Improved sample treatment for the determination of 17 strong sorbed quinolone antibiotics from compost by ultra high performance liquid chromatography tandem mass spectrometry

Dorival-García, Noemí; Labajo-Recio, C.; Zafra-Gómez, A.; Juárez-Jiménez, B.; Vı́lchez, J.L.

doi:10.1016/j.talanta.2015.03.011

Cited by 48 publications

(22 citation statements)

References 41 publications

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“…Amongst these pharmaceuticals, fluoroquinolones were the most abundant, with concentrations reaching thousands of micrograms per kilogramme dw. Such high concentrations were consistent with previous observations [2,6,13,17]. The bactericide triclosan, which presents ecotoxic activity, was also abundant in sludge no.…”

Section: Analysis Of Environmental Samplessupporting

confidence: 92%

“…The other pharmaceuticals that were detected at lower levels (doxycycline, sulfamethoxazole, fluoxetine, carbamazepine, diclofenac, ibuprofen) were also in accordance with previous studies [2,6,12,15,21]. The concentrations were globally in the same range in sludge samples and digested sludge and were much lower in the GWS compost as previously observed [13,22], probably due to the dilution effect by the addition of green wastes. In the soil regularly amended with the GWS compost and sampled 1 month after the last application, the fluoroquinolones that are highly persistent [6] were the most abundant, as in the GWS compost, but the concentrations in the soil were below 10 μg/ kg dw.…”

Section: Analysis Of Environmental Samplessupporting

confidence: 90%

“…For the extraction of pharmaceuticals from solid samples, very different compositions of liquid media have been proposed, containing mixtures of organic solvents, buffers and chelating agents [1,2,[10][11][12][13][14][15][16]. This wide range of proposed extraction conditions is due to the fact that (i) the methods were developed using a step-by-step approach, with which only a relative optimum is found and the best experimental conditions can be missed, since one factor varies whilst the others are kept constant [1,12,14,15,[17][18][19][20][21][22], and/or (ii) the methods were developed for restricted numbers of pharmaceutical groups, such as pharmaceuticals with similar physical-chemical properties [e.g.…”

Section: Introductionmentioning

confidence: 99%

“…This wide range of proposed extraction conditions is due to the fact that (i) the methods were developed using a step-by-step approach, with which only a relative optimum is found and the best experimental conditions can be missed, since one factor varies whilst the others are kept constant [1,12,14,15,[17][18][19][20][21][22], and/or (ii) the methods were developed for restricted numbers of pharmaceutical groups, such as pharmaceuticals with similar physical-chemical properties [e.g. 1,13,17,18]. As a consequence, it is difficult to choose the best method amongst those published, for extracting a wide variety of pharmaceutical compounds simultaneously.…”

Section: Introductionmentioning

confidence: 99%

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Factors influencing the extraction of pharmaceuticals from sewage sludge and soil: an experimental design approach

et al. 2016

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Pharmaceuticals can enter the environment when organic waste products are recycled on agricultural soils. The extraction of pharmaceuticals is a challenging step in their analysis. The very different extraction conditions proposed in the literature make the choice of the right method for multi-residue analysis difficult. This study aimed at evaluating, with experimental design methodology, the influence of the nature, pH and composition of the extraction medium on the extraction recovery of 14 pharmaceuticals, including 8 antibiotics, from soil and sewage sludge. Preliminary experimental designs showed that acetonitrile and citrate-phosphate buffer were the best extractants. Then, a response surface design demonstrated that many cross-product and squared terms had significant effects, explaining the shapes of the response surfaces. It also allowed optimising the pharmaceutical recoveries in soil and sludge. The optimal conditions were interpreted considering the ionisation states of the compounds, their solubility in the extraction medium and their interactions with the solid matrix. To perform the analysis, a compromise was made for each matrix. After a QuEChERS purification, the samples were analysed by online SPE-UHPLC-MS-MS. Both methods were simple and economical. They were validated with the accuracy profile methodology for soil and sludge and characterised for another type of soil, digested sludge and composted sludge. Trueness globally ranged between 80 and 120 % recovery, and inter- and intra-day precisions were globally below 20 % relative standard deviation. Various pharmaceuticals were present in environmental samples, with concentration levels ranging from a few micrograms per kilogramme up to thousands of micrograms per kilogramme. Graphical abstract Influence of the extraction medium on the extraction recovery of 14 pharmaceuticals. Influence of the ionisation state, the solubility and the interactions of pharmaceuticals with solid matrix. Analysis of different soils and organic waste products.

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Section: Analysis Of Environmental Samplessupporting

confidence: 92%

Section: Analysis Of Environmental Samplessupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Factors influencing the extraction of pharmaceuticals from sewage sludge and soil: an experimental design approach

et al. 2016

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“…Although only very few data are available in the literature, FQs have been detected in compost at the nanograms per gram levels [1,4,33]. It seems evident that using compost in agriculture represents an important route for FQs environmental pollution.…”

Section: Introductionmentioning

confidence: 99%

Fluoroquinolone residues in compost by green enhanced microwave-assisted extraction followed by ultra performance liquid chromatography tandem mass spectrometry

Speltini

Sturini

Maraschi

et al. 2015

Journal of Chromatography A

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Simultaneous extraction and determination of antibiotics in soils using a method based on quick, easy, cheap, effective, rugged, and safe extraction and liquid chromatography with tandem mass spectrometry

Meng

et al. 2017

J of Separation Science

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The increasing use of antibiotics has caused substantial environmental problems, which are a matter of great concern. The aim of this work was to develop a quick, easy, cheap, effective, rugged, and safe method for 20 antibiotic residues in soil. The developed method is based on extraction with acetonitrile and phosphate buffer, clean up with dispersive solid-phase extraction adsorbent using primary secondary amine, octadecylsilane, followed by liquid chromatography with tandem mass spectrometry determination. We optimized different extraction methods and the ratio of cleanup adsorbents to achieve good recoveries at seven spiking levels that ranged from 61.4 to 118.9% with a relative standard deviation below 20% (n = 5). The method quantification limit was in the range of 2-5 μg/kg for most analytes. Good linear regression coefficients greater than 0.990 were obtained. This method was applied for the analysis of real agricultural soil samples, confirming the feasibility of the method.

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Improved sample treatment for the determination of 17 strong sorbed quinolone antibiotics from compost by ultra high performance liquid chromatography tandem mass spectrometry

Cited by 48 publications

References 41 publications

Factors influencing the extraction of pharmaceuticals from sewage sludge and soil: an experimental design approach

Factors influencing the extraction of pharmaceuticals from sewage sludge and soil: an experimental design approach

Fluoroquinolone residues in compost by green enhanced microwave-assisted extraction followed by ultra performance liquid chromatography tandem mass spectrometry

Simultaneous extraction and determination of antibiotics in soils using a method based on quick, easy, cheap, effective, rugged, and safe extraction and liquid chromatography with tandem mass spectrometry

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