Improved sedation for oral surgery by combining nitrous oxide and intravenous Midazolam: a randomized, controlled trial

Conscious Sedation Procedures Using Intravenous Midazolam for Dental Care in Patients with Different Cognitive Profiles: A Prospective Study of Effectiveness and Safety

“…This is useful for those patients who respond more markedly to the hypnotic and depressive effects of midazolam than to its anxiolytic effects. Accordingly, some authors showed that when nitrous oxide was associated with midazolam for oral surgery there was a significant reduction in the amount of midazolam required, a significant reduction in recovery time, and a significant improvement in cooperation and arterial oxygen saturation [42].…”

Investigation of inhalational conscious sedation as a tool for reducing anxiety in adults undergoing exodontia

“…Standardising the groups would not be possible without a randomised controlled trial but this is hardly ethical when treating moderate to severely anxious patients who require sedation, a sentiment echoed by Zacny et al 15 This was also well demonstrated in Venchard et al's work when they were unable to randomise surgical patients into an IHS group and had to abandon this part of their study because the patients had been unable to have their surgical treatment completed. 20 This evaluation effectively demonstrates that it is entirely possible to treat patients surgically with IHS alone, providing they are adequately assessed and selected pre-operatively.…”

A Prospective, Randomized Controlled Trial of Conscious Sedation Using Propofol Combined With Inhaled Nitrous Oxide for Dental Treatment

“…Currently, the effect of supplemental nitrous oxide on recovery time remains controversial. Venchard et al 29 reported finding a reduced recovery time when supplemental nitrous oxide was added to intravenous sedation with midazolam. Similar results were found by Lahoud and Hopkins.…”