Improvement of aqueous stability and anti-osteoporosis properties of Zn-MOF coatings on titanium implants by hydrophobic raloxifene

Shen, Xinkun; Yie, Kendrick Hii Ru; Wu, Xinghai; Zhou, Zixin; Sun, Anba; Al-Bishari, Abdullrahman M.; Fang, Kai; Baadani, Mohammed A. Al; Deng, Zhennan; Ma, Pingping; Liu, Jinsong

doi:10.1016/j.cej.2021.133094

Cited by 31 publications

(14 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[32] This means that the introduction of methyl groups can greatly improve the stability of the framework of Zn-bzc-2CH 3 and well meet the precondition for industrial application. It is well known that most reported Zn-based MOFs are unstable in water, even in the atmosphere, [33,34] due to the weak coordination bond between Zn and carboxylic acid. Herein, the excellent water stability of Znbzc-2CH 3 MOF can be attributed to the shielding effect of abundant hydrophobic methyl groups on the coordination bond of MOF, which can efficiently repel the attack of water molecules.…”

Section: Methodsmentioning

confidence: 99%

Stepwise Engineering the Pore Aperture of a Cage‐like MOF for the Efficient Separation of Isomeric C4 Paraffins under Humid Conditions

et al. 2023

View full text Add to dashboard Cite

The separation of isomeric C4 paraffins is an important task in the petrochemical industry, while current adsorbents undergo a trade‐off relationship between selectivity and adsorption capacity. In this work, the pore aperture of a cage‐like Zn‐bzc (bzc=pyrazole‐4‐carboxylic acid) is tuned by the stepwise installation methyl groups on its narrow aperture to achieve both molecular‐sieving separation and high n‐C4H10 uptake. Notably, the resulting Zn‐bzc‐2CH3 (bzc‐2CH3=3,5‐dimethylpyrazole‐4‐carboxylic acid) can sensitively capture n‐C4H10 and exclude iso‐C4H10, affording molecular‐sieving for n‐C4H10/iso‐C4H10 separation and high n‐C4H10 adsorption capacity (54.3 cm3 g−1). Breakthrough tests prove n‐C4H10/iso‐C4H10 can be efficiently separated and high‐purity iso‐C4H10 (99.99 %) can be collected. Importantly, the hydrophobic microenvironment created by the introduced methyl groups greatly improves the stability of Zn‐bzc and significantly eliminates the negative effect of water vapor on gas separation under humid conditions, indicating Zn‐bzc‐2CH3 is a new benchmark adsorbent for n‐C4H10/iso‐C4H10 separation.

show abstract

Section: Methodsmentioning

confidence: 99%

Stepwise Engineering the Pore Aperture of a Cage‐like MOF for the Efficient Separation of Isomeric C4 Paraffins under Humid Conditions

et al. 2023

View full text Add to dashboard Cite

show abstract

“…After sequential machining with sandpapers (600–3000 meshes) and ultrasonic cleaning by ethanol and DI water, pure Ti was treated with 5 M sodium hydroxide for 1 d at 80 °C, and the resultant samples were named as AHT …”

Section: Experimental Methodsmentioning

confidence: 99%

Nanocatalytic Biofunctional MOF Coating on Titanium Implants Promotes Osteoporotic Bone Regeneration through Cooperative Pro-osteoblastogenesis MSC Reprogramming

Chen

Wang

et al. 2022

ACS Nano

View full text Add to dashboard Cite

An elevated bone microenvironmental reactive oxygen species (ROS) level is a hallmark of osteoporosis that often leads to the dysfunction of bone-related mesenchymal stem cells (MSCs), which would induce MSC senescence and severely undermine their osteoblastic potential. Herein, we report the in situ construction of bone microenvironment-responsive biofunctional metal–organic framework (bio-MOF) coating on the titanium surface through the coordination between p-xylylenebisphosphonate (PXBP) and Ce/Sr ions by a hydrothermal method. Taking advantage of the anchored Ce and Sr ions, the AHT-Ce/SrMOF implants demonstrate on-demand superoxide dismutase and catalase-like catalytic activities to decompose ROS in MSCs and restore their mitochondrial functions. In vitro analysis showed that the AHT-Ce/SrMOF implants substantially activated the AMP-activated protein kinase (AMPK) signaling pathway in MSCs and reduced the ROS levels. Meanwhile, MSCs grown on AHT-Ce/SrMOF implants displayed significantly higher expressions of the mitochondrial fission marker (DRP1), mitochondrial fusion marker (MFN2 and OPA1), and mitophagy marker (PINK1 and LC3) than those of the AHT-CeMOF and AHT-SrMOF groups, which indicated that the bio-MOF could amend mitochondrial function in MSCs to reverse senescence. In vivo evaluations showed that the bio-MOF-coated Ti implants could restore MSC function in the implant site and promote new bone formation, leading to improved osteointegration in osteoporotic rat. This study may improve implant-mediated fracture healing in the clinics.

show abstract

“…150 In addition, a MAO-PLA modified Zn–Mg–Mn alloy exhibited greater corrosion resistance. 151 As for structural changes, a pure Zn membrane with 1000 μm pores possessed faster degradation than that with 300 μm pores. 141 And grain refinement of the Zn–Fe alloy can improve both uniformity and resistance of degradation.…”

Section: Application Of Zinc-based Biomaterials In Bone Repair and Re...mentioning

confidence: 98%

Zinc-based biomaterials for bone repair and regeneration: mechanism and applications

Wen,

Wang,

Pei

et al. 2023

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

Improvement of aqueous stability and anti-osteoporosis properties of Zn-MOF coatings on titanium implants by hydrophobic raloxifene

Cited by 31 publications

References 59 publications

Stepwise Engineering the Pore Aperture of a Cage‐like MOF for the Efficient Separation of Isomeric C4 Paraffins under Humid Conditions

Stepwise Engineering the Pore Aperture of a Cage‐like MOF for the Efficient Separation of Isomeric C4 Paraffins under Humid Conditions

Nanocatalytic Biofunctional MOF Coating on Titanium Implants Promotes Osteoporotic Bone Regeneration through Cooperative Pro-osteoblastogenesis MSC Reprogramming

Zinc-based biomaterials for bone repair and regeneration: mechanism and applications

Contact Info

Product

Resources

About