Improved anti-colorectal carcinomatosis effect of tannic acid co-loaded with oxaliplatin in nanoparticles encapsulated in thermosensitive hydrogel

Ren, Yaoyao; Li, Xiaoling; Han, Bo; Zhao, Na; Mu, Mingchun; Wang, Chao; Du, Ying; Wang, Yuelong; Tong, Aiping; Liu, Yi; Zhou, Liangxue; You, Chao; Guo, Gang

doi:10.1016/j.ejps.2018.12.007

Cited by 68 publications

(37 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In another study, an injectable drug delivery system was developed, involving oxaliplatin (OXA) and TA incorporated into polymeric nanoparticles in a form of a thermo-sensitive hydrogel, (OXA/TA NPs-H). Intraperitoneal application of OXA/TA NPs-H restricted the growth of CT26 peritoneal colon cancer in vivo, improved the quality of life, and prolonged the survival time of the model mice, which suggests this drug delivery system can be applied in colorectal cancer treatment [67].…”

Section: Tannic Acid As a Carrier Of Anticancer Drugsmentioning

confidence: 95%

“…TA possesses additive feature due to its low viscosity, good water solubility, and biocompatibility. TA can bind to drug molecules via hydrophobic interactions, which in turn form a self-assembled cross-linked network [67]. Such approach was used to generate TApaclitaxel (PTX) selfassembly nanoparticles (TAP NPs) in order to potentiate PTX chemotherapeutic efficiency.…”

Section: Tannic Acid As a Carrier Of Anticancer Drugsmentioning

confidence: 99%

See 1 more Smart Citation

Tannic Acid: Specific Form of Tannins in Cancer Chemoprevention and Therapy-Old and New Applications

et al. 2020

View full text Add to dashboard Cite

Purpose of Review This short review is aimed at providing an updated and comprehensive report on tannic acid biological activities and molecular mechanisms of action most important for cancer prevention and adjuvant therapy. Recent Findings Tannic acid (TA), a mixture of digallic acid esters of glucose, is a common ingredient of many foods. The early studies of its anti-mutagenic and anti-tumorigenic activity were mostly demonstrated in the mouse skin model. This activity has been explained by its ability to inhibit carcinogens activation, as well as antioxidant and anti-inflammatory properties. Recently, the cell cycle arrest, apoptosis induction, reduced rate of proliferation, and cell migration and adhesion of several cancer cell lines as a result of TA treatment were described. The underlining mechanisms include modulation of signaling pathways such as EGFR/Jak2/STATs, or inhibition of PKM2 glycolytic enzyme. Moreover, epithelial-to-mesenchymal transition prevention and decrease of cancer stem cells formation by TAwere also reported. Besides, TAwas found to be potent chemosensitizer overcoming multidrug resistance. Eventually, its specific physicochemical features were found useful for generation of drug-loaded nanoparticles. Summary TA was shown to be a very versatile molecule with possible application not only in cancer prophylaxis, as was initially thought, but also in adjuvant cancer therapy. The latter may refer to chemosensitization and its application as a part of drug delivery systems. More studies are required to better explore this subject. In addition, the effect of TA on normal cells and its bioavailability have to better characterized.

show abstract

Section: Tannic Acid As a Carrier Of Anticancer Drugsmentioning

confidence: 95%

Section: Tannic Acid As a Carrier Of Anticancer Drugsmentioning

confidence: 99%

Tannic Acid: Specific Form of Tannins in Cancer Chemoprevention and Therapy-Old and New Applications

et al. 2020

View full text Add to dashboard Cite

show abstract

“…To deal with colorectal cancer (CRC), one of the most malignant tumors that originates from colon and rectum, which severely affects public health, 130 the collaborative DDS containing more than two drugs is well worth studying. Oxaliplatin (OXA)/tannic acid (TA) nanoparticles‐hydrogel 131 was demonstrated favorable antiangiogenesis and anticancer function based on the synergistic effect of OXA and TA. In animal experiment, OXA/TA NPs‐hydrogel effectively controlled the CT26 peritoneal colon tumor nodular size, and the result of a prolonged life span of mice was also strong proof supporting future hydrogel intraperitoneal anticancer application.…”

Section: The Application Of Hydrogels In Localized Tumor Treatmentmentioning

confidence: 99%

Advances and trends of hydrogel therapy platform in localized tumor treatment: A review

Tan

Huang

et al. 2020

J Biomedical Materials Res

View full text Add to dashboard Cite

Due to limitations of treatment and the stubbornness of infiltrative tumor cells, the outcome of conventional antitumor treatment is often compromised by a variety of factors, including severe side effects, unexpected recurrence, and massive tissue loss during the treatment. Hydrogel‐based therapy is becoming a promising option of cancer treatment, because of its controllability, biocompatibility, high drug loading, prolonged drug release, and specific stimuli‐sensitivity. Hydrogel‐based therapy has good malleability and can reach some areas that cannot be easily touched by surgeons. Furthermore, hydrogel can be used not only as a carrier for tumor treatment agents, but also as a scaffold for tissue repair. In this review, we presented the latest researches in hydrogel applications of localized tumor therapy and highlighted the recent progress of hydrogel‐based therapy in preventing postoperative tumor recurrence and improving tissue repair, thus proposing a new trend of hydrogel‐based technology in localized tumor therapy. And this review aims to provide a novel reference and inspire thoughts for a more accurate and individualized cancer treatment.

show abstract

“…29 Tannic acid could reverse OXA resistance in CRC cells, which was consistent with our study. 30 However, the mechanism underlying the chemo-preventive effect of Tan IIA has not been fully demonstrated. Several studies have demonstrated that activation of Akt and ERK signaling pathways could directly induce drug resistance.…”

Section: Dovepressmentioning

confidence: 99%

<p>Tanshinone IIA Reverses Oxaliplatin Resistance In Human Colorectal Cancer Via Inhibition Of ERK/Akt Signaling Pathway</p>

Zhang¹,

Ge²,

Xiang³

et al. 2019

OTT

View full text Add to dashboard Cite

Background: Oxaliplatin (OXA)-based chemotherapy is generally used to treat human cancers, whereas OXA resistance is a main obstacle for the treatment of colorectal cancer (CRC). Evidence has shown that tanshinone IIA (Tan IIA) could induce apoptosis in CRC cells. However, the role of combination of OXA and Tan IIA on OXA-resistance CRC cells remains unknown. Thus, this study aimed to investigate the effects of Tan IIA in combination with OXA on OXA-resistance CRC cells. Methods: MTT assay, Ki67 immunofluorescence staining and flow cytometry were used to detect viability, proliferation and apoptosis in OXA-resistant cell line SW480/OXA, respectively. The expressions of Bcl-2, Bax, active caspase 3, p-Akt and pERK in SW480/OXA cells were detected with Western blot. In vivo animal study was performed finally. Results: In this study, the inhibitory effects of OXA on the proliferation and invasion of SW480/ OXA cells were significantly enhanced by Tan IIA. In addition, Tan IIA obviously enhanced the anti-apoptosis effects of OXA on SW480/OXA cells via decreasing the levels of Bcl-2, p-Akt and pERK , and increasing the levels of Bax and active caspase 3. In vivo experiments confirmed that Tan IIA enhanced OXA sensitivity in SW480/OXA xenograft model. Conclusion: We found that Tan IIA could reverse OXA resistance in OXA-resistance CRC cells. Therefore, OXA combined with Tan IIA might be considered as a therapeutic approach for the treatment of OXA-resistant CRC.

show abstract

Improved anti-colorectal carcinomatosis effect of tannic acid co-loaded with oxaliplatin in nanoparticles encapsulated in thermosensitive hydrogel

Cited by 68 publications

References 38 publications

Tannic Acid: Specific Form of Tannins in Cancer Chemoprevention and Therapy-Old and New Applications

Tannic Acid: Specific Form of Tannins in Cancer Chemoprevention and Therapy-Old and New Applications

Advances and trends of hydrogel therapy platform in localized tumor treatment: A review

<p>Tanshinone IIA Reverses Oxaliplatin Resistance In Human Colorectal Cancer Via Inhibition Of ERK/Akt Signaling Pathway</p>

Contact Info

Product

Resources

About