Improved flowability and compactibility of spherically agglomerated crystals of ascorbic acid for direct tableting designed by spherical crystallization process

Kawashima, Yasunaru; Imai, Misato; Takeuchi, Hirofumi; Yamamoto, Hiromitsu; Kamiya, Kazunori; Hino, Tomoaki

doi:10.1016/s0032-5910(02)00206-1

Cited by 123 publications

(84 citation statements)

References 5 publications

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“…This imparted good densification and easy compaction to the material [45,54]. Thus, Heckel plot data suggested that, treated crystals were fractured easily and new surface of crystals produced might contributed to higher plastic deformation under applied compression pressure [53,55]. As described in Fig.…”

Section: Compressibility Studymentioning

confidence: 98%

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Role of excipients in the crystallization of Albendazole

Raval¹,

Vaghela²,

Vachhani³

et al. 2015

Advanced Powder Technology

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Section: Compressibility Studymentioning

confidence: 98%

“…The constants of Heckel plot of pure drug, control batch and treated crystals evaluated are shown in Table 3. Larger value of slop of Heckel plot 'K' was an indication of plastic deformation in the material [53]. Table 3 shows parameters of Heckel plot.…”

Section: Compressibility Studymentioning

confidence: 99%

Role of excipients in the crystallization of Albendazole

Raval¹,

Vaghela²,

Vachhani³

et al. 2015

Advanced Powder Technology

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“…The improved compactibility of agglomerates might be attributed to a characteristic structure responsible for the large relative volume changes during the early stage of the compression process due to their fragmentation. Elastic recovery studies have suggested that agglomerated crystals are easily fractured, and the new surface of crystals produced might contribute to promote plastic deformation under compression [19]. The lower D b value of the agglomerate with PVP compared to the other agglomerates may be attributed to its small particle size.…”

Section: Compaction Behaviormentioning

confidence: 99%

Effect of Additives on the Physicochemical and Drug Release Properties of Pioglitazone Hydrochloride Spherical Agglomerates

Patil¹,

Pawar²,

Kumar³

2012

Trop. J. Pharm Res

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“…Figure 3: Morishima vessel [15] The end point of the process can be determined by the clarity of the supernatant and vaporization of organic solvent from the agglomeration system.…”

Section: Alternate Methodsmentioning

confidence: 99%

Crystallo – Co - Agglomeration: An Innovative Technique for Size Enlargement and Improved Flow Properties of Powders

Enlargement¹

2016

Res. Rev. J Mat. Sci

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Direct compression is the preferred method for tablet manufacturing due to the simplicity in processing and its cost effectiveness. However, for applying direct compression in tablet manufacturing, the drug used should have good flow properties and compaction characteristics. Many drugs are lacking these properties and so it is not possible to compress them directly into tablets. Crystallo co agglomeration (CCA) is an innovative technique developed with intends to provide the drugs with good micromeritic and mechanical characteristics. The process of CCA involves crystallisation followed by simultaneous agglomeration of the drug with the aid of a good solvent and /or a bridging liquid and a bad solvent. It is also possible to incorporate other drugs (to get a combination tablet), excipients (e.g. disintegrants for fast dissolving tablets) and different polymer combinations (to modify the drug release properties). In the recent years,attempts were made to produce Crystallo co agglomerates of various drugs, whichwere briefly discussed in this article. Even though large scale applications of CCA is not yet made possible, this technique gives a new line of opportunities to the tablet manufacturing process, ensuring low cost, single stepped production of particles with good micromeritic and mechanical characters which can be directly compressed.

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Improved flowability and compactibility of spherically agglomerated crystals of ascorbic acid for direct tableting designed by spherical crystallization process

Cited by 123 publications

References 5 publications

Role of excipients in the crystallization of Albendazole

Role of excipients in the crystallization of Albendazole

Effect of Additives on the Physicochemical and Drug Release Properties of Pioglitazone Hydrochloride Spherical Agglomerates

Crystallo – Co - Agglomeration: An Innovative Technique for Size Enlargement and Improved Flow Properties of Powders

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