Comparison of topical zinc oxide and silver sulfadiazine in burn wounds: an experimental study

Arslan, Kemal; Karahan, Ömer; Okuş, Ahmet; Ünlü, Yaşar; Eryılmaz, Mehmet Ali; Ay, Serden; Sevinç, Barış

doi:10.5505/tjtes.2012.45381

Cited by 24 publications

(27 citation statements)

References 33 publications

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“…Most studies of topical agents have compared their effects on burn wound healing with those of silver sulfadiazine cream . We did not compare topical piracetam with silver sulfadiazine cream because our aim was to investigate only the beneficial effects of nimodipine and piracetam on full‐thickness burn wound healing.…”

Section: Discussionmentioning

confidence: 99%

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Effect of piracetam and nimodipine on full‐thickness skin burns in rabbits

Sarı

Dinçel

2015

International Wound Journal

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The potential of several drugs for full-thickness skin burns has been investigated, but the treatment of such burns remains a challenge in plastic surgery. The present study was designed to determine the effect of systemic and topical administration of piracetam and nimodipine on full-thickness skin burn wound healing. A total of 36 New Zealand male rabbits were divided into six groups. Full-thickness skin burns were produced in all the groups, except the control group. Piracetam was administered systemically (piracetam-IV) and topically (piracetam-C) for 14 days, and nimodipine was administered systemically (nimodipine-IV) and topically (nimodipine-C) over the burn wounds for 14 days. The sham group underwent burn injury but was not administered any drug. After 21 days, gross examination and histopathological analysis were performed and the results were compared statistically. Nimodipine-C and nimodipine-IV had no effect on burn wound healing. However, both piracetam-IV and piracetam-C significantly enhanced the healing of the full-thickness skin burn wounds, although the latter was more effective, useful and practical in burn wound healing. The histopathological features of the wounds in the piracetam-C group were closer to those of the control group than those of the other groups. Piracetam-C rather than piracetam-IV may promote full-thickness burn wound healing in rabbits.

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Section: Discussionmentioning

confidence: 99%

“…Several herbal products and medicines have been used to accelerate the healing period of burn wounds. These include olive oil , topical aqueous oxygen , topical zinc oxide , topical aloe vera extract and silver sulfadiazine . Among these, silver sulfadiazine is the most widely used agent worldwide .…”

Section: Introductionmentioning

confidence: 99%

Effect of piracetam and nimodipine on full‐thickness skin burns in rabbits

Sarı

Dinçel

2015

International Wound Journal

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“…The measurements of the burn areas were evaluated using the NIH ImageJ program as described in our previous study. [6] The percentage of re-epithelization was calculated as follows:…”

Section: Introductionmentioning

confidence: 99%

Comparison of Ankaferd Blood Stoper and Silver Sulfadiazine use in burn wounds: Experimental study.

Ünlü

2019

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: The present study was designed to compare the effectiveness of topical silver sulfadiazine (SSD) and Ankaferd Blood Stopper ® (ABS) usage in experimental partial-thickness burns in rats. METHODS: Twenty-one male Wistar albino rats weighing 250-290 (range: 270±19) g were used in the present study. A round brass probe that was specifically designed (3×3 cm diameter) was used to induce the burns in rats. After the presence of partial-thickness burns was confirmed, the rats were divided into three groups: Group 1 (ABS group) Ankaferd Blood Stopper ® pad, Group 2 (SSD group) silver sulfadiazine (Silverdin ®), and Group 3 (Control group) 1% isotonic saline solution-impregnated pad. The healing period was followed up clinically and histopathologically. The day on which 50% and 80% of re-epithelization at first were detected for each rat was also recorded. RESULTS: The mean times of 50% and 80% of re-epithelization at first were 10.8 days, 13.8 days, and 16.8 days in Groups 1, 2, and 3, respectively (p<0.001), and 16.4 days, 19.7 days, and 25.2 days, respectively (p<0.001). The mean inflammatory scores were also found to be better in the ABS group than in other groups (p<0.05). CONCLUSION: Our study showed that ABS has better results for the healing of the burn wound than SSD in experimental partialthickness burns in rats.

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“…Unfortunately, evidence exists that the use of AgSD places patients at increased risk of many undesirable effects. It was also found that AgSD may lead to prolongation of the wound reepithelialization process as well as to decreased mechanical strength of the dermal tissue [2]. The previous side effects were not observed after burns treatment with propolis.…”

Section: Introductionmentioning

confidence: 99%

Propolis Induces Chondroitin/Dermatan Sulphate and Hyaluronic Acid Accumulation in the Skin of Burned Wound

Olczyk

Komosińska-Vassev

Winsz-Szczotka

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Changes in extracellular matrix glycosaminoglycans during the wound repair allowed us to apply the burn model in which therapeutic efficacy of propolis and silver sulfadiazine was compared. Burns were inflicted on four pigs. Glycosaminoglycans isolated from healthy and burned skin were quantified using a hexuronic acid assay, electrophoretic fractionation, and densitometric analyses. Using the reverse-phase HPLC the profile of sulfated disaccharides released by chondroitinase ABC from chondroitin/dermatan sulfates was estimated. Chondroitin/dermatan sulfates and hyaluronic acid were found in all samples. Propolis stimulated significant changes in the content of particular glycosaminoglycan types during burn healing. Glycosaminoglycans alterations after silver sulfadiazine application were less expressed. Propolis maintained high contribution of 4-O-sulfated disaccharides to chondroitin/dermatan sulfates structure and low level of 6-O-sulfated ones throughout the observed period of healing. Propolis led to preservation of significant contribution of disulfated disaccharides especially 2,4-O-disulfated ones to chondroitin sulfates/dermatan sulfates structure throughout the observed period of healing. Our findings demonstrate that propolis accelerates the burned tissue repair by stimulation of the wound bed glycosaminoglycan accumulation needed for granulation, tissue growth, and wound closure. Moreover, propolis accelerates chondroitin/dermatan sulfates structure modification responsible for binding growth factors playing the crucial role in the tissue repair.

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Comparison of topical zinc oxide and silver sulfadiazine in burn wounds: an experimental study

Cited by 24 publications

References 33 publications

Effect of piracetam and nimodipine on full‐thickness skin burns in rabbits

Effect of piracetam and nimodipine on full‐thickness skin burns in rabbits

Comparison of Ankaferd Blood Stoper and Silver Sulfadiazine use in burn wounds: Experimental study.

Propolis Induces Chondroitin/Dermatan Sulphate and Hyaluronic Acid Accumulation in the Skin of Burned Wound

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