Improvement of chitosan solubility and bactericidity by synthesis of N-benzimidazole-O-acetyl-chitosan and its electrodeposition

Enhanced Immune Responses to Mucosa by Functionalized Chitosan-Based Composite Nanoparticles as a Vaccine Adjuvant for Intranasal Delivery

“…Unfortunately, the poor solubility and the restricted drug-loading efficiency of native chitosan limit its applications in biomedical research. By modifying the structure of chitosan with hydrophilic groups, the solubility and the physicochemical properties of chitosan are greatly improved. − Nanoparticles prepared based on these chitosan derivatives further enhance the adsorption of antigen vaccines at the mucosal site and promote the uptake efficiency of vaccines by cells, broadening the usage of chitosan in the field of vaccine research. , Current studies mainly focus on the effective preparation of nano-carriers and the optimization of parametric properties, while the immunomodulatory function of nano-carriers themselves is still in the early research stage.…”

Thermal-Responsive and 3D Printable Hydrogel Based on an Acylhydrazine-Terminated Dynamic Covalent Bond and Pluronic F127

“…This temperature-responsive and good biocompatibility characteristic have led to Pluronic F127’s wide range of applications in biology. − Our design strategies for preparing high-strength and printable hydrogel were that hydrogel could form hydrophobic/hydrophilic zones. So, we chose PEG as the hydrophilic constructional element rather than other biomaterials, such as polysaccharides, and proteins, owing to its good biocompatibility, water solubility, and pH insensitivity. − Otherwise, to increase the product’s durability, hydrogel should have characteristics like self-healing abilities. , Herein, the acylhydrazone bond was introduced into the hydrogel’s design, which was formed by the reaction of the acylhydrazine and benzaldehyde terminals. − …”

Development and Characterization of Lysozyme Pellets Prepared by Extrusion and Spheronization Method

“…biocompatibility, biodegradability, non-toxicity and low immunogenicity, makes chitosan the second most abundant natural polymer in the world (Cao et al, 2018. Chitosan is a weak base, which is soluble in an aqueous acidic media and produces highly viscous solutions suitable for the preparation of free films and coatings (Rahmouni et al, 2018). Chitosan exhibits excellent mucoadhesive properties due to presence of reactive hydroxyl and amino groups providing excessive hydrogen bonding as well as a positive charge, resulting in a unique linear polycation with a high charge density (Agarwal et al, 2018).…”

“…Its unique properties such as biocompatibility, biodegradability, non-toxicity and low immunogenicity make chitosan the second most abundant natural polymer in the world [130,131], and due to its weak alkaline nature, chitosan is solubilized by aqueous acidic media and produces highly viscous solutions suitable for the preparation of free films and coatings [132].…”

“…From the pharmaceutical aspect, both polymeric micro-and nanoparticles are of emerging interest since they show better stability and therefore better preservation capacity against the degrading effect of the GI environment compared to the carriers of fatty origin, such as liposomes [132]. The effectiveness of protein drugs may be improved successfully with both micro-and nanoencapsulation [133] via protection from hydrolysis and proteolytic enzymes and the improvement of their absorption, in addition to their mucoadhesive properties and permeation enhancing characteristics [134].…”