Burkitt's lymphoma, resembling the African variety, occurred in 16 Saudi Arabian children seen at the King Faisal Specialist Hospital and Research Centre over a period of five years. The age range was from 3 to 12 years and the median age was 4.5 years. Weight loss, anorexia, abdominal pain, and chewing difficulty were the most frequent presenting complaints. The abdominal viscera and the facial bones were the commonest sites of initial involvement. Renal parenchymal infiltration with subsequent acute renal failure was a prominent feature in these patients. The majority of patients came from the Southern and Southwestern parts of Saudi Arabia and their disease occurred during the rainy season. These findings, contrary to previously published reports, indicate Burkitt's lymphoma does exist in Saudi Arabia and that it exhibits space-time clustering as was originally observed in some parts of Africa.