Improved Management of Abdominal Undescended Testicular Tumors with Bulky Confluent Retroperitoneal Nodal Metastases

Kulkarni, Jagdeesh N.; Desai, Samir M.; Phadke, Girish K.; Tongaonkar, Hemant

doi:10.1016/s0022-5347(01)65582-4

Cited by 10 publications

(3 citation statements)

References 14 publications

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“…These tumours usually require initial chemotherapy followed by surgical removal of the primary and the residual metastasis. Atypically altered ilioinguinal metastases may necessitate changing radiotherapy ports RPLND boundaries [ 9 ]. The advanced-stage at presentation of testicular cancers in undescended testis has also been demonstrated by Saini et al [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

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Management of testicular tumours in patients with undescended testes – a challenging but rewarding task: experience from a tertiary care cancer centre in India

Tongaonkar¹,

Simha²,

Menon³

et al. 2023

ecancer

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Objective: Primary objective: To study patients' clinical profile and outcomes with germ cell tumours developing in undescended testes. Materials and methods:Case records of patients enlisted in the prospectively maintained 'testicular cancer database' at our tertiary cancer care hospital from 2014 to 2019 were retrospectively reviewed. Any patient who presented with testicular germ cell tumour with a documented history/diagnosis of undescended testes, whether surgically corrected or not, was considered for this study. The patients were managed along the standard lines of treatment for testicular cancer. We evaluated clinical features, difficulties and delays in diagnosis and complexities in management. We evaluated event-free survival (EFS) and overall survival (OS) using the Kaplan-Meier Method. a median follow-up of 66 months (95% CI: 51-76), there were four relapses (all NSGCT) and one death. The 5-year EFS was 90.7% (95% CI: 82.9-98.7). The 5-year OS was 96.3% (95% CI: 91.2-100) Conclusions:The tumours in undescended testes, particularly those without prior orchiopexy, often presented late and with bulky masses, requiring complex multidisciplinary management. Despite the complexity and challenges, our patient's OS and EFS matched that of patients with tumours in normally descended testes. Orchiopexy may help in earlier detection. In the first such series from India, we show that testicular tumours in the cryptorchid are also as curable as the germ cell tumours developing in the descended testis.A multidisciplinary disease management group with expertise in managing complex cases is crucial for a favourable outcome in these groups of patients. We also found that orchiopexy done even later in life confers an advantage in terms of early detection in a subsequently developing testicular tumour .

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Section: Discussionmentioning

confidence: 99%

“…The challenges in managing testicular cancer in cryptorchid testis, presenting directly with cancer, have been sparsely described in the literature [7][8][9], especially those in an intra-abdominal or pelvic location.…”

Section: Introductionmentioning

confidence: 99%

Management of testicular tumours in patients with undescended testes – a challenging but rewarding task: experience from a tertiary care cancer centre in India

Tongaonkar¹,

Simha²,

Menon³

et al. 2023

ecancer

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“…The first line treatment in this case was based on BEP chemotherapy, since the surgical removal of the primary intra-abdominal undescended testis with bulky retroperitoneal metastasis was considered to be technically hazardous. The chemotherapy was followed by removal of the primary tumor and residual tissues once tumor markers normalized after the first line chemotherapy [14]. Histopathological study failed to show any viable tumor neither in the testis nor in the residual masses, but only necrosis.…”

Section: Discussionmentioning

confidence: 99%

Complete Remission by Primary Chemotherapy of Advanced Non-Seminomatous Germ Cell Tumor in an Intra-Abdominal Testis

Sarkis¹,

Kourié²,

Gharios³

et al. 2014

OJU

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Ectopic testis predisposes to a high risk of germ cell tumor development. Treatment of advanced testicular germ cell tumor developing in an uncorrected abdominal testis is based on primary chemotherapy followed by removal of the testis along with residual masses. However, persistence of viable tumor particularly in the testis is always noted since testis penetration of chemotherapeutic agents is reduced. We report a case of complete pathological remission of a patient with advanced non-seminomatous germ cell tumor in intra-abdominal testis by primary chemotherapy alone, with a review of the literature.

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Malignancy in an Undescended Intra-abdominal Testis: a Single Institution Experience

Gupta

Giridhar

Sharma

et al. 2021

Indian J Surg Oncol

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Improved Management of Abdominal Undescended Testicular Tumors with Bulky Confluent Retroperitoneal Nodal Metastases

Cited by 10 publications

References 14 publications

Management of testicular tumours in patients with undescended testes – a challenging but rewarding task: experience from a tertiary care cancer centre in India

Management of testicular tumours in patients with undescended testes – a challenging but rewarding task: experience from a tertiary care cancer centre in India

Complete Remission by Primary Chemotherapy of Advanced Non-Seminomatous Germ Cell Tumor in an Intra-Abdominal Testis

Malignancy in an Undescended Intra-abdominal Testis: a Single Institution Experience

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