Improved antibacterial and antibiofilm activity of magnesium fluoride nanoparticles obtained by water-based ultrasound chemistry

Lellouche, Jonathan; Friedman, Alexandra; Lellouche, Jean‐Paul; Gedanken, Aharon; Banin, Ehud

doi:10.1016/j.nano.2011.09.002

Cited by 79 publications

(44 citation statements)

References 37 publications

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“…Disorder in the normal functioning of these processes decreases the ability of bacteria to form biofilms. 144 However, studies have shown that NPs can act on the ion channels in bacterial biofilms, thereby regulating the metabolic activity of bacteria. Salem et al 145 showed that the amounts of Ag NPs and ZnO NPs necessary for growth inhibition (minimal inhibitory concentration assay) and for inhibition of metabolic activity (INT assay) were nearly equal.…”

Section: Nps Inhibit the Formation Of Bacterial Biofilmsmentioning

confidence: 99%

The antimicrobial activity of nanoparticles: present situation and prospects for the future

Wang¹,

Hu²,

Shao³

2017

IJN

2,901

1,792

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Nanoparticles (NPs) are increasingly used to target bacteria as an alternative to antibiotics. Nanotechnology may be particularly advantageous in treating bacterial infections. Examples include the utilization of NPs in antibacterial coatings for implantable devices and medicinal materials to prevent infection and promote wound healing, in antibiotic delivery systems to treat disease, in bacterial detection systems to generate microbial diagnostics, and in antibacterial vaccines to control bacterial infections. The antibacterial mechanisms of NPs are poorly understood, but the currently accepted mechanisms include oxidative stress induction, metal ion release, and non-oxidative mechanisms. The multiple simultaneous mechanisms of action against microbes would require multiple simultaneous gene mutations in the same bacterial cell for antibacterial resistance to develop; therefore, it is difficult for bacterial cells to become resistant to NPs. In this review, we discuss the antibacterial mechanisms of NPs against bacteria and the factors that are involved. The limitations of current research are also discussed.

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Section: Nps Inhibit the Formation Of Bacterial Biofilmsmentioning

confidence: 99%

The antimicrobial activity of nanoparticles: present situation and prospects for the future

Wang¹,

Hu²,

Shao³

2017

IJN

2,901

1,792

View full text Add to dashboard Cite

show abstract

“…30 Our results revealed that NPs penetrate the cells, reduce the internal pH, cause disruption to the membrane potential, and enhance lipid peroxidation. 29,30 We utilized this new metal fluoride nanomaterial to coat glass slide coupons and showed that the coated surfaces can restrict bacterial colonization and biofilm formation for up to 7 days. 30 We also described the method for depositing MgF 2 NPs on latex-based catheters in a one-step process and for obtaining a long-lasting MgF 2 NP coating, even following exposure to various biological fluids, such as artificial urine and plasma.…”

mentioning

confidence: 62%

“…28 Our group has recently demonstrated the antibacterial and antibiofilm properties of highly crystalline, 25 nm-sized magnesium fluoride (MgF 2 ) nanoparticles (NPs) using different chemistries for their synthesis. 29,30 Antimicrobial activity of MgF 2 NPs was highly dependent on the size of the NP. 30 Our results revealed that NPs penetrate the cells, reduce the internal pH, cause disruption to the membrane potential, and enhance lipid peroxidation.…”

mentioning

confidence: 99%

“…29,30 Antimicrobial activity of MgF 2 NPs was highly dependent on the size of the NP. 30 Our results revealed that NPs penetrate the cells, reduce the internal pH, cause disruption to the membrane potential, and enhance lipid peroxidation. 29,30 We utilized this new metal fluoride nanomaterial to coat glass slide coupons and showed that the coated surfaces can restrict bacterial colonization and biofilm formation for up to 7 days.…”

mentioning

confidence: 99%

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Antibacterial and antibiofilm properties of yttrium fluoride nanoparticles

Lellouche¹,

Friedman²,

Gedanken³

et al. 2012

IJN

Self Cite

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Antibiotic resistance has prompted the search for new agents that can inhibit bacterial growth. Moreover, colonization of abiotic surfaces by microorganisms and the formation of biofilms is a major cause of infections associated with medical implants, resulting in prolonged hospitalization periods and patient mortality. In this study we describe a water-based synthesis of yttrium fluoride (YF 3 ) nanoparticles (NPs) using sonochemistry. The sonochemical irradiation of an aqueous solution of yttrium (III) acetate tetrahydrate [Y(Ac) 3 ⋅ (H 2 O) 4 ], containing acidic HF as the fluorine ion source, yielded nanocrystalline needle-shaped YF 3 particles. The obtained NPs were characterized by scanning electron microscopy and X-ray elemental analysis. NP crystallinity was confirmed by electron and powder X-ray diffractions. YF 3 NPs showed antibacterial properties against two common bacterial pathogens (Escherichia coli and Staphylococcus aureus) at a µg/mL range. We were also able to demonstrate that antimicrobial activity was dependent on NP size. In addition, catheters were surface modified with YF 3 NPs using a one-step synthesis and coating process. The coating procedure yielded a homogeneous YF 3 NP layer on the catheter, as analyzed by scanning electron microscopy and energy dispersive spectroscopy. These YF 3 NP-modified catheters were investigated for their ability to restrict bacterial biofilm formation. The YF 3 NP-coated catheters were able to significantly reduce bacterial colonization compared to the uncoated surface. Taken together, our results highlight the potential to further develop the concept of utilizing these metal fluoride NPs as novel antimicrobial and antibiofilm agents, taking advantage of their low solubility and providing extended protection.

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“…If the volume of accumulated H 2 reaches a high level, it will cause separation of tissue and tissue layers [4][5][6][7] . Consequently, in order to decrease their degradation rate and thus accumulation of H 2 to match the healing rate of damaged bones, fluoride conversion film (FCF) has been developed, attributed to the harmlessness of the fluorine ions releasing into the organism [8] , its good biotissue compatibility [9][10][11][12] , excellent cell adhesion [13][14] , and its characteristics to accelerate the osseointegration rate [15] , enhance bone healing [16] and prevent the biofilm formation [17][18][19] . The original method to fabricate FCF on Mg substrate was immersion of Mg substrate in 40% or 48% hydrofluoric acid, HF [19][20][21][22][23][24][25] , however, the high toxicity…”

Section: Introductionmentioning

confidence: 99%

Influence of The KF Concentration on The Coating Process And Properties of Potentiostatic Deposited Fluoride Conversion Film on AZ31 Mg Alloy

Dong¹

2015

Res. Rev. J Mat. Sci

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The dependence of coating process and properties of the fluoride conversion film on AZ31 Mg alloy on the concentration of deaerated KF solutions was studied by anodic potentiostatic deposition, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and electrochemical impedance spectroscopy (EIS). The results show that the film deposited in 0.05 M KF solution is a monolayer consisting of amorphous Mg(OH) 2 and MgF 2 , while amorphous Mg(OH) 2 and MgF 2 and crystallized KMgF 3 as a double layer formed in 0.1 M~0.5 M KF solutions. The composition of inner layer is same as that of the monolayer, while the outer layer is composed of Mg(OH) 2 and MgF 2 and KMgF 3 . Continually increasing KF concentration reduces the content of KMgF 3 in the outer layer, shortens the coating duration, and reduces the film thickness. The corrosion resistance of FCF coatings is closely correlated with the content of KMgF 3 and the film thickness.

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Improved antibacterial and antibiofilm activity of magnesium fluoride nanoparticles obtained by water-based ultrasound chemistry

Cited by 79 publications

References 37 publications

The antimicrobial activity of nanoparticles: present situation and prospects for the future

The antimicrobial activity of nanoparticles: present situation and prospects for the future

Antibacterial and antibiofilm properties of yttrium fluoride nanoparticles

Influence of The KF Concentration on The Coating Process And Properties of Potentiostatic Deposited Fluoride Conversion Film on AZ31 Mg Alloy

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