Improvement and retardation of wound healing: effects of pharmacological agents in laboratory animal studies

Abstract

Impaired wound healing is an important problem; retardation of healing may be induced by endogenous and/or exogenous factors and treatments capable of ameliorating these eects are needed. The eects of solutions containing light ichthyol or povidone iodine, of ointments containing zinc oxide (ZO) and/ or cod liver oil (CLO), and of a polyurethane-hydrogel foam wound dressing were examined on healing of full-thickness murine skin wounds impaired by systemic dexamethasone. The eects of the ointments were also studied on murine skin ulceration induced by subcutaneous sodium dodecyl sulphate solution. Light ichthyol at 1% and 2% but not at 5% and 10%, povidone iodine at 1% and the foam accelerated impaired healing. The ointments containing ZO or CLO accelerated healing of impaired full-thickness wounds and of ulcerated skin; ZO and CLO were synergistic. These studies demonstrate the value of murine models in the evaluation of agents employed in veterinary wound dressings.

Evaluation of Therapeutic Intervention with a Natural Product in Cutaneous Wound Healing: The Use of Capybara Oil

“…The topical application of 25% cod liver oil ointment, which is rich in polyunsaturated fatty acids, was shown to accelerate the epithelial and vascular components of healing in mice [6] and to accelerate healing by reducing the wounded area [17]. Moreover, topically applied emu [7] and crocodile [8] oils accelerated the healing of rat burns.…”

Comparison of topical zinc oxide and silver sulfadiazine in burn wounds: an experimental study

“…[27][28][29] Topical application of zinc decreases the rate of debris and necrotic material and increases the epithelization. [30][31][32][33] According to Kietzmann, [35] locally applied zinc accelerates the healing of ulcerated skin. According to various randomized controlled studies, topical application of zinc has beneficial effects on leg ulcers, pressure ulcers and diabetic foot ulcers.…”

Zinc in wound healing: Theoretical, experimental, and clinical aspects

“…86,116 Locally applied zinc oxide also enhanced the repair of ulcerated skin. 117 Conversely, inhibition of MMPs dramatically delays wound healing. 98 Strong support is given in recent experimental studies to show that added zinc aids surgical wound repair 113,118 and that induced or hereditary zinc deficiency is detrimental.…”