Improvement in neurogenesis and memory function by administration of Passiflora incarnata L. extract applied to sleep disorder in rodent models

Kim, Gwang Hoon; Lim, Kyunghyun; Yang, Hae Sung; Lee, Ji-Kwang; Kim, Yehlim; Kim, Sohyeon; Park, Suhyeon; Kim, Tae-Hee; Moon, Jong‐Seok; Hwang, In Koo; Yoon, Yeo Sung; Seo, Hyeonji; Nam, Sung Min; Kim, Mi‐Yeon; Yoon, Seul Gi; Seong, Je Kyung; Yi, Sun Shin

doi:10.1016/j.jchemneu.2019.03.005

Cited by 25 publications

(20 citation statements)

References 49 publications

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“…Hippocampal neurogenesis drives the development of neuroblast in the SGZ hippocampal DG [51,52]. These neuroblasts migrate into GCL during maturation [50,51]. Since dendrites stretching out from neuroblast signal transmission by associating with the surrounding cerebral parenchymal structure, the number of branches of dendrites as well as the number of neuroblasts is considered [51,52].…”

Section: Nox4 Deficiency Exacerbates the Impairment Of Hippocampal Nementioning

confidence: 99%

“…We analyzed hippocampal neurogenesis by measuring a DCX-positive neuroblast, which is a neuronal differentiation marker, in Nox4 −/− and WT mice. Hippocampal neurogenesis drives the development of neuroblast in the SGZ hippocampal DG [51,52]. These neuroblasts migrate into GCL during maturation [50,51].…”

Section: Nox4 Deficiency Exacerbates the Impairment Of Hippocampal Nementioning

confidence: 99%

“…These neuroblasts migrate into GCL during maturation [50,51]. Since dendrites stretching out from neuroblast signal transmission by associating with the surrounding cerebral parenchymal structure, the number of branches of dendrites as well as the number of neuroblasts is considered [51,52]. We measured the number of DCX-positive neuroblasts, which are differentiated neuroblasts, and the degree of dendrite branching in DCX-positive neuroblasts distributed along the SGZ and GCL of hippocampal DG in Nox4 −/− and WT mice ( Figure 3A).…”

Section: Nox4 Deficiency Exacerbates the Impairment Of Hippocampal Nementioning

confidence: 99%

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NOX4 Deficiency Exacerbates the Impairment of Cystatin C-Dependent Hippocampal Neurogenesis by a Chronic High Fat Diet

Jiranugrom

Yoo

Park

et al. 2020

Genes

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Hippocampal neurogenesis is linked with a cognitive process under a normal physiological condition including learning, memory, pattern separation, and cognitive flexibility. Hippocampal neurogenesis is altered by multiple factors such as the systemic metabolic changes. NADPH oxidase 4 (NOX4) has been implicated in the regulation of brain function. While the role of NOX4 plays in the brain, the mechanism by which NOX4 regulates hippocampal neurogenesis under metabolic stress is unclear. In this case, we show that NOX4 deficiency exacerbates the impairment of hippocampal neurogenesis by inhibiting neuronal maturation by a chronic high fat diet (HFD). NOX4 deficiency resulted in less hippocampal neurogenesis by decreasing doublecortin (DCX)-positive neuroblasts, a neuronal differentiation marker, and their branched-dendrites. Notably, NOX4 deficiency exacerbates the impairment of hippocampal neurogenesis by chronic HFD. Moreover, NOX4 deficiency had a significant reduction of Cystatin C levels, which is critical for hippocampal neurogenesis, under chronic HFD as well as normal chow (NC) diet. Furthermore, the reduction of Cystatin C levels was correlated with the impairment of hippocampal neurogenesis in NOX4 deficient and wild-type (WT) mice under chronic HFD. Our results suggest that NOX4 regulates the impairment of Cystatin C-dependent hippocampal neurogenesis under chronic HFD.

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Section: Nox4 Deficiency Exacerbates the Impairment Of Hippocampal Nementioning

confidence: 99%

Section: Nox4 Deficiency Exacerbates the Impairment Of Hippocampal Nementioning

confidence: 99%

Section: Nox4 Deficiency Exacerbates the Impairment Of Hippocampal Nementioning

confidence: 99%

See 1 more Smart Citation

NOX4 Deficiency Exacerbates the Impairment of Cystatin C-Dependent Hippocampal Neurogenesis by a Chronic High Fat Diet

Jiranugrom

Yoo

Park

et al. 2020

Genes

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“…Vitexin was believed as a main product in our established extract method. Many studies have reported that vitexin has the ability to induce sleepiness, is antidiabetic, anti-inflammatory, and effective for sleep improvement [9,14,20]. PI extracts showed increased calretinin at the hippocampus and hypothalamus known as calcium binding protein secreted by GABAergic neurons [12,27,37].…”

Section: Discussionmentioning

confidence: 99%

Chronic oral administration of Passiflora incarnata extract has no abnormal effects on metabolic and behavioral parameters in mice, except to induce sleep

Kim

2019

Lab Anim Res

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Although the number of prescriptions and dependence on sleeping pills are increasing, the associations with unexpected abnormal behaviors and metabolic diseases caused by the overuse of sleeping pills are not well understood. In particular, such as abnormal eating-behavior and the occurrence of metabolic disorders caused by psychological unstable states are reported. For this reason, herbal medicine, which has not had such side effects in recent years, is attracting attention as an alternative medicine/food for sleeping inducer. We have used ethanol extracts from Passiflora incarnata (PI) to steadily obtain positive effects on sleep and brain microenvironment. However, as mentioned earlier, sleep-inducing efficacy can only be used safely if the behavioral and metabolic abnormalities do not appear. Thus, in this study, we used Phenomaster equipment to continuously monitor the movement, feeding, water consumption, gas changes, etc. in C57BL/6 mice at a dose of 500 mg/kg/day for 5 consecutive days with PI extract group compared with the control group. Before sacrifice, differences in body composition of mice were also compared. Monitoring of 24 h/5 days through the equipment showed no change in PI-treated group in anything except for significant decrease in blood melatonin levels and activity after PI administration. Taken together, the statistically insignificance of any behavioral and metabolic phenomenon produced by repeated treatment of PI are not only expected to have an accurate sleep effect, but are also free of side effects of the prescribed sleeping pills. This study has given us greater confidence in the safety of the PI extracts we use for sleep-inducer.

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“…Muitas espécies de passifloras estão associadas à atividade ansiolítica, sedativa, antidepresiva e contra distúrbios do sono (AYRES et al, 2015GAZOLA et al, 2018;KIM et al, 2019). Mais recentemente, foram reportados efeito anti-inflamatório, antidiabético, antimicrobiano neuroprotetores e antioxidantes para espécies nativas indicando o grande potencial biológico apresentado pelas mesmas CORRÊA et al, 2016;SHANMUGAM et al, 2018).…”

Section: Considerações Iniciaisunclassified

Caracterização de compostos bioativos de maracujá (>i<Passiflora tenuifila>/i<) e efeito do seu consumo sobre marcadores bioquímicos, microbiota intestinal em indivíduos eutróficos e obesos

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Improvement in neurogenesis and memory function by administration of Passiflora incarnata L. extract applied to sleep disorder in rodent models

Cited by 25 publications

References 49 publications

NOX4 Deficiency Exacerbates the Impairment of Cystatin C-Dependent Hippocampal Neurogenesis by a Chronic High Fat Diet

NOX4 Deficiency Exacerbates the Impairment of Cystatin C-Dependent Hippocampal Neurogenesis by a Chronic High Fat Diet

Chronic oral administration of Passiflora incarnata extract has no abnormal effects on metabolic and behavioral parameters in mice, except to induce sleep

Caracterização de compostos bioativos de maracujá (>i<Passiflora tenuifila>/i<) e efeito do seu consumo sobre marcadores bioquímicos, microbiota intestinal em indivíduos eutróficos e obesos

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