Improvement of Diabetes Mellitus After Colorectal Cancer Surgery: A Retrospective Study of Predictive Factors For Type 2 Diabetes Mellitus Remission and Overall Survival

Abstract

PurposeThe purpose of the current study was to evaluate the impact of colorectal cancer (CRC) surgery on type 2 diabetes mellitus (T2DM) and to analyze the change in T2DM on overall survival after CRC surgery.MethodsPatients who underwent CRC surgery were retrospectively enrolled from January 2013 to December 2019. The status of T2DM pre- and 1-year after CRC surgery was recorded, and predictive factors for T2DM remission and overall survival were analyzed.ResultsA total of 296 patients were included in this study. Thirty-eight patients experienced remission of T2DM 1 year after CRC surgery, and the remission rate was 12.8%. Weight loss was significantly higher in the T2DM remission group (p = 0.038), and the T2DM duration was significantly shorter in the T2DM remission group (p = 0.015). In the multivariate logistic regression analysis, higher weight loss (p = 0.046, odds ratio = 1.060, 95% CI = 1.001–1.122) and shorter T2DM duration (p = 0.019, odds ratio = 1007, 95% CI = 1.001–1.014) were predictive factors for remission of T2DM. Furthermore, in multivariate Cox regression analysis, lower TNM stage (p = 0.000, odds ratio = 2.147, 95% CI = 1.474–3.128) and T2DM remission (p = 0.033, odds ratio = 2.999, 95% CI = 1.091–8.243) were the predictive factors for better overall survival.ConclusionPatients with concurrent CRC and T2DM had a 12.8% remission 1 year after CRC surgery. Higher weight loss and shorter T2DM duration contributed to T2DM remission, and patients with T2DM remission could improve in terms of their overall survival.

The Effect of Type 2 Diabetes Mellitus on the Short-Term Outcomes and Prognosis of Stage I–III Colorectal Cancer: A Propensity Score Matching Analysis

“…There were many factors that affected the prognosis of CRC, including age, tumor stage, and complications. [30][31][32] In this study, we had the similar findings consistent with previous studies. In this study, T2DM was not a predictive factor in multivariate analysis.…”

The short-term and oncologic outcomes of younger VS older colorectal cancer patients undergoing primary surgery: a propensity score matching analysis

“…There were many factors that could affect the prognosis of CRC patients including tumor stage, BMI, T2DM, age and complications [ 3 , 21 – 24 ]. In this study, tumor stage and complications were independent predictors of CRC patients which was similar with previous studies [ 3 , 21 , 22 ].…”

“…There were many factors that could affect the prognosis of CRC patients including tumor stage, BMI, T2DM, age and complications [ 3 , 21 – 24 ]. In this study, tumor stage and complications were independent predictors of CRC patients which was similar with previous studies [ 3 , 21 , 22 ]. In addition, younger aged patients were associated with better prognosis than older aged patients, which meant that after radical CRC surgery, age was an important factor affecting the prognosis.…”

“…Colorectal cancer (CRC) is one of the most common cancers with approximate 185 million cases worldwide [ 1 ], in addition, CRC is one of the most common causes of cancer-related deaths, with nearly 700,000 deaths every year [ 2 ]. Radical surgery is the cornerstone of CRC treatment [ 3 – 5 ].…”

Impact of Preoperative Type 2 Diabetes Mellitus on the Outcomes of Gastric Cancer Patients Following Gastrectomy: A Propensity Score Matching Analysis

“…In addition, T2DM was not the predictive factor for OS (p = 0.595 > 0.05, HR = 0.876, 95% CI = 0.538-1.426) or DFS (p = 0.211>0.05, HR = 1.509, 95% CI = 0.792-2.874) (Tables 5, 6). T2DM is a metabolic disease, which is related to the onset of digestive tumors including gastric cancer, colorectal cancer, and esophageal cancer (9,19,20). In addition to the influence on tumor onset, T2DM might also affect the prognosis of patients, including OS, DFS, and cancer-specific survival (12,14).…”