Improved hemodialysis with hemocompatible polyethersulfone hollow fiber membranes: <i>In vitro</i> performance

Verma, Surendra Kumar; Modi, Akshay; Singh, Akriti; Teotia, Rohit; Bellare, Jayesh

doi:10.1002/jbm.b.33941

Cited by 37 publications

(19 citation statements)

References 35 publications

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“…Haemolysis refers to the lysis of RBCs when the human blood comes in contact with a membrane material. Therefore, it is desirable to have haemolysis value within the permissible haemolytic limit, which is 5% as prescribed by the ASTM F‐756‐08 standard (Modi et al, 2018c; Verma, Modi, Singh, Teotia, & Bellare, 2018). In this study, the developed materials showed the haemolysis value <5%, that is, within the prescribed limit, which indicated that these HFMs are suitable for blood‐contacting applications (Figure 9a) (Padalhin et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

Hollow fibre membrane bioreactor functionalized with GO‐cryogel 3D matrix promotes liver cell anchoring and their functional maintenance

2020

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The extracorporeal bioartificial liver (BAL) support system with hepatocytes is one of the promising therapeutic approaches for acute liver failure patients to assist in the liver transplantation or facilitate the liver to regenerate (Zhang et al., 2014). The main features to improve the BAL include cell source, sustaining hepatocytes functions and efficient bioreactor design. Scarcity of human liver cells and their restricted ability to proliferate in vitro attract a better cell culture environment that can improve the primary cell expansion, immortalized cell lines or stem cell differentiation of stem cells. Thus, the combined features of the hepatocytes microenvironment and the design of the bioreactor can result in efficacious and scalable liver-centric functions (Allen & Bhatia, 2002). In tissue engineering, a three-dimensional (3D) matrix maintaining functional cells is a potential in vitro biomimetic system. In vitro system is preferred over in vivo models because it offers several advantages, which include evaluation of toxicity mechanism, analysis of drug response relationship, requires a minimal amount of a drug for accessible and direct screening, less expensive and time-saving.Immunoisolation is also an important aspect of BAL. There are different ways of immunoisolation, each offering its advantages

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Section: Resultsmentioning

confidence: 99%

Hollow fibre membrane bioreactor functionalized with GO‐cryogel 3D matrix promotes liver cell anchoring and their functional maintenance

2020

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“…The resulting membrane showed good biocompatibility, but poor UF coefficient (Dahe et al, 2011). Verma at al. (2017) used vitamin E (D-α-Tocopherol polyethylene glycol succinate) (TPGS) and nanozeolite (NZ) to improve the biocompatibility of PES HF membranes.…”

Section: Optimization Of Pesmentioning

confidence: 99%

Advanced Materials for Polymeric Ultrafiltration Membranes Fabrication and Modification

Muhamad¹,

Nazri²,

Lau³

et al. 2018

Advanced Materials for Membrane Fabrication and Modification

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This book contains information obtained from authentic and highly regarded sources. Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. The authors and publishers have attempted to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. If any copyright material has not been acknowledged please write and let us know so we may rectify in any future reprint.Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers.

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“…In addition, the adsorption of naturally existing hydrophobic proteins such as albumin on the membrane surface also causes protein loss. Alternatively, enhancement of membrane permeability and surface hydrophilicity is a viable strategy to improve convective separation of middle molecule uremic toxins and minimize the interaction between membrane surface and hydrophobic proteins …”

Section: Introductionmentioning

confidence: 99%

“…Alternatively, enhancement of membrane permeability and surface hydrophilicity is a viable strategy to improve convective separation of middle molecule uremic toxins and minimize the interaction between membrane surface and hydrophobic proteins. 11,12 Therefore, modifications are needed to achieve excellent membrane separation performance with minimal adverse effects. Incorporation of inorganic nanomaterials in membrane matrices has become an emerging trend to enhance the membrane permeability, selectivity, and physicochemical properties against chemical degradation and thermal instability.…”

Section: Introductionmentioning

confidence: 99%

Iron oxide nanoparticles improved biocompatibility and removal of middle molecule uremic toxin of polysulfone hollow fiber membranes

Said

Abidin

Hasbullah

et al. 2019

J of Applied Polymer Sci

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Middle molecule uremic toxins constitute to a quarter of uremic toxins present in human blood. In a condition where these uremic toxins accumulate in bloodstream due to renal failure, blood purification process using a high performance membrane is required. Here, we develop biocompatible mixed matrix membranes (MMMs) made up of polysulfone (PSf) and iron oxide nanoparticles (Fe2O3 NPs) with the focus to remove middle molecule uremic toxin effectively. The MMMs were evaluated in terms of their biocompatibility and separation performance. At higher Fe2O3 NPs loading, the MMM displayed a huge reduction of protein adsorption and platelet adhesion while maintaining normal blood coagulation time and acceptable complement activation. The optimized MMM exhibited high permeability (110.47 L m−2 h−1 bar−1), protein retention (99.9%) and demonstrated excellent clearance of urea (82%) and lysozyme (46.7%). The PSf/Fe2O3 MMM is proven to have promising attributes for hemodialysis application. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48234.

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Improved hemodialysis with hemocompatible polyethersulfone hollow fiber membranes: In vitro performance

Cited by 37 publications

References 35 publications

Hollow fibre membrane bioreactor functionalized with GO‐cryogel 3D matrix promotes liver cell anchoring and their functional maintenance

Hollow fibre membrane bioreactor functionalized with GO‐cryogel 3D matrix promotes liver cell anchoring and their functional maintenance

Advanced Materials for Polymeric Ultrafiltration Membranes Fabrication and Modification

Iron oxide nanoparticles improved biocompatibility and removal of middle molecule uremic toxin of polysulfone hollow fiber membranes

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