Improved oral bioavailability of the hypocholesterolemic DMP 565 in dogs following oral dosing in oil and glycol solutions

Microencapsulation of self-microemulsifying system: Improving solubility and permeability of furosemide

“…According to the literature data, there is a growing interest in the lipid-and surfactant-based systems e.g. lipid solution, surfactant dispersion emulsion, liposomes, microemulsion, dry emulsion and self-(micro)emulsifying formulations (Shah et al, 1994;Burcham et al, 1997;Šentjurc et al, 1999;Jumaa et al, 2002;Neslihan and Benita, 2004;Porter et al, 2007;Patil et al, 2007).…”

Enhanced Oral Bioavailability of Daidzein by Self-Microemulsifying Drug Delivery System

“…Several approaches such as absorption enhancers, 1,2) chemical modification 3,4) and dosage forms 5,6) have been explored in order to attain peroral delivery of drugs. Lipid-based formulations such as drug incorporation into oils, 7) emulsions 8) and in particular self-microemulsifying formulations 9,10) are known to be successful. Self-microemulsifying drug delivery system (SMEDDS) are defined as isotropic mixtures of oil, surfactant, co-surfactant and drug that rapidly form a microemulsion upon mixing with water.…”

Nanoemulsions in Medicine

“…65,66 Together, dispersion of the lipophilic species, within a NE formulation, and protection of in vivo degradation enhances the bioavailability of dispersed therapeutics. 67 In terms of orally delivered NEs, enhanced bioavailability has also been observed but it is not yet clearly understood; several different potential mechanisms have been proposed in the literature. [68][69][70][71][72] Furthermore, the use of NEs limits the exposure of gut-wall tissue 73 or epithelial cells 3 -depending on the route of administration -to the dispersed therapeutics, thus reducing irritation.…”