Improved reverse thermo-responsive polymeric systems

Cohn, Daniel; Sosnik, Alejandro; Levy, Avraham A.

doi:10.1016/s0142-9612(03)00245-x

Cited by 163 publications

(128 citation statements)

References 29 publications

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“…The hydrogels show a low viscosity, which has as consequences poor mechanical strength, high permeability and limited stability with quick dissolution [61,62]. Cohn and colleagues proposed two new mechanisms to create copolymers based on Pluronic® F127 with improved mechanical properties.…”

Section: Peo/ppo-based Systemsmentioning

confidence: 99%

“…The second relied on the covalent binding of poly(ethylene glycol) and poly(propylene glycol), which as such do not possess thermogelling properties at physiological temperatures, using phosgene as a coupler and forming poly(ether-carbonates). Both newly synthesized polymers exhibited significantly higher viscosities than F127 at 37°C, and the poly(ether-urethanes) displayed much slower drug release kinetics than the original polymer [61]. The group developed the idea of thermoresponsive PEO/PPO polymers with improved mechanical behavior further in the next years.…”

Section: Peo/ppo-based Systemsmentioning

confidence: 99%

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Thermoresponsive hydrogels in biomedical applications

Klouda

Mikos

2008

European Journal of Pharmaceutics and Biopharmaceutics

1,116

696

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Environmentally responsive hydrogels have the ability to turn from solution to gel when a specific stimulus is applied. Thermoresponsive hydrogels utilize temperature change as the trigger that determines their gelling behavior without any additional external factor. These hydrogels have been interesting for biomedical uses as they can swell in situ under physiological conditions and provide the advantage of convenient administration. The scope of this paper is to review the aqueous polymer solutions that exhibit transition to gel upon temperature change. Typically, aqueous solutions of hydrogels used in biomedical applications are liquid at ambient temperature and gel at physiological temperature. The review focuses mainly on hydrogels based on natural polymers, N-isopropylacrylamide polymers, poly(ethylene oxide)-b-poly(propylene oxide)-bpoly(ethylene oxide) polymers as well as poly(ethylene glycol)-biodegradable polyester copolymers.

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Section: Peo/ppo-based Systemsmentioning

confidence: 99%

Section: Peo/ppo-based Systemsmentioning

confidence: 99%

Thermoresponsive hydrogels in biomedical applications

Klouda

Mikos

2008

European Journal of Pharmaceutics and Biopharmaceutics

1,116

696

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“…51 Kang et al investigated diblock copolymers, where the first block was based on methoxy poly(ethylene glycol) (MPEG) and the second block on both CL and LLA units, randomly distributed. 52 The CL/LLA ratio was varied and only polymers with a high ratio formed gels of which the T gel decreased with increasing CL content.…”

Section: Effect Of Composition/ Hydrophobicitymentioning

confidence: 99%

Tuning the gelation of thermoresponsive gels

Constantinou

Georgiou

2016

European Polymer Journal

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Thermoresponsive gels are exciting polymeric materials with many biomedical applications in medical devices, drug delivery, tissue engineering and bio-printing. Also, they have great potential to be used in 3-D printing and thus in the fabrication of many different devices and materials. As it is crucial for the application of these gels to be able to control and tailor the gelation temperature and concentration this was the main focus and point of discussion of this feature article. Thus, it is discussed in detail how by varying the molar mass, composition, stereochemistry and architecture the thermoresponsive properties of these gels are altered.

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“…Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) block copolymers, which are commercial available amphiphilic polymers as Pluronic and Poloxemer, are widely used as dispersion stabilizers [1,2], pharmaceutical ingredients [3][4][5], biomedical materials [6,7] and templates for the synthesis of mesoporous materials [8][9][10][11] and nanoparticles [12][13][14][15][16][17][18][19]. This is due to a variety of PEO-PPO-PEO block copolymer self-assemblies tuned by molecular characteristics, concentration and temperature in the presence of selective solvents such as water [20,21].…”

Section: Introductionmentioning

confidence: 99%

Vesicle formation in mixture of a PEO-PPO-PEO block copolymer (Pluronic P123) and a nonionic surfactant (Span 65) in water

Sakai

Kurosawa

Okada

et al. 2011

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Fabrication of vesicles with the diameter of 4-30 m was achieved by mixing of a hydrophobic nonionic surfactant (Span 65) with a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer (Pluronic P123) in aqueous solutions at room temperature. Ring-shaped structure of the Pluronic P123/Span 65 mixture assemblies was confirmed by fluorescence microscopy. The presence of internal aqueous phase in the Pluronic P123/Span 65 mixture assemblies was determined by measuring the entrapment efficiency of calcein using fluorescence spectroscopy. On the other hand, Pluronic P123/Span 60 mixture system formed wire-like assemblies but not vesicles.

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Improved reverse thermo-responsive polymeric systems

Cited by 163 publications

References 29 publications

Thermoresponsive hydrogels in biomedical applications

Thermoresponsive hydrogels in biomedical applications

Tuning the gelation of thermoresponsive gels

Vesicle formation in mixture of a PEO-PPO-PEO block copolymer (Pluronic P123) and a nonionic surfactant (Span 65) in water

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