Improved mechanical properties of polyacrylamide hydrogels created in the presence of low-molecular-weight hydrogelators

Ohsedo, Yutaka; Taniguchi, Makiko; Saruhashi, Kowichiro; Watanabe, Hisayuki

doi:10.1039/c5ra16823f

Cited by 14 publications

(8 citation statements)

References 56 publications

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“…In general, PAMbased IPN-structured hydrogels are robust and capable of withstanding highly compressive stress without breakage. 27 In the present study, the PDA−SA−PAM adhesive hydrogels appeared to be stretchable and robust. Moreover, the SA− PAM and 0.4PDA−SA−PAM hydrogels can rapidly return to the original shape after the application of a compression force (Supporting Information Figure S5).…”

Section: ■ Introductionsupporting

confidence: 47%

Mussel-Inspired Cell/Tissue-Adhesive, Hemostatic Hydrogels for Tissue Engineering Applications

2019

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The combination of multiple physiological (swelling, porosity, mechanical, and biodegradation) and biological (cell/tissue-adhesive, cell proliferation, and hemostatic) properties on a single hydrogel has great potential for skin tissue engineering. Adhesive hydrogels based on polydopamine (PDA) have become the most popular in the biomedical field; however, integrating multiple properties on a single adhesive hydrogel remains a challenge. Here, inspired by the chemistry of mussels, we developed PDA–sodium alginate–polyacrylamide (PDA–SA–PAM)-based hydrogels with multiple physiological and biological properties for skin tissue engineering applications. The hydrogels were prepared by alkali-induced polymerization of DA followed by complexation with SA in PAM networks. The chemical composition of the hydrogels was characterized by X-ray photoelectron spectroscopy. PDA–SA complexed chains were homogeneously dispersed in the PAM network and exhibited good elasticity and excellent mechanical properties, such as a compressive stress of 0.24 MPa at a compression strain of 70% for 0.4PDA–SA–PAM. The adhesive hydrogel also maintained a highly interconnected porous structure (∼94% porosity) along with PDA microfibrils. The hydrogel possesses outstanding swelling and biodegradability properties. Owing to the presence of the PDA–SA complex in the PAM network, the hydrogels show good adhesion to various substrates (plastic, skin, glass, computer screens, and leaves); for example, the adhesive strength of the 0.4PDA–SA–PAM to porcine skin was 24.5 kPa. The adhesive component of the PDA–SA chains in the PAM network significantly improves the cell proliferation, cell attachment, cell spreading, and functional expression of human skin fibroblasts (CCD-986sk) and keratinocytes. Moreover, the PDA chains exhibited good hemostatic properties, resulting in rapid blood coagulation. Considering their excellent cell affinity, and rapid blood coagulation ability, these mussel-inspired hydrogels have substantial potential for skin tissue engineering applications.

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Section: ■ Introductionsupporting

confidence: 47%

Mussel-Inspired Cell/Tissue-Adhesive, Hemostatic Hydrogels for Tissue Engineering Applications

2019

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“…On the other hand, B x SP‐PANI based hydrogel are robust and fully capable of withstanding a large degree of compressive deformation without rupture (Figure 2d). [ 37 ] Under 80% strain test, the compressive stress of the BSP‐PANI hydrogels is superior to the corresponding hydrogels devoid of PANI network, suggesting the H‐bonds exist between the PANI and BSP. This is also demonstrated in Figure S3, Supporting Information, where the sample immersed in urea solution releases more PANI and the solution becomes darker in the same time.…”

Section: Resultsmentioning

confidence: 99%

Bacterial Cellulose Reinforced Polyaniline Electroconductive Hydrogel with Multiple Weak H‐Bonds as Flexible and Sensitive Strain Sensor

Qin

Chen

Huang

et al. 2021

Macro Materials & Eng

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Hydrogel, as a promising soft material, possesses many functional advantages such as stretchability, viscoelasticity, and biocompatibility. An advanced electronic platform for strain sensor is constructed by modifying hydrogels with various doping techniques. Herein, a novel flexible conductive hydrogel is synthesized by combination of bacterial cellulose/sodium alginate/polyacrylamide with the polyaniline (BSP‐PANI) through multiple intermolecular interactions. In the obtained BSP‐PANI hydrogel system, the incorporated BC serves the function of mechanically toughening and the formation of polyaniline conducting network endows the hydrogels electrical conductivity. The assembled hydrogel strain sensor can detect electrical response under different applied strains (1–200%) and monitor human motion in real time. Therefore, it is believed that the BSP‐PANI hydrogel prepared by the feasible synergetic strategy proposed in this work has greatly diversified application in smart epidermal sensors and artificial intelligence devices.

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“…It is expected that Laponite should form a small network in an aqueous solution at a lower concentration that is insufficient for the formation of a gel. During the gelation of the composite, the homogeneity of the Laponite network may increase the homogeneity of the NaPPDT network in the composite gel; this may in turn enhance the mechanical properties of the composite gel, as shown by the polymer gel system [ 83 ]. Thus, it is speculated that an increase in the number of effective hydrogen bonds between NaPPDT chains and an increase in the homogeneity of the NaPPDT network in the composite gel may play crucial roles in facilitating thixotropic behaviour.…”

Section: Resultsmentioning

confidence: 99%

New composite thixotropic hydrogel composed of a polymer hydrogelator and a nanosheet

et al. 2017

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A composite gel composed of a water-soluble aromatic polyamide hydrogelator and the nanosheet Laponite®, a synthetic layered silicate, was produced and found to exhibit thixotropic behaviour. Whereas the composite gel contains the gelator at the same concentration as the molecular gel made by the gelator only, the composite gel becomes a softer thixotropic gel compared to the molecular gel made by the gelator only. The reason for this could be that bundles of polymer gelator may be loosened and the density of the polymer network increased in the presence of Laponite.

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Improved mechanical properties of polyacrylamide hydrogels created in the presence of low-molecular-weight hydrogelators

Abstract: It was found that the crushing stress of the obtained polyacrylamide hydrogels was enhanced by using the molecular gel as removable templates.

Cited by 14 publications

References 56 publications

Mussel-Inspired Cell/Tissue-Adhesive, Hemostatic Hydrogels for Tissue Engineering Applications

Mussel-Inspired Cell/Tissue-Adhesive, Hemostatic Hydrogels for Tissue Engineering Applications

Bacterial Cellulose Reinforced Polyaniline Electroconductive Hydrogel with Multiple Weak H‐Bonds as Flexible and Sensitive Strain Sensor

New composite thixotropic hydrogel composed of a polymer hydrogelator and a nanosheet

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