Improved Stability and Photothermal Performance of Polydopamine‐Modified Fe₃O₄ Nanocomposites for Highly Efficient Magnetic Resonance Imaging‐Guided Photothermal Therapy

Abstract

Magnetic nanomaterials are a promising class of contrast agents for magnetic resonance imaging (MRI). However, their poor stability and low relaxivity are major challenges hindering their clinical applications. In this study, magnetic theranostic nanoagents based on polydopamine‐modified Fe3O4 (Fe3O4@PDA) nanocomposites are fabricated for MRI‐guided photothermal therapy (PTT) cancer treatments. Their high transverse relaxivity of 337.8 mM−1 s−1 makes these Fe3O4@PDA nanocomposites a promising T2‐weighted MRI contrast agent for cancer diagnosis and image‐guided cancer therapy. Due to the good photothermal effect of polydopamine (PDA), the tumors of 4T1 tumor‐bearing mice are completely excised by PTT. Most importantly, the PDA shell also improves the stability of the Fe3O4@PDA nanocomposites, which contributes to their excellent, long‐term performance in MRI and PTT applications. Their good stability, high T2 relaxivity, robust biocompatibility, and satisfactory treatment effect give these Fe3O4@PDA nanocomposites great potential for use in cancer theranostics.

Near‐Infrared Light‐Regulated Drug‐Food Homologous Bioactive Molecules and Photothermal Collaborative Precise Antibacterial Therapy Nanoplatform with Controlled Release Property

“…The presence of N element was derived from PDA, indicating the successful formation of PDA coating on the surface of Cu‐GA‐CA‐PDA NRs. [ 23 ] In addition, the XPS analysis revealed that there were three strong Cu 2+ satellites at 962.17, 943.47, and 940.17 eV in the Cu 2p spectra of Cu‐GA‐CA NSs and Cu‐GA‐CA‐PDA NRs, which were similar to some previous reports. [ 24 ] The peaks at 954.07 and 934.17 could be assigned to Cu 2p 1/2 and Cu 2p 3/2 , respectively (Figure 3i).…”

Magnetic Hyperthermia on γ-Fe2O3@SiO2 Core-Shell Nanoparticles for mi-RNA 122 Detection

“…Chemical functions charged at pH 7.4 (amine, carboxylic acid) and polymer PEG chains bring electrostatic and steric repulsions ensuring high colloidal stability in biological media [ 10 ] Moreover, another advantage of a silica layer is to limit dipolar interactions between the magnetic particles [ 11 ]. Polydopamine coating is an alternative strategy also studied, showing promising results, notably to combine magnetic resonance imaging and photothermal therapy, due to the good photothermal effect of polydopamine [ 12 ].…”

Rational Constructed Ultra-Small Iron Oxide Nanoprobes Manifesting High Performance for T1-Weighted Magnetic Resonance Imaging of Glioblastoma

“…Magnetic resonance imaging (MRI) has been demonstrated as a powerful technique for the visualization of the anatomical structure with high spatial resolution [1][2][3]. Compared with computed tomography (CT) [4], positron emission tomography (PET), and single photon emission computed tomography (SPECT) [5], MRI offers several advantages including excellent soft-tissue contrast, the absence of potentially destructive ionizing radiation, and multi-functional imaging with diverse applications [6][7][8].…”