Improvement in cholesterol metabolism in mice given chronic treatment of taurine and fed a high-fat diet

Murakami, Shigeru; Kondo-Ohta, Yukiko; Tomisawa, Kazuyuki

doi:10.1016/s0024-3205(98)00536-0

Cited by 81 publications

(72 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, there was no effect of taurine on the serum lipids, both when measured in the fasting state, during the euglycemic hyperinsulinemic clamp, or during the meal-test after intake of a high-fat breakfast. This is in contrast to the changes in LDL, HDL, total cholesterol and triglycerides after taurine supplementation, found by several investigators in animal studies (Cherif et al, 1998;Murakami et al, 1999Murakami et al, , 2000Murakami et al, , 2002. One potential reason why this effect was not observed in the present study could be that the bile salts in humans are reabsorbed more efficiently.…”

Section: Effect Of Taurine Treatment On Insulin Secretion and Action contrasting

confidence: 91%

See 1 more Smart Citation

Effect of taurine treatment on insulin secretion and action, and on serum lipid levels in overweight men with a genetic predisposition for type II diabetes mellitus

et al. 2004

View full text Add to dashboard Cite

Background: The prevalence of type 2 diabetes mellitus (T2DM) is increasing with an epidemic growth rate. Animal studies with taurine supplementation have shown increased insulin secretion and action, suggesting that taurine supplementation may have a potential to prevent T2DM. Objective: To assess the effect of taurine treatment on insulin secretion and action, and on plasma lipid levels in overweight men with a positive history of T2DM. Design: 20 nondiabetic subjects were included in a double-blinded, randomized, crossover study, receiving a daily supplementation of 1.5 g taurine or placebo for two periods of 8 weeks. The subjects were overweight first-degree relatives of T2DM patients. An intravenous glucose tolerance test (IVGTT) was used to measure first-phase insulin secretory response, and a euglycemic hyperinsulinemic clamp was used to determine peripheral insulin action. Results: Mean plasma taurine concentration was 3977 (s.d.) mmol/l after placebo and 131762 mmol/l after taurine intervention (Po0.0001). There was no significant difference after taurine intervention compared to placebo in incremental insulin response (Ins incr. ) neither during the IVGTT, nor in insulin-stimulated glucose disposal during the clamp. Insulin secretion, adjusted for insulin sensitivity, was also unchanged. There was no significant effect of taurine supplementation on blood lipid levels as well. Conclusion: Daily supplementation with 1.5 g taurine for 8 weeks had no effect on insulin secretion or sensitivity, or on blood lipid levels. These findings in persons with an increased risk of T2DM are in contrast to those from animal studies, and do not support the assumption that dietary supplementation with taurine can be used to prevent the development of T2DM.

show abstract

Section: Effect Of Taurine Treatment On Insulin Secretion and Action contrasting

confidence: 91%

“…In the study by Franconi et al (1995), the plasma taurine levels increased to slightly above the level of the control group, when a supplement of 1.5 g taurine per day for 90 days was given. Animal studies show that taurine also seems to have a lipid-lowering effect (Murakami et al, 1999(Murakami et al, , 2000(Murakami et al, , 2002.…”

Section: Introductionmentioning

confidence: 99%

Effect of taurine treatment on insulin secretion and action, and on serum lipid levels in overweight men with a genetic predisposition for type II diabetes mellitus

et al. 2004

View full text Add to dashboard Cite

show abstract

“…Taurine (2-aminoethane sulfonic acid), one of the most abundant free amino acids in many tissues, is well known to have several beneficial physiological actions, including antioxidation, detoxification, osmoregulation, cell membrane stabilization and neuromodulation (Wright et al, 1986;Huxtable, 1992). Several studies have demonstrated that dietary taurine showed a notable cholesterollowering effect in hypercholesterolemic rats fed a high cholesterol diet (Masuda and Horisaki, 1986;Murakami et al, 1999;Park and Lee, 1998;Hagar, 2004). It has been shown that taurine improves endothelial function and inhibits apoptosis of endothelial cell as well as decreases plasma level of LDL, which prevents initiation and progression of atherosclerosis (Fennessy et al, 2003;Murakami et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Taurine Attenuates Hepatic and Cardiac Damage and Apoptosis in Rabbits Fed a High-Fat Diet

Abdel-Rahman¹

2014

OnLine Journal of Biological Sciences

View full text Add to dashboard Cite

A hypercholesterolemia diet has been associated with the hepatic and cardiac abnormalities and the pathological changes. The present work was designed to investigate the histological and immunohistochemical changes in the liver and heart of rabbits when fed high fat diet and the possible protective role of an antioxidant "taurine". Twenty-four male white New Zealand rabbits were divided into four groups, 6 rabbits each. Group 1, served as a control, rabbits fed with a normal diet. Group 2, (taurine group), rabbits were given orally taurine (10 mg Kg −1 b.w/day) for 8 weeks. Group 3 (hypercholesterolemic group), rabbits fed (2% cholesterol-enriched diet for 8 weeks. Group 4, rabbits fed 2% cholesterol-enriched diet plus taurine (10 mg Kg −1 b.w/day) orally for the same period. Histopathological examinations revealed that high cholesterol diet caused hepatic and myocardial tissue changes compared with rabbits fed with a normal diet. Including fatty degeneration, inflammations and necrosis of Hepatocytes and vacuolar degeneration, disorganization of myofibrils and necrosis of myocardial cells. Immunohistochemistry for caspase-3 for apoptosis were performed. Caspase-3 positive cells in the liver tissue and Caspase-3 positive area in myocardial tissue increased in high cholesterol diet group. Taurine markedly attenuate hypercholesterolemia-induced cardiac and hepatic histopathological changes in the cholesterol plus taurine group compared to the cholesterol group. Thus, the results suggest that taurine could play a beneficial role against hypercholesterolemiainduced complications in the liver and heart of the rabbits.

show abstract

“…Providing taurine as 5% of the diet for 14 d significantly decreased concentrations of cholesterol, especially cholesteryl esters in both serum and liver. Ketone body production and incorporation of exogenous [1][2][3][4][5][6][7][8][9][10][11][12][13][14] C]oleate into ketone bodies in liver perfusate were consistently higher during a 4-h perfusion period in taurine-fed rats than in control rats. The elevation was accompanied by increased activity of liver mitochondrial carnitine palmitoyltransferase, a rate-limiting enzyme for fatty acid oxidation.…”

mentioning

confidence: 99%

Dietary Taurine Reduces Hepatic Secretion of Cholesteryl Ester and Enhances Fatty Acid Oxidation in Rats Fed a High-Cholesterol Diet

Fukuda

Yoshitama

Sugita

et al. 2011

J Nutr Sci Vitaminol

Self Cite

View full text Add to dashboard Cite

SummaryWe investigated the fate of exogenous fatty acid in connection with decreased hepatic accumulation and secretion of cholesteryl esters in rats fed diets containing taurine. Providing taurine as 5% of the diet for 14 d significantly decreased concentrations of cholesterol, especially cholesteryl esters in both serum and liver. Ketone body production and incorporation of exogenous [1][2][3][4][5][6][7][8][9][10][11][12][13][14] C]oleate into ketone bodies in liver perfusate were consistently higher during a 4-h perfusion period in taurine-fed rats than in control rats. The elevation was accompanied by increased activity of liver mitochondrial carnitine palmitoyltransferase, a rate-limiting enzyme for fatty acid oxidation. Dietary taurine significantly reduced hepatic secretion of cholesteryl ester and decreased incorporation of exogenous oleic acid substrate into this lipid molecule. Further, the extent of reduction in hepatic secretion of cholesteryl ester was closely related to its diminished accumulation in the liver. The conversion pattern of exogenous [1-14 C]oleic acid substrate suggested a decreased esterification-to-oxidation ratio in the taurine group compared with the control. These results suggest that taurine-induced reduction in hepatic accumulation of cholesteryl ester was associated with reduced hepatic secretion of this lipid molecule, and was inversely related to enhanced ketone body production and fatty acid oxidation. Key Words taurine, cholesterol ester secretion, fatty acid oxidation, rat liver Taurine, a sulfur-containing amino acid present in high concentrations in animal tissues, is available from dietary sources and also can be synthesized in vivo from other amino acids. Dietary taurine exhibits various physiologic and pharmacological actions, including hypocholesterolemic and antiatherogenic effects, in experimental animals, especially rats, mice, and Japanese (LAP) quail fed high cholesterol diets ( 1-6 ). These beneficial effects of taurine have recently been reproduced in humans ( 7 , 8 ). Although these effects have attracted attention, the underlying mechanisms are not clearly understood. With regard to the hypocholesterolemic action of dietary taurine, we previously reported that in rats fed high-cholesterol diets, the lowering of serum cholesterol by taurine was partly attributable to a reduced secretion rate of cholesteryl ester by the liver, and that reductions in hepatic secretion rate and in hepatic accumulation of cholesteryl ester were inversely related to increased ketone body production, an index of fatty acid oxidation ( 9 ). This pattern of changes suggested that dietary taurine influences the metabolic fate of fatty acids, specifically whether they undergo esterification or oxidation. However, in that study, we did not assess the relative significance of these two pathways in the metabolism of exogenous fatty acids.We therefore undertook a more detailed examination of fatty acid metabolism using an exogenous [1-14 C]oleic acid, and found for the first time that th...

show abstract

Improvement in cholesterol metabolism in mice given chronic treatment of taurine and fed a high-fat diet

Cited by 81 publications

References 35 publications

Effect of taurine treatment on insulin secretion and action, and on serum lipid levels in overweight men with a genetic predisposition for type II diabetes mellitus

Effect of taurine treatment on insulin secretion and action, and on serum lipid levels in overweight men with a genetic predisposition for type II diabetes mellitus

Taurine Attenuates Hepatic and Cardiac Damage and Apoptosis in Rabbits Fed a High-Fat Diet

Dietary Taurine Reduces Hepatic Secretion of Cholesteryl Ester and Enhances Fatty Acid Oxidation in Rats Fed a High-Cholesterol Diet

Contact Info

Product

Resources

About