Improvement of Depth Profiling into Biotissues Using Micro Electrical Impedance Spectroscopy on a Needle with Selective Passivation

Yun, Joungil; Kim, Hyeon Woo; Lee, Jong‐Hyun

doi:10.3390/s16122207

Cited by 16 publications

(20 citation statements)

References 39 publications

(40 reference statements)

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“…Previous work with bipolar systems report impedance changes as a function of probe insertion depth (Bolger et al 2006, Yun et al 2016. To minimize this depth dependence, a 15 μm thick diamond-like carbon (DLC) coating (IBC Coatings Technologies, Lebanon, IN) was applied to the surface of a standard 2 mm cannulated twist drill (Type 36117, Nobel Biocare, Kloten, Switzerland) everywhere except the distal 2 mm and within the cannula via a Plasma Assisted Chemical Vapor Deposition (PACVD) process.…”

Section: Device Developmentmentioning

confidence: 99%

Gauging electrical properties of bone with a bioimpedance-sensing drill

Butler

Halter

2019

Physiol. Meas.

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Objective: Multiple surgical procedures require drilling through bone to access underlying anatomy or for device placement. In dental applications, iatrogenic injury caused by accidental perforation of cortical bone into critical anatomy occurs in a significant number of dental implant procedures. Limited real-time sensing methods are available to guide clinicians while drilling through cancellous bone towards cortical interfaces. Early interface detection could prevent accidental damage to underlying anatomic structures. This study aims to demonstrate that electrical impedance spectroscopy can be integrated within a standard surgical drill to distinguish between bone types. Approach: A custom bearing and insulated drill bit were designed to collect 10 cortical and cancellous impedance measurements from ex vivo femurs (2 pigs) and 80 bone measurements from in situ femurs (4 pigs). In the in situ study, two return electrodes (simulating a lip-clip and shoulder pad) were used to assess impedance differences associated with return electrode geometry. Main results: Significant ex vivo differences (p < 0.05) between cortical and cancellous bone occurred in the real resistivity from 0.1 to 100 kHz and in the imaginary resistivity from 0.3 to 10 kHz, with a maximum cortical-to-cancellous impedance ratio of 1.48. Significant in situ differences (p < 0.01) were observed in both real and imaginary resistivities from 0.1 to 100 kHz, with a maximum impedance ratio of 2.94. AUCs for classifying bone type based on the real resistivity ranged from 0.84 to 0.96 for ex vivo bone and 0.98 to 1.0 for in situ bone. Mean differences between return electrode geometries were less than 5%. Significance: The significant cortical-to-cancellous contrast observed indicates this system's potential to provide real-time tissue differentiation during bone drilling procedures.

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Section: Device Developmentmentioning

confidence: 99%

Gauging electrical properties of bone with a bioimpedance-sensing drill

Butler

Halter

2019

Physiol. Meas.

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“…Depending on the technique, the needles must either be directed to their target position or kept on a straight path to improve the targeting precision and hence quality of care. measurements [25,26]. An impedance measurement analyzer with an injectable monopolar needle electrode has been used in various clinical fields for tissue biopsy, peripheral intravenous catheterization and lumbar puncture.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, many studies have determined the electrical impedance of organic cells using electrochemical impedance spectroscopy [30,31]. The EIS-on-a-needle (EoN) technique can calculate the electrical impedance dependent on an electrochemical system, for example, the electrical properties of the sample, and the constant phase element (CPE) on the surface near to the electrodes [26,32]. EoN consists of two main components, a connection part and a detection part.…”

Section: Introductionmentioning

confidence: 99%

“…The study reported that the target tissues are located deep inside, and the connection part tends to be in contact with the biological tissues that cause errors at the output. In addition, distortion in the sensor performance can be alleviated by using an insulation layer (SU-8 photoresist) for the contact partition [26]. Kim et al, were the first to introduce an incremental compensation algorithm to boost the detection accuracy [34], and demonstrated the feasibility of the proposed algorithm in distinguishing between normal and cancer tissues ex-vivo [35].…”

Section: Introductionmentioning

confidence: 99%

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Real-Time Impedance Detection of Intra-Articular Space in a Porcine Model Using a Monopolar Injection Needle

Abbasi

Kim

Chinnadayyala

et al. 2020

Sensors

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Rheumatoid arthritis and osteoarthritis can be treated through specific drug injection into the intra-articular space. Several failures during drug injection attempts with conventional fluoroscopy and ultrasonography in a small area of the intra-articular space have been reported. In this work we present an innovative impedance measurement-based method/algorithm for needle tip positioning to enhance image-guided intra-articular vaccination treatment. A novel algorithm for detecting the intra-articular space in the elbow and knee joints of a live porcine model is reported. An impedance measurement system was developed for biological tissue measurement. The electrical impedance in the intra-articular space was monitored and the needle tip was examined by ultrasonography. The contrast dye was vaccinated and checked using fluoroscopy to confirm that the dye was properly inoculated in the cavity. The electrical impedance was estimated for various needle inclusion profundity levels in saline solution, which were broadly used to evaluate the proposed device for in vivo examinations. Good efficiency was observed in the impedance-based measurements using a monopolar injection needle for intra-articular therapy. To enhance the needle tip positioning for intra-articular therapy, the intended impedance measurement device with a monopolar injection needle can be used as a complement to existing modalities.

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“…To accurately detect the needle position in vivo, electrical impedance characterization of tissues can be applied, which non-destructively measures in real-time the electrical properties of the tissue by using a weak alternating electric field [4,5]. Kalvøy et al reported the feasibility of the needle guidance in clinical applications using the finite element method (FEM) simulation of electric fields to the electrical impedance (EI) measurement on tissues [6].…”

Section: Introductionmentioning

confidence: 99%

Electrical Characterization of Pork Tissue Measured by a Monopolar Injection Needle and Discrete Fourier Transform based Impedance Measurement

Abbasi

Kim

et al. 2019

Applied Sciences

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Ultrasonography or fluoroscopy-guided needle injection has been used for intra-articular injection therapy against adhesive capsulitis and joint diseases. To improve the image-guided intra-articular injection therapy, electrical impedance measurement based positioning of the needle tip in the target tissue can be applied. The feasibility of the discrimination for the tissue layer at which the disposable monopolar injection needle tip position was investigated using the discrete Fourier transform (DFT)-based impedance measurement system and the ultrasound imaging device. The electrical impedance spectra of the pork tissue measured in the frequency range of 200 Hz to 50 kHz were characterized by designed equivalent circuit modeling analysis. The normalized impedance data of the tissue layers (dermis, hypodermis, and muscle) were significantly different from each other (p-value < 0.001). The DFT-based impedance measurement system with a monopolar injection needle can be complementary to the image-guided intra-articular injection therapy.

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Improvement of Depth Profiling into Biotissues Using Micro Electrical Impedance Spectroscopy on a Needle with Selective Passivation

Cited by 16 publications

References 39 publications

Gauging electrical properties of bone with a bioimpedance-sensing drill

Gauging electrical properties of bone with a bioimpedance-sensing drill

Real-Time Impedance Detection of Intra-Articular Space in a Porcine Model Using a Monopolar Injection Needle

Electrical Characterization of Pork Tissue Measured by a Monopolar Injection Needle and Discrete Fourier Transform based Impedance Measurement

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