Improved Detection of Second Primary Cancer Using Integrated [<sup>18</sup>F] Fluorodeoxyglucose Positron Emission Tomography and Computed Tomography for Initial Tumor Staging

Choi, Joon Young; Lee, Kyung Soo; Kwon, O Jung; Shim, Young Mog; Baek, Chung‐Hwan; Park, Keunchil; Lee, Kyung-Han; Kim, Byung‐Tae

doi:10.1200/jco.2005.01.4340

Cited by 114 publications

(94 citation statements)

References 11 publications

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“…PET has been particularly helpful in the evaluation of patients with nodal disease and with a clinically unknown primary for directing biopsies of clinically occult primary lesions, determining N stage, differentiating recurrent tumor from posttherapy changes, monitoring or predicting treatment response, and detecting second primary lesions as well as distant metastases (1,(6)(7)(8)(9)(10)(11)(12). The PET/CT scan offers advantages over a PET scan alone, which is limited by poor anatomic localization, and a CT scan alone, which provides morphologic data only.…”

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confidence: 99%

Tumor Volume Assessment by¹⁸F-FDG PET/CT in Patients with Oral Cavity Cancer with Dental Artifacts on CT or MR Images

Baek¹,

Chung²,

Son³

et al. 2008

J Nucl Med

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The purpose of this study was to investigate the clinical usefulness of PET/CT or CT-attenuated PET in the evaluation of patients with oral cavity cancer (OCC) in whom dental artifacts distorted the conventional CT or MR images of the oral cavity. Methods: A PET/CT scan, in addition to a CT or MRI scan, was performed in 69 patients with OCC who had dentures or dental implants. A total of 64 PET/CT, 64 CT, and 27 MR images were analyzed including images from scans performed on 40 patients with OCC without dental artifacts on the conventional images; these were used for comparison. The CT-attenuated PET scan for the detection of primary tumors was compared with the CT or MRI scan. We also evaluated the correlation between the PET/CT volume and the pathologic volume using a regression analysis. In addition, subgroup analysis was performed to determine what proportion of subjects benefited most from the PET/CT. Results: CT-attenuated PET detected more primary tumors than did CT in patients with OCC with dental artifacts (95.3% vs. 75.0%, respectively; P 5 0.0016). PET/CT volume with a standardized uptake value (SUV) cutoff point of 3.5 predicted the pathologic volume more accurately than did the other cutoff points in patients with OCC with or without artifacts. After comparing pathologic volume and PET/CT SUV 3.5 volume, the following regression equation was developed: log (pathologic volume) 5 0.6 · log (PET/CT SUV 3.5 volume) 1 1.3 (R 2 5 0.42, P , 0.0001). Subgroup analysis showed that the prediction of the pathologic volume from the PET/CT images was more reliable for tumors that were more than 2 cm in depth (R 2 5 0.72). Conclusion: For patients with OCC with dental artifacts on the conventional imaging, PET/CT could provide useful clinical information about the primary tumors, particularly in cases with advanced tumors.

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confidence: 99%

Tumor Volume Assessment by¹⁸F-FDG PET/CT in Patients with Oral Cavity Cancer with Dental Artifacts on CT or MR Images

Baek¹,

Chung²,

Son³

et al. 2008

J Nucl Med

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“…NBI and LCE, along with conventional endoscopy, are recommended for the diagnosis of early oesophageal cancer and to evaluate the potential of developing SPM in patients with HSCC. On the other hand, several studies have reported the usefulness of fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) for the detection of SPM (13,14). Although FDG-PET/CT is useful for detecting multiple SPMs, the reliability of this modality's ability to identify early oesophageal cancer is unclear; moreover, the sensitivity of FDG-PET/CT for detecting synchronous oesophageal cancer is reported to be relatively low (15,16).…”

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confidence: 99%

Clinical and Prognostic Analysis of Hypopharyngeal Squamous Cell Carcinoma with Synchronous and Metachronous Multiple Malignancies

Yamamoto

Takano

Kondo

et al. 2018

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Abstract. Background Hypopharyngeal squamous cell carcinoma (HSCC) exhibits clinical manifestations that are different from other head and neck cancers. While it is less prevalent than other head and neck SCCs, accounting for 3-5% of all such malignancies, it carries a very poor prognosis (1-3). High mortality due to HSCC is caused not only by the high rates of nodal and early systemic metastases at presentation or during follow-up, but also the occurrence of second primary malignancies (SPMs) that are identified either simultaneously with the primary lesion (synchronous) or a period of time thereafter (metachronous). A recent study found that 17% of 2,063 patients with head and neck cancer involved SPMs, and that the overall survival rates of these patients were significantly lower than in those without SPMs (4). The head and neck, lung, and oesophagus are the most frequent areas of SPM development after an index head and neck cancer (4, 5). Many of the common risk factors for head and neck cancer, such as smoking, alcohol, aging, and poor oral hygiene, can increase the risk for SPM elsewhere in the body. Patients with HSCC in particular develop SPMs more frequently than those with other primary regions of head and neck cancer (5, 6); therefore, identifying the critical risk factors for this phenomenon is important for the earlier detection and prevention of multiple primary cancers. However, there have been few studies that focused on SPM in patients with HSCC. Hence, the present study aimed to analyse the clinical features and prevalence of synchronous and metachronous SPM in patients with HSCC, as well as to identify the risk factors associated with SPM occurrence and determine the causespecific mortality. Patients and MethodsPatients. A total of 136 patients (121 men and 15 women) with HSCC were diagnosed and treated between 2006 and 2015 at the

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“…The reported increased sensitivity of PET/CT over CT has been attributed to the ability of 18 F-FDG PET to detect metabolic abnormalities that precede the morphologic changes seen by CT. The global (skull base to proximal thighs) nature of PET/CT study also contributes to increased sensitivity through the detection of distant metastases in HCC patients [25,26] .…”

Section: Discussionmentioning

confidence: 99%

Highly metabolic thrombus of the portal vein: 18F fl uorodeoxyglucose positron emission tomography/computer tomography demonstration and clinical signifi cance in hepatocellular carcinoma

Sun¹,

Guan²,

Pan³

et al. 2008

WJG

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Improved Detection of Second Primary Cancer Using Integrated [¹⁸F] Fluorodeoxyglucose Positron Emission Tomography and Computed Tomography for Initial Tumor Staging

Cited by 114 publications

References 11 publications

Tumor Volume Assessment by¹⁸F-FDG PET/CT in Patients with Oral Cavity Cancer with Dental Artifacts on CT or MR Images

Tumor Volume Assessment by¹⁸F-FDG PET/CT in Patients with Oral Cavity Cancer with Dental Artifacts on CT or MR Images

Clinical and Prognostic Analysis of Hypopharyngeal Squamous Cell Carcinoma with Synchronous and Metachronous Multiple Malignancies

Highly metabolic thrombus of the portal vein: 18F fl uorodeoxyglucose positron emission tomography/computer tomography demonstration and clinical signifi cance in hepatocellular carcinoma

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Improved Detection of Second Primary Cancer Using Integrated [18F] Fluorodeoxyglucose Positron Emission Tomography and Computed Tomography for Initial Tumor Staging

Cited by 114 publications

References 11 publications

Tumor Volume Assessment by18F-FDG PET/CT in Patients with Oral Cavity Cancer with Dental Artifacts on CT or MR Images

Tumor Volume Assessment by18F-FDG PET/CT in Patients with Oral Cavity Cancer with Dental Artifacts on CT or MR Images

Clinical and Prognostic Analysis of Hypopharyngeal Squamous Cell Carcinoma with Synchronous and Metachronous Multiple Malignancies

Highly metabolic thrombus of the portal vein: 18F fl uorodeoxyglucose positron emission tomography/computer tomography demonstration and clinical signifi cance in hepatocellular carcinoma

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Improved Detection of Second Primary Cancer Using Integrated [¹⁸F] Fluorodeoxyglucose Positron Emission Tomography and Computed Tomography for Initial Tumor Staging

Tumor Volume Assessment by¹⁸F-FDG PET/CT in Patients with Oral Cavity Cancer with Dental Artifacts on CT or MR Images

Tumor Volume Assessment by¹⁸F-FDG PET/CT in Patients with Oral Cavity Cancer with Dental Artifacts on CT or MR Images