Improved anti-arthritic activity of ginger extract, a traditional medicine, using novel drug delivery approach

Abstract

BackgroundGinger and castor oil, both are used in traditional medicine to treat arthritis, the latter is also commonly used as a vehicle in these systems of medicine. The study was designed to prepare a nanostructured lipid carrier (NLC) of ginger extract using castor oil as a novel liquid lipid and evaluate its safety and efficacy in rheumatoid arthritis in experimental animals.MethodsGinger extract was standardized using High performance liquid chromatography (HPLC). The optimized NLC formulation was characterized and its therapeutic efficacy was evaluated in Chronic Freund's adjuvant (CFA) induced arthritis in experimental animals.ResultsGinger extract contained 38.76 ± 3.01%w/w of 6-gingerol. The optimized NLC formulation showed a particle size of around 205 nm, a zeta potential of −33.7 and %entrapment efficiency of 76.59 ± 0.83%. Reduction in primary inflammation was significantly higher with NLC when compared with ginger extract and castor oil alone (p<0.001). The formulation also improved hyperalgesia in rats.ConclusionCastor oil can be used as a novel lipid in the preparation of NLC. The NLC effectively enhanced the therapeutic value of poorly bioavailable ginger extract.

Zingiber Officinale Roscoe: The Antiarthritic Potential of a Popular Spice—Preclinical and Clinical Evidence

“…On the other hand, various forms of oral administration, such as nanostructured lipid carriers, have also been analyzed [ 115 ]. For this purpose, an alcoholic extract of ginger containing 38.76 ± 3.01% w / w of 6-gingerol was incorporated into NLC and administered orally to rats with Chronic Freund’s adjuvant (CFA)-induced arthritis.…”

An Overview of the Spices Used for the Prevention and Potential Treatment of Gastric Cancer

“…An increase in the absorption of compounds contained in ginger extract can be achieved using the solid dispersion method [136]. Another option is to use castor oil as a nanostructured lipid carrier, which improves the bioavailability of ginger extract [137]. Ginger is described as safe to use and does not cause side effects [135].…”

Ginger (Zingiber officinale Roscoe) as a nutraceutical: Focus on the metabolic, analgesic, and antiinflammatory effects

“…Specifically, a ginger ethanol extract dose‐dependently and significantly reduced the reaction times in the hot plate test and inhibited acetic acid–induced writhes in mice (Ojewole, 2006). Furthermore, there is evidence that nanostructured lipid carrier of ginger extract using castor oil improves the analgesic effect of poorly available ginger extract (Londhe, Khogta, & Barve, 2020). The analgesic effects of ginger are believed to be exerted both peripherally and centrally, and they are mediated via COX/5‐LOX inhibition (in the periphery) and via central pain receptors in the central nervous system (Ojewole, 2006).…”