Factors influencing the extraction of pharmaceuticals from sewage sludge and soil: an experimental design approach

Ferhi, Sabrina; Bourdat-Deschamps, Marjolaine; Daudin, Jean‐Jacques; Houot, Sabine; Nélieu, Sylvie

doi:10.1007/s00216-016-9725-3

Cited by 39 publications

(25 citation statements)

References 36 publications

(91 reference statements)

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“…Similarly, Lee et al also determined the LOQs as ten times the S/N ratio, and obtained a LOQ for sulfamethazine that was equal to ours (0.5 ng g −1 ), but the one for sulfamethoxazole was lower (0.5 vs. 2.5 ng g −1 ) [33]. Finally, Ferhi et al determined the LOQs with the results of the validation data in a more similar way to ours for diclofenac, sulfamethoxazole, and sulfamethoxazole, our values being lower in the first two cases and slightly higher but in the same range in the latter (2.1 ng g −1 vs. 5 ng g −1 ) [34].…”

Section: In House Validation Studiessupporting

confidence: 68%

An Easy Procedure to Quantify Anticoagulant Rodenticides and Pharmaceutical Active Compounds in Soils

Acosta-Dacal

Rial-Berriel

Díaz-Díaz

et al. 2021

Toxics

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A modified QuEChERS (quick, easy, cheap, effective, rugged, and safe) extraction was validated for the extraction of seven coumarin anticoagulant rodenticides (ARs) and 36 pharmaceutical active compounds (PhACs) residues in soil samples using liquid chromatography tandem mass spectrometry (LC-MS/MS). The aim of this work was to develop a method for the monitoring of these compounds in agricultural lands as well as in forensic applications for the determination of ARs poisoning. As far as is known, this is the first time that a QuEChERS-based method is used for the extraction of ARs in soil, as well as on such a quantity of PhACs. A matrix effect study was carried out on samples of soil devoted to agriculture in the midland area of the Canary Islands (clay loam type). It was in house validated (accuracy, precision, and linearity) at seven spiked levels between 0.5 and 50 ng g−1. The limits of quantification (LOQ) ranged between 0.5 and 50.0 ng g−1 and the limits of detection (LOD) ranged from 0.024 to 6.25 ng g−1. The method was then successfully used for both the determination of the target analytes in the soils from the agricultural plots that had been irrigated with regenerated water, and in the soil collected from underneath wild bird carcasses (which had been the subject of forensic investigation).

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Section: In House Validation Studiessupporting

confidence: 68%

An Easy Procedure to Quantify Anticoagulant Rodenticides and Pharmaceutical Active Compounds in Soils

Acosta-Dacal

Rial-Berriel

Díaz-Díaz

et al. 2021

Toxics

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“…disposal or agricultural application of organic waste products that may contain trace levels of these substances, like manure, wastewater treatment plant effluents, and sewage sludge [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16].…”

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confidence: 99%

Analysis and fate of 14 relevant wastewater-derived organic pollutants in long-term exposed soil

et al. 2019

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The growing use of reclaimed water in agriculture worldwide calls for developing high-sensitivity methods to quantify wastewater-derived organic contaminants in soils so that the potential risk of this irrigation practice can be properly assessed. This work describes an analytical method for the determination of trace levels of 14 drugs that are known to be poorly removed during conventional wastewater treatment in soil. The analytes selected for investigation included ten pharmaceuticals from different therapeutic classes (carbamazepine diclofenac, cis-diltiazem lamotrigine, methadone, midazolam, oxcarbazepine, sulfamethoxazole, trimethoprim, valsartan), one illicit drug (cocaine), and three transformation products/metabolites (acridone, 4′hydroxydiclofenac, and valsartan acid), thereby covering a broad range of physical-chemical properties. The methodology developed was based on ultrasonic solvent extraction (USE) of the analytes from the soil matrix, and subsequent clean-up and analysis of the USE extracts with a fully automated approach by means of solid-phase extraction and liquid chromatographytandem mass spectrometry detection (online SPE-LC-MS/MS). The method was fully validated with affording method detection and quantification limits ranging from 0.03 to 1 ng g −1 and from 0.09 to 3.3 ng g −1 , respectively. This method was applied to investigate the fate of the selected drugs in potting soil irrigated for a long term (60 days) either with water containing the target compounds at a concentration of 200 μg L −1 or with wastewater treatment plant effluent and thus, at real environmental concentrations. All investigated compounds were found to accumulate in soil irrigated with artificially fortified water. The highest accumulation potential was observed for cis-diltiazem followed by methadone and midazolam that presented average concentrations of 1517 ng g −1 , 1041 ng g −1 , and 962 ng g −1 d.w., respectively. On the contrary, oxcarbazepine (5.8 ng g −1) and sulfamethoxazole (22 ng g −1) were the target drugs presenting the lowest accumulation potential. Only trace levels of ten drugs were measured in soil irrigated with regenerated water (average concentrations between 1.6 and 4.7 ng g −1 d.w.).

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“…According to past studies, mixing organic acids (including formic acid [39], phosphate [41], Na 2 EDTA-Mcllvaine [38,42]) with methanol [37] or ACN [43] is the most effective extraction solution with good recovery efficiency and has good reproducibility when analyzing multiple antibiotic residues in environmental matrices. Ferhi et al [34] demonstrated that ACN and citric acid-phosphate buffer can be used to efficiently extract eight antibiotics from the soil. The increase in ionic strength caused by the addition of Na 2 EDTA increases the solubility of the target compound in the organic solvent (ACN) of the extraction medium, thereby improving the extraction efficiency.…”

Section: Choice Of Extractantmentioning

confidence: 99%

“…One method that solves these problems is the QuECh-ERS method. Past studies have applied it to various food substrates such as radishes [25], milk [26], honey [27], vegetables [28][29] and environmental substrates such as plant tissues [30], manure [31], wastewater [32], sludge [33][34], and sediments [35]. At present, the QuEChERS method has been used to extract antibiotics from the soil matrix and most studies focused on the extraction of a single type of antibiotic or a certain number of antibiotics [36][37].…”

Section: Introductionmentioning

confidence: 99%

Determination of multiple antibiotics in agricultural soil using a quick, easy, cheap, effective, rugged, and safe method coupled with ultra‐high performance liquid chromatography‐tandem mass spectrometry

Zhang

Liu³

et al. 2021

J of Separation Science

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In this study, we combined ultra-high performance liquid chromatography with tandem mass spectrometry to establish a quick, easy, cheap, effective, rugged, and safe method of detecting 21 target antibiotics in agricultural soil samples.Antibiotics were extracted with mixed solvents consisting of ethylenediaminetetraacetic acid disodium salt dihydrate and phosphoric acid citric acid buffer and acetonitrile which were purified with octadecylsilyl as an adsorbent and anhydrous sodium sulfate as a desiccant. This method was able to effectively extract all of the target antibiotics from agricultural soils, with recovery efficiencies ranging from 55 to 108% and limits of detection between 0.09-0.68 μg/kg. We also validated this new method for selectivity, sensitivity, and reliability of detecting multiple antibiotics in 12 samples. Considering the potential environmental and public health effects of antibiotics in agricultural soils, our new method can help analyze the degree of antibiotic contamination and provide valuable information for soil quality and risk assessment.

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Factors influencing the extraction of pharmaceuticals from sewage sludge and soil: an experimental design approach

Cited by 39 publications

References 36 publications

An Easy Procedure to Quantify Anticoagulant Rodenticides and Pharmaceutical Active Compounds in Soils

An Easy Procedure to Quantify Anticoagulant Rodenticides and Pharmaceutical Active Compounds in Soils

Analysis and fate of 14 relevant wastewater-derived organic pollutants in long-term exposed soil

Determination of multiple antibiotics in agricultural soil using a quick, easy, cheap, effective, rugged, and safe method coupled with ultra‐high performance liquid chromatography‐tandem mass spectrometry

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