Improved measurement of iodine in food samples using inductively coupled plasma isotope dilution mass spectrometry

Haldimann, Max; Eastgate, Alan; Zimmerli, B.

doi:10.1039/b005879n

Cited by 69 publications

(60 citation statements)

References 29 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For ICP-MS, the signals are just slightly enhanced with respect to a double pass spray chamber and the wash out times found with the Cinnabar are significantly shortened [138]. Due to its simplicity and the small dispersion arising with this spray chamber, it has been successfully applied as a CE-ICP-MS interface [139].…”

Section: Low Inner Volume Cyclonic Spray Chambermentioning

confidence: 99%

Sample introduction systems for the analysis of liquid microsamples by ICP-AES and ICP-MS

Todolı́

Mermet²

2006

Spectrochimica Acta Part B: Atomic Spectroscopy

131

View full text Add to dashboard Cite

show abstract

Section: Low Inner Volume Cyclonic Spray Chambermentioning

confidence: 99%

Sample introduction systems for the analysis of liquid microsamples by ICP-AES and ICP-MS

Todolı́

Mermet²

2006

Spectrochimica Acta Part B: Atomic Spectroscopy

131

View full text Add to dashboard Cite

show abstract

“…ICP-MS allows direct determination of iodine in urine. Application of isotope dilution analysis using I 129 as a spike as well as the instrumental design permit automatic, accurate and reproducible measurements (Haldimann et al, 1998(Haldimann et al, , 2000. In order to conform with the international scientific literature on the matter, results were expressed as mg I=l urine and as mg I=g creatinine.…”

Section: Laboratory Analysesmentioning

confidence: 99%

Swiss pilot study of individual seasonal fluctuations of urinary iodine concentration over two years: is age-dependency linked to the major source of dietary iodine?

et al. 2003

View full text Add to dashboard Cite

Objective: Because of known significant seasonal fluctuations of iodine concentration in cow's milk (ICM) in Switzerland (winter=summer (w=s) ICM ratio averages 5.6), we looked for seasonal variations and familial aspects in urinary iodine and sodium concentrations (UIC, UNaC). Design: Prospective sequential cohort investigation. Setting: University hospital. Subjects: Thirteen children (six girls, seven boys) aged 3 -10 y and their parents (n ¼ 9) aged 30 -47 y. Interventions: The volunteers collected 1729 spot urine samples (5.1996 -5.1998). UIC data from winter (UIC w : DecemberFebruary) and summer seasons (UIC s : July -September) were compared with UNaC and average milk consumption. Iodine intakes from milk and salt were modelized. Results: Highest seasonal fluctuations of UIC were found in six pre-school children (w=s UIC group average ¼ 1.56, significant), followed by seven school children (w=s UIC group average ¼ 1.24, N.S.); none existed in adults. UIC=UNaC showed corresponding seasonal fluctuations in children, but not in adults. Winter milk was an important iodine source for children, as proven indirectly by similar seasonal fluctuations of ICM, UIC, UIC=UNaC and an important part within UIC due to milk. Conclusions: Contribution to UIC from milk intake during winter was high in children (40 -50%) and lower in adults (about 20%). Compared with children, dietary habits of adults are more complex and their iodine supply depends mainly on iodized salt and not on milk, so the effect of seasonal ICM variations on UIC is less marked. Because of significant seasonal UIC fluctuations in consumers of fresh milk products in Switzerland, results of future UIC studies conducted during summer and winter seasons should be compared cautiously, especially in young children. Furthermore, consumption of milk is to be promoted, since, besides calcium and vitamins, it is an essential source of iodine. UNaC determination should be included in epidemiologic studies if the dietary source of iodine is questioned. Sponsorship: This work was supported by grants from the University Hospital in Bern, the Swiss Federal Office of Public Health, the 'Swiss National Foundation for Scientific Research' (32-49424.96), the 'Fondation Genevoise de Bienfaisance V Rossi di Montelera', the 'Schweizerische Lebensversicherungs-und Rentenanstalt' and the 'Schüpbach Foundation of the University of Bern'. European Journal of Clinical Nutrition (2003) 57, 636 -646. doi:10.1038=sj.ejcn.1601590 Keywords: iodine; season; milk; child; diet; salt *Correspondence: C Als, Division of Clinical Chemistry, Inselspital, University of Bern, CH-3010 Bern, Switzerland. E-mail: claudine.als@insel.ch Guarantors: C Als, B Zimmerli and M Haldimann. Contributors: CA had the initial idea, wrote and coordinated the project over several years. CA and BZ wrote the manuscript. MH and BZ did the calculations and the statistical evaluations. MH did the analyses of urinary iodine in his laboratory. All contributors helped in planning the study, evaluating the results a...

show abstract

“…One study found differences in BMIC between fore-and hind-milk samples (17) while another did not (18). Broad ranges of BMIC have been reported in iodine-sufficient countries (9)(10)(11)19), but comparing BMIC across studies is difficult because of differences in study design, analytical methods, and the lack of external quality control (9,17,(20)(21)(22)(23)(24).…”

mentioning

confidence: 99%

Optimization of a New Mass Spectrometry Method for Measurement of Breast Milk Iodine Concentrations and an Assessment of the Effect of Analytic Method and Timing of Within-Feed Sample Collection on Breast Milk Iodine Concentrations

Dold

Baumgartner

Zeder

et al. 2016

Thyroid

Self Cite

View full text Add to dashboard Cite

Background: Breast milk iodine concentration (BMIC) may be an indicator of iodine status during lactation, but there are few data comparing different analytical methods or timing of sampling. The aims of this study were: (i) to optimize a new inductively coupled plasma mass spectrometry (ICP-MS) method; and (ii) to evaluate the effect of analytical method and timing of within-feed sample collection on BMIC. Methods: The colorimetric Sandell-Kolthoff method was evaluated with (a) or without (b) alkaline ashing, and ICP-MS was evaluated using a new 129 I isotope ratio approach including Tellurium (Te) for mass bias correction (c) or external standard curve (d). From iodine-sufficient lactating women (n = 97), three samples were collected within one breast-feeding session (fore-, mid-, and hind-feed samples) and BMIC was analyzed using (c) and (d). Results: Iodine recovery from NIST SRM1549a whole milk powder for methods (a)-(d) was 67%, 24%, 105%, and 102%, respectively. Intra-and inter-assay coefficients of variation for ICP-MS comparing (c) and (d) were 1.3% versus 5.6% ( p = 0.04) and 1.1% versus 2.4% ( p = 0.33). The limit of detection (LOD) was lower for (c) (0.26 lg/kg) than it was for (d) (2.54 lg/kg; p = 0.02). Using (c), the median [95% confidence interval (CI) obtained by bootstrap] BMIC (lg/kg) in foremilk (179 ) and in mid-feed milk (184 [CI 160-220]) were not significantly different ( p = 0.017), but were higher than in hindmilk (175 ; p < 0.001). In foremilk using (d), ; p < 0.001 vs. (c)). The variation in BMIC comparing (c) and (d) (13%) was greater than variation within feeding (5%; p < 0.001). Conclusions: Because of poor recoveries, (a) and (b) should not be used to measure BMIC. Compared with (d), (c) has the advantages of higher precision and a lower LOD. In iodine-sufficient women, BMIC shows low variation within a breast-feeding session, so timing of sampling is not a major determinant of BMIC.

show abstract

Improved measurement of iodine in food samples using inductively coupled plasma isotope dilution mass spectrometry

Cited by 69 publications

References 29 publications

Sample introduction systems for the analysis of liquid microsamples by ICP-AES and ICP-MS

Sample introduction systems for the analysis of liquid microsamples by ICP-AES and ICP-MS

Swiss pilot study of individual seasonal fluctuations of urinary iodine concentration over two years: is age-dependency linked to the major source of dietary iodine?

Optimization of a New Mass Spectrometry Method for Measurement of Breast Milk Iodine Concentrations and an Assessment of the Effect of Analytic Method and Timing of Within-Feed Sample Collection on Breast Milk Iodine Concentrations

Contact Info

Product

Resources

About