“…OMS formulation compares well with the marketed product (sporanox) thus considered as better carrier.136 | Porous silicon based microparticles | – | Antipyrene, ibuprofen, griseofulvin, ranitidine, furosemide | II, IV | Drug loaded in mesoporous silicon microparticle increased the dissolution rate and reduced the pH dependency dissolution. | 137 |
Micelle | Thin film hydration | Amphotericin | II | Self-assembled lecithin-based mixed polymeric micelle containing pluronic, kolliphor RH40,TPGS and DSPE-PEG2K showed 2.18- and 1.50-fold increased in bioavailability when administered i.v. and orally. | 138 |
Micelle | Dialysis method | Paclitaxel | IV | Pluronic F127, P188 and heparin-all- trans -retinoid acid conjugate mixed micelle exhibited higher AUC, C max and 5- to 6-fold increase in effective permeability. | 139 |
Co-crystal | – | Quercetin | II | Quercetin–caffeine, quercetin–caffeine–methanol, quercetin–isonicotinamide and quercetin–theobromine dihydrate co-crystals exhibited pharmacokinetic properties that are vastly superior than quercetin alone. | 140 |
Co-crystal | Anti-solvent crystallization | Indomethacin | II | Saccharine-indomethacin cocrystals were hygroscopic and found to have significantly higher dissolution rate than pure indomethacin. | 141 |
Co-crystal | Anti-solvent crystallization | Diflunisal | II | Nicotinamide–diflunisal cocrystal improves intrinsic dissolution rate by 20%. | 142 |
Co-crystal | Anti-solvent crystallization | Ibuprofen | II | Highly soluble molecule in crystallographic pattern of ibuprofen enhances the solubility more than 7.5 times. | 143 |
Co-crystal | Anti-solvent crystallization | Ezetimibe | II | Benzoic acid and salicylic acid ezetimibe co-crystal showed significant enhancement in the dissolution profile as compared to pure ezetimibe. | 144 |
Dendrimer | – | Camptothecin | II | G.4 and G.3.5 PAMAM dendrimer increased camptothecin solubilization in simulated gastric fluid and caused 2-fold to 3-fold increase in oral absorption suggested increased bioavailability. | 145 |
Dendrimer | – | Famotidine, indomethacin, amphotericin | II | G.5 PPI dendrimer–drug complex demonstrated increase in solubility due to hydrophobic and electrostatic interactions for acidic, basic and amphoteric drug. | 146 |
Dendrimer |
…”