Antibacterial and antibiofilm properties of yttrium fluoride nanoparticles

Abstract

Antibiotic resistance has prompted the search for new agents that can inhibit bacterial growth. Moreover, colonization of abiotic surfaces by microorganisms and the formation of biofilms is a major cause of infections associated with medical implants, resulting in prolonged hospitalization periods and patient mortality. In this study we describe a water-based synthesis of yttrium fluoride (YF 3 ) nanoparticles (NPs) using sonochemistry. The sonochemical irradiation of an aqueous solution of yttrium (III) acetate tetrahydrate [Y(Ac) 3 ⋅ (H 2 O) 4 ], containing acidic HF as the fluorine ion source, yielded nanocrystalline needle-shaped YF 3 particles. The obtained NPs were characterized by scanning electron microscopy and X-ray elemental analysis. NP crystallinity was confirmed by electron and powder X-ray diffractions. YF 3 NPs showed antibacterial properties against two common bacterial pathogens (Escherichia coli and Staphylococcus aureus) at a µg/mL range. We were also able to demonstrate that antimicrobial activity was dependent on NP size. In addition, catheters were surface modified with YF 3 NPs using a one-step synthesis and coating process. The coating procedure yielded a homogeneous YF 3 NP layer on the catheter, as analyzed by scanning electron microscopy and energy dispersive spectroscopy. These YF 3 NP-modified catheters were investigated for their ability to restrict bacterial biofilm formation. The YF 3 NP-coated catheters were able to significantly reduce bacterial colonization compared to the uncoated surface. Taken together, our results highlight the potential to further develop the concept of utilizing these metal fluoride NPs as novel antimicrobial and antibiofilm agents, taking advantage of their low solubility and providing extended protection.

Environmentally Friendly Chitosan Biopolymer and its Anti-biofilm Activity”

“…Biofilm formation with nanoparticles is prevented by designing the surfaces to prevent limited bacterial colonization. 17 Bacterial attachment and biofilm formation is inhibited by coating, impregnation, or embossing nanomaterial surfaces by nano-functionalization. 17 Thus, nanoparticles have emerged as a new field of struggle against biofilms.…”

“…17 Bacterial attachment and biofilm formation is inhibited by coating, impregnation, or embossing nanomaterial surfaces by nano-functionalization. 17 Thus, nanoparticles have emerged as a new field of struggle against biofilms. 18 There are several studies on the antimicrobial and antibiotic activities of silver nanoparticles, and it has been reported that such nanomaterials can be used in the production of medical biomaterials.…”

Antibacterial potential associated with drug-delivery built TiO2 nanotubes in biomedical implants

“…aeruginosa, Serratia marcescens Inhibition of bacterial growthKannan and Sundrarajan (2015), Lee et al (2018)YF 3 E . coli , S. aureus Reduction of bacterial colonization on YF 3 coated-surface and antibiofilm activitiesLellouche et al (2012a, b), Hemeg (2017)CdS E . coli Antibiofilm activityDhanabalan and Gurunathan (2015), Hemeg (2017)MgF 2 E .…”

“…coli , S . aureus Inhibition of biofilm formation; ROS generation, lipid peroxidation and penetration of cell envelopeLellouche et al (2012a, b), Hemeg (2017)Bi S . mutans Reduction of bacterial growth; inhibition of biofilm formationHernandez-Delgadillo et al (2012), Hemeg (2017) NPs nanoparticles, ROS reactive oxygen species…”

Effects of surface functionalization of hydrophilic NaYF4 nanocrystals doped with Eu3+ on glutamate and GABA transport in brain synaptosomes

“…Yttrium NCs can be applied in drug release and targeted cancer cell ablation (Xu et al 2012 ). The YF(3) NC-coated catheters were able to significantly reduce bacterial colonization (Lellouche et al 2012 ).…”