Improved antitumoral properties of pure antiestrogen RU 58668-loaded liposomes in multiple myeloma

Maillard, Sébastien; Gauduchon, Juliette; Marsaud, Véronique; Gouilleux, Fabrice; Connault, Elisabeth; Opolon, Paule; Fattal, Elias; Sola, Brigitte; Renoir, Jack‐Michel

doi:10.1016/j.jsbmb.2006.03.008

Cited by 19 publications

(34 citation statements)

References 51 publications

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“…5). Apoptosis signalling is amplified by the recruitment of caspase-8 and the cleavage of Bid (Maillard et al 2006), but does not require the extrinsic death receptor pathways mediated by Fas/FasL and DR4/5/TRAIL (our unpublished data).…”

Section: Effects Of Aes On the Apoptosis Of MM Cellsmentioning

confidence: 82%

“…ER ligands act in synergy with conventional molecules used in the treatment of cancer, such as dexamethasone, and bortezomib (Jordan 2007, Jordan & Brodie 2007, and encouraging preliminary results for MM xenografts (Maillard et al 2006) and MM patients (Fassas et al 2001) provide a rationale for the use of AEs in the clinical treatment of MM. AE compounds may be of greater value for the treatment than the original restriction of their use to E 2 -dependent BCs might suggest.…”

Section: Discussionmentioning

confidence: 99%

“…This type of tumour preserves neo-angiogenic characteristics necessary for the development of the disease. Using a stealth liposomal delivery system, we have demonstrated that both RU (Maillard et al , 2006 and 4-HT (manuscript in preparation) induced a decrease of RPMI 8226 tumour growth. In addition, AE-targeted to solid tumours by delivery systems such as those generated for RPMI 8226 (Maillard et al 2006) and MCF-7 xenografts induce strong anti-angiogenesis, potentiating the anti-proliferative and apoptotic activities of AEs .…”

Section: Effects Of Aes In MM Xenograftsmentioning

confidence: 98%

“…3; Otsuki et al 2000), together with protein isoforms (Treon et al 1998, Maillard et al 2006, Olivier et al 2006. However, these proteins are expressed in small amounts and are difficult to detect by immunoblotting.…”

Section: Effects Of Oestrogens and Aes In MM Expression Of Oestrogen mentioning

confidence: 99%

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Antioestrogen-mediated cell cycle arrest and apoptosis induction in breast cancer and multiple myeloma cells

Renoir

Bouclier

Seguin

et al. 2008

Journal of Molecular Endocrinology

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Antioestrogens (AEs) are synthetic molecules that block proliferation and induce apoptosis in breast cancer (BC) cells, principally by competing with oestradiol for binding to oestrogen receptors. Their antiproliferative activity and their proapoptotic capacity are well documented and a small number of molecules of this class are currently used clinically for the treatment of BC. AEs also inhibit cell cycle progression and/or induce apoptosis in multiple myeloma (MM) cells. Encouraging preliminary results have been obtained with patients and on xenografts with MM, providing a rational basis for the clinical use of AEs. This review focuses on antioestrogen-mediated signalling for blocking targets involved in the cell cycle, survival and apoptosis in both BC and MM cells. Improvement in our understanding of the mechanisms underlying the relationships between these compounds and their targets should lead to more beneficial therapeutic strategies.

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Section: Effects Of Aes On the Apoptosis Of MM Cellsmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Effects Of Aes In MM Xenograftsmentioning

confidence: 98%

Section: Effects Of Oestrogens and Aes In MM Expression Of Oestrogen mentioning

confidence: 99%

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Antioestrogen-mediated cell cycle arrest and apoptosis induction in breast cancer and multiple myeloma cells

Renoir

Bouclier

Seguin

et al. 2008

Journal of Molecular Endocrinology

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“…Plassat et al (2008) showed that the liposomes, sterically stabilized by hydrophilic chains of polyethylene glycol and encapsulating superparamagnetic maghemite γ-Fe 2 O 3 nanocrystals, can be exploited to target breast cancer tumours. This exploitation is possible by applying an external magnetic field gradient at the region of interest, and by associating the nanohybrids to an antiestrogen (RU 58668), which is effective to stop the growth of estrogen-dependent tumours (Maillard et al, 2006).…”

Section: Magnetic Targeting For Site-specific Drug Deliverymentioning

confidence: 99%

Microwave synthesis of core-shell structured biocompatible magnetic nanohybrids in aqueous medium

Hu¹,

Percheron²,

Chaumont³

et al. 2011

Microwave Heating

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Anti‐Estrogen‐Loaded Superparamagnetic Liposomes for Intracellular Magnetic Targeting and Treatment of Breast Cancer Tumors

Plassat

Wilhelm

Marsaud

et al. 2010

Adv Funct Materials

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Improved antitumoral properties of pure antiestrogen RU 58668-loaded liposomes in multiple myeloma

Cited by 19 publications

References 51 publications

Antioestrogen-mediated cell cycle arrest and apoptosis induction in breast cancer and multiple myeloma cells

Antioestrogen-mediated cell cycle arrest and apoptosis induction in breast cancer and multiple myeloma cells

Microwave synthesis of core-shell structured biocompatible magnetic nanohybrids in aqueous medium

Anti‐Estrogen‐Loaded Superparamagnetic Liposomes for Intracellular Magnetic Targeting and Treatment of Breast Cancer Tumors

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