Improved Photoacoustic-Based Oxygen Saturation Estimation With SNR-Regularized Local Fluence Correction

Naser, Mohamed A.; Sampaio, Diego R. T.; Muñoz, Nina M.; Wood, Cayla; Mitcham, Trevor; Stefan, Wolfgang; Sokolov, Konstantin; Pavan, Theo Z.; Avritscher, Rony; Bouchard, Richard R.

doi:10.1109/tmi.2018.2867602

Cited by 27 publications

(19 citation statements)

References 48 publications

(57 reference statements)

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“…Since PA images taken from the human finger joint has shown great potential to evaluate inflammatory arthritis [ 22 , 23 ], it is a possible clinical application where the proposed technique could be beneficial. Future studies will include: (i) evaluating multi-wavelength PA images and fluence correction strategies [ 57 ] to monitor blood oxygen saturation and (ii) evaluate the feasibility of using a high divergent source like LED [ 44 ] to reduce the number of illumination angles.…”

Section: Resultsmentioning

confidence: 99%

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Multiangle Long-Axis Lateral Illumination Photoacoustic Imaging Using Linear Array Transducer

Uliana

Sampaio

Fernandes

et al. 2020

Sensors

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Photoacoustic imaging (PAI) combines optical contrast with ultrasound spatial resolution and can be obtained up to a depth of a few centimeters. Hand-held PAI systems using linear array usually operate in reflection mode using a dark-field illumination scheme, where the optical fiber output is attached to both sides of the elevation plane (short-axis) of the transducer. More recently, bright-field strategies where the optical illumination is coaxial with acoustic detection have been proposed to overcome some limitations of the standard dark-field approach. In this paper, a novel multiangle long-axis lateral illumination is proposed. Monte Carlo simulations were conducted to evaluate light delivery for three different illumination schemes: bright-field, standard dark-field, and long-axis lateral illumination. Long-axis lateral illumination showed remarkable improvement in light delivery for targets with a width smaller than the transducer lateral dimension. A prototype was developed to experimentally demonstrate the feasibility of the proposed approach. In this device, the fiber bundle terminal ends are attached to both sides of the transducer’s long-axis and the illumination angle of each fiber bundle can be independently controlled. The final PA image is obtained by the coherent sum of subframes acquired using different angles. The prototype was experimentally evaluated by taking images from a phantom, a mouse abdomen, forearm, and index finger of a volunteer. The system provided light delivery enhancement taking advantage of the geometry of the target, achieving sufficient signal-to-noise ratio at clinically relevant depths.

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Section: Resultsmentioning

confidence: 99%

“…However, we believe it would be possible to acquire images using a matching layer. For example, this layer could be ultrasound imaging gel (see, for example, [ 57 ]) or a gel pad (see, for example, [ 58 ]). This is a topic of ongoing research and should appear in future publications.…”

Section: Methodsmentioning

confidence: 99%

Multiangle Long-Axis Lateral Illumination Photoacoustic Imaging Using Linear Array Transducer

Uliana

Sampaio

Fernandes

et al. 2020

Sensors

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“…3D PA image data were then manually co-registered with 3D X-ray CT image data to determine whether the hemoglobin signal visible in PA images co-located with the BM cavity. Additionally, a noise threshold was applied to PA images to verify that only pixels with signal-to-noise ratio (SNR) >6 dB were included in analysis [22].…”

Section: Methodsmentioning

confidence: 99%

Photoacoustic-based oxygen saturation assessment of murine femoral bone marrow in a preclinical model of leukemia

et al. 2019

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A variety of hematological diseases manifest in the bone marrow (BM), broadly characterized as BM failure (BMF). BMF can be caused by acute lymphoblastic leukemia (ALL), which results in an expansion of hypoxic regions in the BM. Because of this hypoxic presentation, there is potential for improved characterization of BMF through in vivo assessment of oxygenation in the BM cavity. Photoacoustic (PA) imaging can provide local assessment of intravascular oxygen saturation (SO 2 ), which has been shown to correlate with pimonidazole-assessed hypoxia. This study introduces an optimized PA imaging technique to assess SO 2 within the femoral BM cavity through disease progression in a murine model of ALL. Results show a statistically significant difference with temporal changes in SO 2 (from baseline) between control and diseased cohorts, demonstrating the potential of PA imaging for noninvasive, label-free monitoring of BMF diseases.

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“…Due to hazard limitations placed on the laser dosage deposited in biological tissues, the only currently plausible way to improve the SNR while increasing the speed is through image and signal processing, i.e., so‐called information mining. Various image and signal processing algorithms have been developed in OR‐PAM to improve the image quality, such as image denoising, [ 22,23 ] compressed sensing, [ 24 ] and vascular filtering. [ 25,26 ] While these algorithms have progressively improved the quality of OR‐PAM imaging successfully, the extent of the improvement using image‐based postprocessing methods has been limited.…”

Section: Introductionmentioning

confidence: 99%

Deep Learning Enables Superior Photoacoustic Imaging at Ultralow Laser Dosages

Zhao

Yang

et al. 2020

Advanced Science

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Optical‐resolution photoacoustic microscopy (OR‐PAM) is an excellent modality for in vivo biomedical imaging as it noninvasively provides high‐resolution morphologic and functional information without the need for exogenous contrast agents. However, the high excitation laser dosage, limited imaging speed, and imperfect image quality still hinder the use of OR‐PAM in clinical applications. The laser dosage, imaging speed, and image quality are mutually restrained by each other, and thus far, no methods have been proposed to resolve this challenge. Here, a deep learning method called the multitask residual dense network is proposed to overcome this challenge. This method utilizes an innovative strategy of integrating multisupervised learning, dual‐channel sample collection, and a reasonable weight distribution. The proposed deep learning method is combined with an application‐targeted modified OR‐PAM system. Superior images under ultralow laser dosage (32‐fold reduced dosage) are obtained for the first time in this study. Using this new technique, a high‐quality, high‐speed OR‐PAM system that meets clinical requirements is now conceivable.

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Improved Photoacoustic-Based Oxygen Saturation Estimation With SNR-Regularized Local Fluence Correction

Cited by 27 publications

References 48 publications

Multiangle Long-Axis Lateral Illumination Photoacoustic Imaging Using Linear Array Transducer

Multiangle Long-Axis Lateral Illumination Photoacoustic Imaging Using Linear Array Transducer

Photoacoustic-based oxygen saturation assessment of murine femoral bone marrow in a preclinical model of leukemia

Deep Learning Enables Superior Photoacoustic Imaging at Ultralow Laser Dosages

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