Improved survival of colon cancer due to improved treatment and detection: a nationwide population-based study in The Netherlands 1989–2006

Steenbergen, L.N. van; Elferink, M.A.G.; Krijnen, Pieta; Lemmens, Valery; Siesling, Sabine; Rutten, H.J.T.; Richel, D. J.; Karim‐Kos, Henrike E.; Coebergh, Jan Willem

doi:10.1093/annonc/mdq227

Cited by 101 publications

(84 citation statements)

References 26 publications

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“…These changes include centralized and improved surgery, multidisciplinary teams [3][4][5], preoperative radiotherapy in rectal cancer [9,10] and more precise adjuvant treatments [6][7][8]. However, also the regional healthcare systems have changed accordingly, and based on a single clinical trial or study registry, it is challenging to analyze the impact of different changes in the treatment results of CRC.…”

Section: Discussionmentioning

confidence: 99%

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Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study

et al. 2017

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Background: Most survival data in colorectal cancer (CRC) is derived from clinical trials or registerbased studies. Hospital Biobanks, linked with hospital electronic records, could serve as a data-gathering method based on consecutively collected tumor samples. The aim of this Biobank study was to analyze survival of colorectal patients diagnosed and treated in a single-center university hospital over a period of 12 years, and to evaluate factors contributing to outcome.

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Section: Discussionmentioning

confidence: 99%

“…Controlled quality and centralization of surgery, both in rectal [3,4] and colon cancer [5] and the use of adjuvant chemotherapy [6][7][8] have improved the survival of patients with CRC. Additionally, in rectal cancer, preoperative radiotherapy or chemoradiotherapy have significantly improved survival [9,10].…”

Section: Introductionmentioning

confidence: 99%

Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study

et al. 2017

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“…Oral analogues of fluorouracil (capecitabine) as an alternative to intravenous 5-FU/folinic acid, for example, have led to less costly delivery. In addition, in European countries, rates of utilisation of chemotherapy in colorectal cancer have increased substantially over time [54,55]. In Ireland, in 1994, 20% of patients received chemotherapy rising to more than 35% of colon cancer patients and almost 50% of rectal cancer patients by 2002 [56].…”

Section: Chemotherapy and Biological Agentsmentioning

confidence: 99%

Cost of care for colorectal cancer in Ireland: a health care payer perspective

et al. 2011

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“…With a continuously rising incidence, an estimated 1.35 million new cases are diagnosed yearly, associated with 694 000 annual deaths. In the past decades, substantial progress has been made in diagnosis and treatment of CRC, resulting in an increasing number of CRC survivors [2][3][4][5][6][7][8]. The implementation of national CRC screening programs is expected to increase the incidence of CRC [9].…”

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confidence: 99%

Prospective Dutch colorectal cancer cohort: an infrastructure for long-term observational, prognostic, predictive and (randomized) intervention research

et al. 2016

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Background: Systematic evaluation and validation of new prognostic and predictive markers, technologies and interventions for colorectal cancer (CRC) is crucial for optimizing patients' outcomes. With only 5-15% of patients participating in clinical trials, generalizability of results is poor. Moreover, current trials often lack the capacity for post-hoc subgroup analyses. For this purpose, a large observational cohort study, serving as a multiple trial and biobanking facility, was set up by the Dutch Colorectal Cancer Group (DCCG). Methods/design: The Prospective Dutch ColoRectal Cancer cohort is a prospective multidisciplinary nationwide observational cohort study in the Netherlands (yearly CRC incidence of 15 500). All CRC patients (stage I-IV) are eligible for inclusion, and longitudinal clinical data are registered. Patients give separate consent for the collection of blood and tumor tissue, filling out questionnaires, and broad randomization for studies according to the innovative cohort multiple randomized controlled trial design (cmRCT), serving as an alternative study design for the classic RCT. Objectives of the study include: 1) systematically collected long-term clinical data, patient-reported outcomes and biomaterials from daily CRC practice; and 2) to facilitate future basic, translational and clinical research including interventional and cost-effectiveness studies for both national and international research groups with short inclusion periods, even for studies with stringent inclusion criteria. Results: Seven months after initiation 650 patients have been enrolled, eight centers participate, 15 centers await IRB approval and nine embedded cohort-or cmRCT-designed studies are currently recruiting patients. Conclusion: This cohort provides a unique multidisciplinary data, biobank, and patient-reported outcomes collection initiative, serving as an infrastructure for various kinds of research aiming to improve treatment outcomes in CRC patients. This comprehensive design may serve as an example for other tumor types.

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Improved survival of colon cancer due to improved treatment and detection: a nationwide population-based study in The Netherlands 1989–2006

Abstract: There were substantial improvements in management and survival of colon cancer from 1989 to 2006. Stage III disease patients with colon cancer experienced the largest improvement in survival, most likely related to the increased administration of adjuvant chemotherapy.

Cited by 101 publications

References 26 publications

Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study

Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study

Cost of care for colorectal cancer in Ireland: a health care payer perspective

Prospective Dutch colorectal cancer cohort: an infrastructure for long-term observational, prognostic, predictive and (randomized) intervention research

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