Improved Performance of a Tandem Quadrupole/Time-of-Flight Mass Spectrometer

Glish, Gary L.; McLuckey, Scott A.; McKown, H.S.

doi:10.1080/10739148708543635

Cited by 22 publications

(4 citation statements)

References 5 publications

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“…The ion source has been evaluated with a tandem mass spectrometer constructed at Oak Ridge (28). Briefly, the instrument consists of a quadrupole mass filter (Extrel C50 system) as the first stage mass analyzer followed by a time-of-flight mass spectrometer.…”

Section: Discussionmentioning

confidence: 99%

Atmospheric sampling glow discharge ionization source for the determination of trace organic compounds in ambient air

Glish²,

et al. 1988

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Section: Discussionmentioning

confidence: 99%

Atmospheric sampling glow discharge ionization source for the determination of trace organic compounds in ambient air

Glish²,

et al. 1988

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“…Tandem Magnetic Sector/Time-of-Flight Analyzers. The exploitation of the unique properties of the TOF analyzer in hybrid MS/MS instruments has employed precursor ion analysis using quadrupoles by Glish et al (C72,C73), a Wien filter (C74), or a double-focusing magnetic instrument (C75, C76). All of these designs utilized an in-line arrangement, so that the fragment ions presented to the TOF stage possessed wide spreads of transla- tional energy arising from the kinetic energy release amplified in the laboratory reference frame.…”

Section: Innovative Techniques and Instrumentationmentioning

confidence: 99%

Mass Spectrometry

1996

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B27) in honor of Fred McLafferty. By its nature, Rapid Communications in Mass Spectrometry does not publish many review articles, but Lammert's annual updates of the Directory of Mass Spectrometry Manufacturers and Suppliers (B28, B29) are extremely useful. In addition, this journal periodically publishes a group of papers exemplifying the work of well-known centers for mass spectrometry around the world. A new journal, European Mass Spectrometry, commenced publication in 1995 (B30). The A-pages of Analytical Chemistry continue to feature brief review articles of interest to mass spectrometrists. On-line coupling of mass spectrometers to high-resolution separation techniques was covered exhaustively in the 1994 edition of the present review, and here we draw attention only to two recent special issues of the Journal of Chromatography A, one dealing with hyphenated and coupled-column techniques (B31) and one containing papers from the 11th Montreux Symposium on liquid chromatographymass spectrometry and related techniques (B32).Recent books and monographs relevant to the present review, and not mentioned in the 1994 edition, include Laser Ionization Mass Analysis edited by Vertes, Gijbels, and Adams (B33), Applications of Mass Spectrometry to Organic Stereochemistry edited by Turecek (B34), Forensic Applications of Mass Spectrometry edited by Yinon (B35), Experimental Mass Spectrometry edited by Russell (B36),

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“…Other limitations of the approach, related to conducting CID at keV collision energies, included low MS/MS efficiency, a wide spread of kinetic energies for the product ions that made ion optics design quite challenging, and the amplification of kinetic energy release [51]. To address the issues associated with high-energy CID, a group at Oak Ridge National Laboratory combined a quadrupole mass filter with a TOF analyzer (Q/TOF) [52,53]. This combination of analyzers took advantage of the higher MS/MS efficiency demonstrated for triple quadrupole instruments with the analysis speed and sensitivity of a TOF analyzer.…”

Section: Beam-beam Hybrid Instrumentsmentioning

confidence: 99%

Hybrid mass spectrometers for tandem mass spectrometry

Glish

Burinsky

2008

J. Am. Soc. Mass Spectrom.

103

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Mass spectrometers that use different types of analyzers for the first and second stages of mass analysis in tandem mass spectrometry (MS/MS) experiments are often referred to as "hybrid" mass spectrometers. The general goal in the design of a hybrid instrument is to combine different performance characteristics offered by various types of analyzers into one mass spectrometer. These performance characteristics may include mass resolving power, the ion kinetic energy for collision-induced dissociation, and speed of analysis. This paper provides a review of the development of hybrid instruments over the last 30 years for analytical applications. (J Am Soc Mass Spectrom 2008, 19, 161-172) © 2008 American Society for Mass Spectrometry T andem mass spectrometry (MS/MS), in a very generic description, is a process in which an ion formed in an ion source is mass-selected in the first stage of analysis, reacted, and then the charged products from the reaction are analyzed in the second stage of analysis. The type and quality of data that is obtained can vary greatly depending upon the type of analyzer used in the first and second stages of analysis, and the type of reaction performed between the stages of analysis. The reactions that can be done also can depend upon the type of analyzer. Over the years there have been a variety of means developed to measure the mass-to-charge ratio of gas-phase ions. The most common methods involve: dispersion based on ion momentum or kinetic energy (magnetic and electric sector instruments); separation in time based on ion velocity (time-of-flight); transmission through an electrodynamic field (quadrupole mass filter); and periodic motion in a magnetic or electrodynamic field (ion traps). There are differences in the experimental parameters associated with these various analysis methods that are pertinent to the MS/MS experiment. Some parameters are obvious, typically related to the performance of the mass analyzer while others are more subtle, related to the reactions/chemistry occurring between the stages of analysis. Many times these different parameters are used to categorize MS/MS experiments.One parameter is the ion kinetic energy. Sector and time-of-flight (TOF) instruments typically operate at "high" ion kinetic energies (5-20 keV), whereas "low" ion kinetic energies (Ͻ50 eV) are typical in quadrupole mass filters and ion traps. The ion kinetic energy is an important parameter in MS/MS experiments because the most common reaction involves colliding the ion of interest with a target gas atom or molecule. When performing ion-neutral collision experiments, the possible reactions that can be accessed (e.g., collisioninduced dissociation, collisional cooling, charge permutation, ion/molecule reaction) depends upon the ion kinetic energy. The appearance of the MS/MS spectrum can change drastically as a function of the collision (ion kinetic) energy. A related factor that is equally important, but often not considered, is the time frame of the experiment, that is, the elapsed time bet...

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Improved Performance of a Tandem Quadrupole/Time-of-Flight Mass Spectrometer

Cited by 22 publications

References 5 publications

Atmospheric sampling glow discharge ionization source for the determination of trace organic compounds in ambient air

Atmospheric sampling glow discharge ionization source for the determination of trace organic compounds in ambient air

Mass Spectrometry

Hybrid mass spectrometers for tandem mass spectrometry

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