Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study

Heervä, Eetu; Carpelan, Anu; Kurki, Samu; Sundström, Jari; Huhtinen, Heikki; Rantala, Arto; Ålgars, Annika; Ristamäki, Raija; Carpén, Olli; Minn, Heikki

doi:10.1080/0284186x.2017.1420230

Cited by 7 publications

(5 citation statements)

References 32 publications

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“…Others have similarly reported improvements in overall and disease-free survival for patients with rectal cancer from 2001 to 2012, noting that this is likely due to preoperative radiation therapy and chemotherapy. 43 We also found that improvements in proximal colon cancer survival in blacks lagged far behind those in whites. The fact that survival disparities by race persist only in colon cancer could reflect differences in tumor biology and treatment response.…”

Section: Discussionsupporting

confidence: 50%

Racial Disparities in Incidence of Young-Onset Colorectal Cancer and Patient Survival

et al. 2019

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From 1992-1996 [ ] to 2010-2014 [ ], increases in young-onset colorectal cancer have been largely due to increases in rectal cancer, especially in whites. In the most time recent period, blacks and whites have similar incidence and survival of rectal cancer, a sharp contrast to the striking disparities in colon cancer. 1 1.5 2 2.5 3 3.5 4 4.5 5 30 40 50 60 70 80 90 100 Whites, rectum Blacks, rectum Whites, distal colon Blacks, distal colon Whites, proximal colon Blacks, proximal colon Incidence per 100,000 Five-year relative survival (%) See editorial on page 858. BACKGROUND & AIMS: Increasing rates of young-onset colorectal cancer (CRC) have attracted substantial research and media attention, but we know little about racial disparities among younger adults with CRC. We examined racial disparities in young-onset CRC by comparing CRC incidence and relative survival among younger (<50-year-old) adults in 2 time periods. METHODS: Using data from the Surveillance, Epidemiology, and End Results program of cancer registries, we estimated CRC incidence rates (per 100,000 persons 20-49 years old) from 1992 through 2014 for different periods (1992-1996 vs 2010-2014) and races (white vs black). Relative survival was calculated as the ratio of observed survival to expected survival in a comparable cancer-free population. RESULTS: From 1992-1996 to 2010-2014, CRC incidence increased from 7.5 to 11.0 per 100,000 in white individuals and from 11.7 to 12.7 per 100,000 in black individuals. The increase in rectal cancer was larger in whites (from 2.7 to 4.5 per 100,000) than in blacks (from 3.4 to 4.0 per 100,000); in the 2010-2014 period, blacks and whites had similar rates of rectal cancer. Compared with whites, blacks had smaller increases in relative survival with proximal colon cancer but larger increases in survival with rectal cancer (from 55.3% to 70.8%). CONCLUSION: In an analysis of the Surveillance, Epidemiology, and End Results database, we found racial disparities in incidence of young-onset CRC and patient survival for cancer of the colon but minimal difference for rectal cancer. Well-documented and recent increases in young-onset CRC have largely been due to increases in rectal cancer, especially in whites.

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Section: Discussionsupporting

confidence: 50%

Racial Disparities in Incidence of Young-Onset Colorectal Cancer and Patient Survival

et al. 2019

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“…Overall survival was assessed using Kaplan-Meir and the results showed median survival was 9.4 months. This was much lower compared with other studies conducted in developed countries, which shows trends towards survival improvement in CRC patients [18].…”

Section: Discussioncontrasting

confidence: 67%

“…Potential factors contributing to the improvement were introduction of multidisciplinary meetings, centralization of rectal cancer surgery, and use of adjuvant chemotherapy and systemic preoperative radiotherapy of rectal cancer. In this study left-sided primary tumors had longer OS, specifically stage III disease the median OS was 7.6 years compared to 3.5 years for patient with right-sided tumor [18].…”

Section: Discussionmentioning

confidence: 51%

Clinical-Pathological Characteristics of Colorectal Carcinoma and Factors Influence 2-Years Survival among Patients Attending Ocean Road Cancer Institute Dar es Salaam Tanzania

Lulabuka¹,

Dharsee²,

Kahesa³

et al. 2019

OJGas

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Background: Colorectal carcinoma usually arises from an adenomatous polyp and observational studies suggest that the adenoma-to-carcinoma sequence takes approximately 10 to 15 years. Risk factors are adoption of westernized diets, obesity, cigarette smoking, and alcohol and reduced physical activity. Clinical Presentations are blood per rectum, abdominal pain, Anemia, change in bowel habits and bowel obstructive symptoms. The treatment of colorectal cancer is a dependent stage which includes chemotherapy, radiotherapy, surgery or both. Objective: This study aims at describing the clinical pathological characteristics of colorectal carcinoma and factors influencing survival among patients treated at Ocean Road Cancer Institute. Methods: This was a cross sectional study that involved histological confirmed colorectal carcinoma treated at Ocean Road Cancer Institute from 2010-2015. Results: Among 100 files extracted, 63% were males and 37% females. 21% were below 40 years of age. Left-sided tumor accounted for 46%. Abdominal pain, rectal bleeding and constipation were 72%, 68% and 55% respectively. Moderately differentiated adenocarcinoma accounted for 80%. Patients presented at stage III and IV were 37% and 56% respectively. Colostomy was the most surgical procedures performed. Folinic acid, Fluorouracil and Oxaliplatin were the most common chemotherapies used. Median overall survival was estimated to be 9.4 months. Conclusion: A significant proportion of patients in this study population are young. Survival from colorectal cancer is poor owing largely to the late presentation seen in this study group.

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“…As the included patients were long-term survivors of rectal carcinoma, the proportion of patients who had received CRT (4%) or RT (25%) in this study was unusually low ( Table 1 ). During the same time frame, 51% of all patients with rectal adenocarcinoma treated in our hospital received CRT or RT 26 . This reflects the correct use of radiotherapy for patients with bad and ugly tumors only 27 , who unfortunately also have shorter overall survival or need an abdominoperineal excision instead of anterior resection.…”

Section: Discussionmentioning

confidence: 99%

Validation of the low anterior resection syndrome score in finnish patients: preliminary results on quality of life in different lars severity groups

et al. 2020

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Background and Aims: Low anterior resection syndrome is common after anterior resection for rectal cancer. Its severity can be tested with the low anterior resection syndrome score. We have translated the low anterior resection syndrome score to Finnish, and the aim of this study is to validate the translation. Materials and Methods: The translated Finnish low anterior resection syndrome score and European Organisation for Research and Treatment of Cancer quality-of-life questionnaire-C30 and QLQ-CR29 questionnaires were sent to 159 surviving patients operated with anterior resection for rectal adenocarcinoma between 2007 and 2014 in a tertiary referral center. Psychometric properties of the translation were evaluated in comparison to quality-of-life scales and in different risk factor groups. Results: In the study, 104 (65%) patients returned the questionnaires. Of these, 56 (54%) had major low anterior resection syndrome, 26 (25%) had minor low anterior resection syndrome, and 22 (21%) had no low anterior resection syndrome. Patients with major low anterior resection syndrome had a significantly lower quality of life and more defecatory symptoms as assessed with the European Organisation for Research and Treatment of Cancer questionnaires compared with those with no low anterior resection syndrome. Patients operated with total mesorectal excision had significantly higher low anterior resection syndrome scores compared with those operated with partial mesorectal excision (median/interquartile range 32/15 and 29/11, respectively, p = 0.037). The test–retest validity of the translation was good with an intraclass correlation coefficient of 0.77 (95% confidence interval 0.51–0.90). Conclusion: The Finnish low anterior resection syndrome score is a valid test in the assessment of postoperative bowel function and its impact on the quality of life. It can be implemented to use during regular follow-up visits of Finnish-speaking rectal cancer patients.

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Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study

Cited by 7 publications

References 32 publications

Racial Disparities in Incidence of Young-Onset Colorectal Cancer and Patient Survival

Racial Disparities in Incidence of Young-Onset Colorectal Cancer and Patient Survival

Clinical-Pathological Characteristics of Colorectal Carcinoma and Factors Influence 2-Years Survival among Patients Attending Ocean Road Cancer Institute Dar es Salaam Tanzania

Validation of the low anterior resection syndrome score in finnish patients: preliminary results on quality of life in different lars severity groups

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