Improvement in Human Semen Quality After Oral Supplementation of Vitamin C

Akmal, Mohammad; Qadri, J.Q.; Al-Waili, Noori S.; Thangal, Shahiya; Haq, Afrozul; Saloom, Khelod Y.

doi:10.1089/jmf.2006.9.440

Cited by 110 publications

(59 citation statements)

References 14 publications

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“…This was further corroborated by the association of decreased AA followed by an increase in the seminal plasma LPO as observed in a human trial [126,127]. Moreover, it has been reported that AA supplementation leads to a significant reduction in the ROS concentration, sperm membrane LPO and DNA oxidation together with an increased sperm quality.…”

Section: Vitamin Csupporting

confidence: 64%

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Physiological and Pathological Roles of Free Radicals in Male Reproduction

Tvrdá¹,

Massányi²,

Lukáč³

2018

Spermatozoa - Facts and Perspectives

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Oxidative stress (OS) is a condition caused by an imbalance between reactive oxygen species (ROS) overgeneration and decreased antioxidant defense mechanisms in the cell. OS has become a prominent factor in male reproductive dysfunction as ROS cause damage to sperm DNA, lipids and proteins, alterations to critical sperm structures and signaling pathways, leading to a decreased sperm activity and fertilizing capacity. At the same time, small amounts of ROS play vital roles in events leading to sperm maturation and acquisition of functional activity, which is why a proper oxidative balance is of paramount importance for a proper male fertility. Understanding the physiological and pathological roles of ROS in male reproduction has become an essential pillar of modern andrology; however, numerous questions related to the controversial behavior of ROS in male reproductive cells and tissues still remain unanswered. This chapter aims to summarize current evidence available on the relationships between free radicals, antioxidants and male reproduction and to trigger more scientific interest, particularly with respect to the design of efficient strategies to diagnose or treat male sub-or infertility associated with OS.

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Section: Vitamin Csupporting

confidence: 64%

“…Vitamin C supplementation improved sperm count, motility and morphology [159] • 115 men with clinical varicocele and abnormal semen analyses were recruited. After surgery, the subjects received 250 mg vitamin C for 2 months.…”

Section: Bilirubinmentioning

confidence: 99%

Physiological and Pathological Roles of Free Radicals in Male Reproduction

Tvrdá¹,

Massányi²,

Lukáč³

2018

Spermatozoa - Facts and Perspectives

View full text Add to dashboard Cite

show abstract

“…In an observational study of 250 men undergoing ICSI, sperm motility was positively influenced by consumption of fruits and cereals (Braga et al, 2012). Furthermore, several observational and experimental studies have shown that higher antioxidant intake (such as vitamin E, vitamin C and b-carotene) which is found in fruits and vegetables was associated with improved sperm motility (and other semen parameters such as sperm counts and morphology), in both fertile and infertile men (Keskes-Ammar et al, 2003;Eskenazi et al, 2005;Akmal et al, 2006;Mendiola et al, 2010). A recent systematic review of 17 randomized trials of antioxidant supplementation showed that most trials reported an improvement in sperm motility with antioxidants compared with placebo (Ross et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Dietary patterns and semen quality in young men

Gaskins

Colaci

Mendiola

et al. 2011

Fertility and Sterility

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what is known already: Over the past decades there has been evidence of a concomitant decline in sperm and diet quality. Yet whether diet composition influences semen quality remains largely unexplored. participants, setting, methods: Men aged 18-22 years were included in this analysis. Diet was assessed via food frequency questionnaire and dietary patterns were identified by factor analysis. Linear regression was used to analyze the relation between diet patterns and conventional semen quality parameters (sperm concentration, progressive motility and morphology) adjusting for abstinence time, multivitamin use, race, smoking status, BMI, recruitment period, moderate-to-intense exercise and total calorie intake.results: Two dietary patterns were identified by factor analysis. The 'Western' pattern was characterized by high intake of red and processed meat, refined grains, pizza, snacks, high-energy drinks and sweets. The 'Prudent' pattern was characterized by high intake of fish, chicken, fruit, vegetables, legumes and whole grains. The Prudent pattern was positively associated with percent progressively motile sperm in multivariate models (P-trend ¼ 0.04). Men in the highest quartile of the Prudent diet had 11.3% (95% CI 1.3, 21.3) higher % progressively motile sperm compared with men in the lowest quartile. The Prudent pattern was unrelated to sperm concentration and morphology. The Western pattern was not associated with any semen parameter.limitations: This was a cross-sectional and observational study, which limited our ability to determine causality of diet on semen quality parameters.wider implications of the findings: Our findings support the suggestion that a diet rich in fruits, vegetables, chicken, fish and whole grains may be an inexpensive and safe way to improve at least one measure of semen quality.

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“…Other studies have also shown that nutritional therapies such as vitamins, improve penile erections or sperm counts and motility (Sinclair, 2005;Akmal et al, 2006). In addition, trans-resveratrol (trans-3,4,5-trihydroxystilbene) has been reported to provide health benefits including protection against cardiovascular diseases, which act via the enhanced generation of NO, which in turn trigger vascular relaxation (Chen and Pace-Asciak, 1996;Wallerath et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

trans-resveratrol relaxes the corpus cavernosum ex vivo and enhances testosterone levels and sperm quality in vivo

et al. 2008

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We examined the effects of trans-resveratrol on male reproductive functions; ex-vivo penile erection and in-vivo sperm counts and quality. For the ex-vivo study, the relaxation effects of resveratrol on isolated New Zealand white rabbit corpus cavernosum, precontracted by phenylephrine (5x10(-5) M) were measured. The in-vivo study measured reproductive organ weights, blood testosterone levels, testicular histopathology, sperm counts, as well as the epididymal sperm motility and deformity of male ICR mice given an oral dose of resveratrol (50 mg/ kg) for 28 days. Resveratrol elicited a concentration-dependent relaxing effect on corpus cavernosum, leading to a median effective concentration (EC50) of 0.29 mg/mL. Repeated treatment with resveratrol (50 mg/kg) did not cause an increase in body weight, reproductive organ weight or testicular microscopic findings; however, resveratrol did elicit an increase in blood testosterone concentration, testicular sperm counts and epididymal sperm motility by 51.6%, 15.8% and 23.3%, respectively, without influence on sperm deformity. In conclusion, we propose that resveratrol has a positive effect on male reproductive function by triggering a penile erection, as well as enhancing blood testosterone levels, testicular sperm counts, and epididymal sperm motility.

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Improvement in Human Semen Quality After Oral Supplementation of Vitamin C

Cited by 110 publications

References 14 publications

Physiological and Pathological Roles of Free Radicals in Male Reproduction

Physiological and Pathological Roles of Free Radicals in Male Reproduction

Dietary patterns and semen quality in young men

trans-resveratrol relaxes the corpus cavernosum ex vivo and enhances testosterone levels and sperm quality in vivo

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