Improved dispersion of SiC whisker in nano hydroxyapatite and effect of atmospheres on sintering of the SiC whisker reinforced nano hydroxyapatite composites

Zhao, Xueni; Yang, Junhong; Hua, Xueming; Wang, Xudong; Zhang, Li; He, Fuzhen; Liu, Qingyao; Zhang, Weigang

doi:10.1016/j.msec.2018.05.003

Cited by 23 publications

(7 citation statements)

References 38 publications

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“…In general, vacuum sintering and atmosphere sintering (typically Ar atmosphere) are used to prevent adverse reactions between different components. For example, the sintering of HA/Ti composites is usually carried out in an argon atmosphere to prevent the oxidation of Ti. − Moreover, sintering atmosphere has been proved to have a great influence on the properties of the composites. , Obviously, it is essential to evaluate the effect of atmosphere on the sintering process of HA/Ta composites, which has not yet been reported systematically.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Hydroxyapatite/Tantalum Composites by Pressureless Sintering in Different Atmosphere

Cai

Wang

et al. 2021

ACS Omega

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The effect of sintering atmosphere (air and Ar) and temperature (1100, 1200, 1300 °C) on the microstructure, mechanical properties, and bioactivity of hydroxyapatite/tantalum (HA/Ta) composites were systematically investigated by pressureless sintering of the mixture of HA and Ta powders. It shows that the sintering atmosphere greatly impacts the phase composition and microstructure of the HA/Ta composites. The higher diffusion of atoms promotes shrinkage and causes deeper reaction fusion between the HA matrix and Ta, which improved the interfacial binding of the HA/Ta composites. The refined grain structure and improved interfacial binding obtained within the Ar atmosphere compared to the air atmosphere benefit the mechanical properties. The maximum bending strength and shrinkage observed for the composites sintered at 1300 °C in the Ar atmosphere are 27.24 MPa and 6.65%, respectively. The cell counting kit-8 (CCK-8) method was used to investigate the in vitro cytocompatibility of HA/Ta composites. The results revealed that the HA/Ta composites sintered with different conditions have no cytotoxicity. The simulated body fluid (SBF) soaking results showed that all of the studied composites possess desirable bioactivity, as demonstrated by their ability to form calcium-deficient carbonate apatite layer on the surfaces. For composites sintered at 1300 °C, the surface apatite layer coverage of the composites obtained in the Ar atmosphere was increased by 139.7% than the ones obtained in air, which confirmed an enhanced bioactive mineralization ability. The results indicated that the HA/Ta composites sintered at 1300 °C in Ar possess desirable mechanical properties and bioactivity. This work opens up the new possibility for preparing HA-based composites and is of great value in biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Fabrication of Hydroxyapatite/Tantalum Composites by Pressureless Sintering in Different Atmosphere

Cai

Wang

et al. 2021

ACS Omega

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“…The biofunctionality and in vitro abilities of HAp can be adjusted by controlling its phase, structure, composition, and morphology. One way to achieve this is by incorporating/adding different elements such as F [11], Mg [12][13][14][15][16][17], Zn [12,[17][18][19][20][21], Ag [16,19,22], Sr [13,17,23], and Si [24][25][26][27][28][29] into the HAp structure, which is very flexible. A considerable number of scientific papers related to the substitution of HAp with various elements can be found in the literature, indicating that this is an important path in the biomaterial and medical fields.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Activity Assays of Sputtered HAp Coatings with SiC Addition in Various Simulated Biological Fluids

et al. 2019

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Considering the requirements of medical implantable devices, it is pointed out that biomaterials should play a more sophisticated, longer-term role in the customization and optimization of the material–tissue interface in order to ensure the best long-term clinical outcomes. The aim of this contribution was to assess the performance of silicon carbide–hydroxyapatite in various simulated biological fluids (Dulbecco’s modified Eagle’s medium (DMEM), simulated body fluid (SBF), and phosphate buffer solution (PBS)) through immersion assays for 21 days at 37 ± 0.5 °C and to evaluate the electrochemical behavior. The coatings were prepared on Ti6Al4V alloy substrates by magnetron sputtering method using two cathodes made of hydroxyapatite and silicon carbide (SiC). After immersion assays the coating’s surface was analyzed in terms of morphology, chemical and phase composition, and chemical bonds. According to the electrochemical behavior in the media investigated at 37 ± 0.5 °C, SiC addition inhibits the dissolution of the hydroxyapatite in DMEM acellular media. Furthermore, after adding SiC, the slow degradation of hydroxyapatite in PBS and SBF media as well as biomineralization in DMEM were observed.

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“…The toughness and flexibility of bone tissue can be ascribed to the complex biomineralization of collagen fibers with apatitic crystals, associated to the multi-scale hierarchical architecture [168]. The toughness of bioceramics can be improved by including additional biocompatible phases [169,170], crack bridging, or phase transformation, in order to control the crack growth [171][172][173].The dispersion of second phase such as fibers, whiskers, and particles for creating toughness in bioceramics was also reported [174][175][176][177].…”

Section: Mechanical Propertiesmentioning

confidence: 99%

“…Semi-finished processing techniques for bioceramic composites involve a myriad of techniques, including hand layup, spray up, injection molding, resign transfer molding, compression molding, filament winding, and pultrusion, according to the type of filler (particles, whiskers, and fibers) [175,176].…”

Section: Processing Approaches Towards Ceramic Tougheningmentioning

confidence: 99%

Toughening of Bioceramic Composites for Bone Regeneration

et al. 2021

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Bioceramics are widely considered as elective materials for the regeneration of bone tissue, due to their compositional mimicry with bone inorganic components. However, they are intrinsically brittle, which limits their capability to sustain multiple biomechanical loads, especially in the case of load-bearing bone districts. In the last decades, intense research has been dedicated to combining processes to enhance both the strength and toughness of bioceramics, leading to bioceramic composite scaffolds. This review summarizes the recent approaches to this purpose, particularly those addressed to limiting the propagation of cracks to prevent the sudden mechanical failure of bioceramic composites.

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Improved dispersion of SiC whisker in nano hydroxyapatite and effect of atmospheres on sintering of the SiC whisker reinforced nano hydroxyapatite composites

Cited by 23 publications

References 38 publications

Fabrication of Hydroxyapatite/Tantalum Composites by Pressureless Sintering in Different Atmosphere

Fabrication of Hydroxyapatite/Tantalum Composites by Pressureless Sintering in Different Atmosphere

In Vitro Activity Assays of Sputtered HAp Coatings with SiC Addition in Various Simulated Biological Fluids

Toughening of Bioceramic Composites for Bone Regeneration

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