregation, increasing blood flow through the coronary arteries, improving left ventricular diastolic function in hypertensive patients, protecting against damage resulting from myocardial ischemia, an antiinflammatory effect due to a reduction of intracellular free calcium levels in neutrophils, reducing myocardial oxygen consumption and an antiarrhythmic effect. [15][16][17][18][19] However, there has not been a detailed investigation of PNS in the treatment of AS and the mechanisms involved. 20) The present studies were designed to address the role of PNS in the progression of AS and to explore the possible relevant molecular mechanisms.…”

mentioning

confidence: 99%

Panax notoginseng Saponins Attenuate Atherogenesis Accelerated by Zymosan in Rabbits

Liu

Zhang

Jia

et al. 2010

Biological & Pharmaceutical Bulletin

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Panax notoginseng saponins (PNS) are highly valued traditional Chinese medicine. The effects of PNS (120 mg/kg, once daily administrated intragastrically (i.g.)) on atherosclerosis induced by a high-cholesterol diet and chronic inflammation, which was derived through zymosan (10 mg/kg, once every 2 d) administration intraperitoneally, were evaluated in rabbits for 8 weeks. A normal group, a simple high-fat diet group, and a zymosan plus high-cholesterol diet group (Zym) were used as controls. Typical pathologic changes associated with atherosclerosis in rabbits following induction by zymosan were alleviated by PNS treatment. After 2, 4, 6, and 8 weeks of treatment, PNS decreased the serum levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, interleukin-6 and C-reactive protein as well as increased high-density lipoprotein cholesterol level significantly in comparison with those in the Zym group, except for triglycerides at week 2. In addition, PNS treatment significantly decreased the mRNA expression levels of monocyte chemoattactant protein-1 and nuclear factor-kB/p65 in the aorta wall after 8 weeks of treatment compared with the Zym group. In conclusion, PNS attenuates atherogenesis through an antiinflammatory action and regulation of the blood lipid profile.

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“…Panax notoginseng saponins (PNS), the principal ingredients extracted from Panax notoginseng, have extensive effects on the cardiovascular system, including, among others, inhibition of platelet aggregation, invigorating blood flow in the coronary arteries (22,23), improving left ventricular diastolic function in hypertensive patients (23), protecting against damage resulting from myocardial ischemia (24), reducing myocardial oxygen consumption and anti-arrhythmic action (25). However, the effect of the Panax notoginseng flower extract (PNFE) on heart diseases, such as ventricular hypertrophy, has yet to be evaluated.…”

Section: Effects Ofmentioning

confidence: 99%

Effects of Panax notoginseng flower extract on the TGF-β/Smad signal transduction pathway in heart remodeling of human chymase transgenic mice

et al. 2012

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Abstract. Panax notoginseng is a common Chinese herb extensively used in Chinese medical practice for the treatment of cardiovascular diseases. The present study aimed to evaluate the effects of Panax notoginseng flower extract (PNFE) on the TGF-β/Smad signal transduction pathway in heart remodeling of human chymase transgenic mice. After treatment with PNFE and soybean trypsin inhibitor (SBTI), the left ventricular mass indexes (LVMIs) of transgenic and normal C57 BL/6 mice were analyzed. The mRNA expression of chymase, TGF-β1, Smad2, Smad3 and Smad7 in myocardium was assessed with RT-PCR, while the protein expression in myocardium was detected by western blotting. The results showed that PNFE and SBTI treatment led to a significant reduction in LVMIs in transgenic mice, indicating a beneficial effect on left ventricular remodeling. Mechanistically, PNFE and SBTI treatment attenuated the mRNA expression of chymase, TGF-β1, Smad2 and Smad3, as well as the protein expression in the myocardium tissues of the transgenic mouse model. By contrast, PNFE and SBTI treatment markedly up-regulated the mRNA and protein expression of Smad7. It was concluded that PNFE was able to improve the ventricular hypertrophy state in human chymase transgenic mice through regulation of the expression of mRNA and protein of TGF-β/ Smad in ventricular tissues.

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Improvement of early postburn cardiac function by use of Panax notoginseng and immediate total eschar excision in one operation

Cited by 39 publications

References 3 publications

Orthogonal array design in optimizing the extraction efficiency of active constituents from roots of Panax notoginseng

Orthogonal array design in optimizing the extraction efficiency of active constituents from roots of Panax notoginseng

Panax notoginseng Saponins Attenuate Atherogenesis Accelerated by Zymosan in Rabbits

Effects of Panax notoginseng flower extract on the TGF-β/Smad signal transduction pathway in heart remodeling of human chymase transgenic mice

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