Improvement and validation the method using dispersive liquid–liquid microextraction with in situ derivatization followed by gas chromatography–mass spectrometry for determination of tricyclic antidepressants in human urine samples

Ito, Rie; Ushiro, Masaru; Takahashi, Yuki; Saito, Koichi; Ookubo, Tetsuo; Iwasaki, Yusuke; Nakazawa, Hiroyuki

doi:10.1016/j.jchromb.2011.10.012

Cited by 76 publications

(28 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among the SSRIs, fluoxetine, citalopram, and sertraline are some of the most prescribed active principles . Furthermore, newer atypical antidepressants including target other neurotransmitters either alone or in addition to serotonin, such as venlafaxine, are currently administered and commonly prescribed worldwide . Nevertheless, a precise clinical monitoring to ensure patient's adherence to therapy and/or to individualize the dosage regimens is highly recommended to avoid therapeutic ineffectiveness or the occurrence of adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Determination of antidepressants in human urine extracted by magnetic multiwalled carbon nanotube poly(styrene‐co‐divinylbenzene) composites and separation by capillary electrophoresis

et al. 2018

View full text Add to dashboard Cite

Poly(styrene-co-divinylbenzene)-coated magnetic multiwalled carbon nanotube composite synthesized by in-situ high temperature combination and precipitation polymerization of styrene-co-divinylbenzene has been employed as a magnetic sorbent for the solid phase extraction of antidepressants in human urine samples. Fluoxetine, venlafaxine, citalopram and sertraline were, afterwards, separated and determined by capillary electrophoresis with diode array detection. The presence of magnetic multiwalled carbon nanotubes in native poly(styrene-co-divinylbenzene) not only simplified sample treatment but also enhanced the adsorption efficiencies, obtaining extraction recoveries higher than 89.5% for all analytes. Moreover, this composite can be re-used at least ten times without loss of efficiency and limits of detection ranging from 0.014 to 0.041 μg/mL were calculated. Additionally, precision values ranging from 0.08 to 7.50% and from 0.21 to 3.05% were obtained for the responses and for the migration times of the analytes, respectively.

show abstract

Section: Introductionmentioning

confidence: 99%

Determination of antidepressants in human urine extracted by magnetic multiwalled carbon nanotube poly(styrene‐co‐divinylbenzene) composites and separation by capillary electrophoresis

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Some examples use a simultaneous one-step derivatize-extract method, as in the analysis of anabolic steroids in a urinary sample matrix. 214 A push for cost saving methods for analyses that can simultaneous determine a range of pharmaceutical or personal care products from solutions have been developed by use of mixed derivatization reagent solvent system. 30,31 The authors state that there was no labor-intensive work in the derivatization step when care was taken with the choice of solvent to perform both the derivatization and extraction steps.…”

Section: Pharmaceuticalsmentioning

confidence: 99%

Analytical Derivatization Techniques ☆

Parkinson¹

2014

Reference Module in Chemistry, Molecular Sciences and Chemical Engineering

View full text Add to dashboard Cite

For the last 40 years or so, analytical chemists have borrowed well-known reaction techniques from organic and organometallic fields to perform derivatization reactions so as to enhance detection of the elusive analytes they seek. The derivatization mantra has been that, for the technique to be worthwhile, it should be simple to perform, fast (usually less than 15 min), selective, and that the derivatizing reagent should react quantitatively with the analyte and only give one final product. So where are we now? Some derivatization reactions are indeed fast and some are not; some are very selective and some are more universal. However, with a certain care and careful control of optimized conditions, quantitative enhancement outcomes and increased separative power and detection can be very worthwhile. The number of derivatization reagents commercially available itself suggests that there must be some merit to derivatization, that overcomes the associated extra costs: in time (to incorporate the extra reaction step), and in the expense of acquiring, handling, and storing derivatizing reagents. This chapter attempts to show that with proper consideration, it has been feasible to push a chosen analytical technique to give increased selective detection and signal enhancement by derivatization. In many cases, this has made possible the detection of trace components from difficult matrices in a number of scenarios, including on-site analysis, in quality control/continuous analysis methods, or through some remote-sensing platforms. Further, the incorporation of derivatization in an extraction method can be simple and friendly to automated throughput for multiple sample analysis.The fundamental idea of derivatization is that the basic chemical or physical structure of the analytical moiety is changed through a suitable reaction. For example, by labeling compounds for a specific detection purpose, or by changing a functional group to enhance certain chromatographic characteristics, better detection and separation (respectively) can be achieved via the ensuing instrumental techniques. The type of derivatization is highly dependent upon the analytical method and upon the nature of the compound analyzed. There are a variety of good review articles, technical reports, 1 text chapters, 2 and full texts 3-6 that address in detail many specific applications used in analytical derivatization. There are several extraction methods available that are compatible with derivatization. For many analyses, the choice of the best extraction technique is not clear, as many techniques can extract analytes equally well, based on simplicity, applicability, solvent use, expense, detection limit, precision, and time taken to perform the operation. 7 Derivatization techniques have been incorporated into many sample preparation and extractions schemes, to include, but not limited to, total sample headspace, single-drop microextraction (SDME), 8 solid-phase microextraction (SPME), needle trap device (NTD), purge and trap, solid-phase extraction (SPE)...

show abstract

“…Also, this method is time consuming due to the limited kinetics of the mass transfer process, and sample carryover is another problem. These shortcomings led to the development of liquid‐phase microextraction (LPME) , single drop microextraction , hollow fiber liquid‐phase microextraction (HF‐LPME) , and dispersive liquid–liquid microextraction (DLLME) . However, a fast stirring rate leads to the break up of the organic drop in single drop microextraction.…”

Section: Introductionmentioning

confidence: 99%

Solid-based disperser liquid-liquid microextraction for the preconcentration of phthalate esters and di-(2-ethylhexyl) adipate followed by gas chromatography with flame ionization detection or mass spectrometry

2014

View full text Add to dashboard Cite

A new approach for the development of a dispersive liquid-liquid microextraction followed by GC with flame ionization detection was proposed for the determination of phthalate esters and di-(2-ethylhexyl) adipate in aqueous samples. In the proposed method, solid and liquid phases were used as the disperser and extractant, respectively, providing a simple and fast mode for the extraction of the analytes into a small volume of an organic solvent. In this method, microliter levels of an extraction solvent was added onto a sugar cube and it was transferred into the aqueous phase containing the analytes. By manual shaking, the sugar was dissolved and the extractant was released into the aqueous phase as very tiny droplets to provide a cloudy solution. Under optimized conditions, the proposed method showed good precision (RSD less than 5.2%), high enrichment factors (266-556), and low LODs (0.09-0.25 μg/L). The method was successfully applied for the determination of the target analytes in different samples, and good recoveries (71-103%) were achieved for the spiked samples. No need for a disperser solvent and higher enrichment factors compared with conventional dispersive liquid-liquid microextraction and low cost and short sample preparation time are other advantages of the method.

show abstract

Improvement and validation the method using dispersive liquid–liquid microextraction with in situ derivatization followed by gas chromatography–mass spectrometry for determination of tricyclic antidepressants in human urine samples

Cited by 76 publications

References 27 publications

Determination of antidepressants in human urine extracted by magnetic multiwalled carbon nanotube poly(styrene‐co‐divinylbenzene) composites and separation by capillary electrophoresis

Determination of antidepressants in human urine extracted by magnetic multiwalled carbon nanotube poly(styrene‐co‐divinylbenzene) composites and separation by capillary electrophoresis

Analytical Derivatization Techniques ☆

Solid-based disperser liquid-liquid microextraction for the preconcentration of phthalate esters and di-(2-ethylhexyl) adipate followed by gas chromatography with flame ionization detection or mass spectrometry

Contact Info

Product

Resources

About