Ginger (<i>Zingiber officinale</i> Roscoe) as a nutraceutical: Focus on the metabolic, analgesic, and antiinflammatory effects

Pagano, Ester; Souto, Eliana B.; Durazzo, Alessandra; Sharifi‐Rad, Javad; Lucarini, Massimo; Souto, Selma B.; Salehi, Bahare; Zam, Wissam; Montanaro, Vittorino; Lucariello, Giuseppe; Izzo, Angelo A.; Santini, Antonello; Romano, Barbara

doi:10.1002/ptr.6964

Cited by 36 publications

(39 citation statements)

References 95 publications

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“…Among the biologically active compounds of terpenes, gingerols are the most abundant [ 13 ], with 6-gingerols containing a high amount [ 14 ]: analytical analyses determined that the amount of 6-gingerols was between 57.67 and 62.64 mg/g of rhizome-methanol extract [ 15 ]. Gingerols are thermally labile at high temperatures and easily subject to dehydration to form shogaol.…”

Section: Ginger: Chemical Structure Properties and Therapeutic Potentialmentioning

confidence: 99%

“…It has been demonstrated that after steam extraction, ginger contains a small percentage of essential oil rich in sesquiterpene hydrocarbons such as zingiberene and also small amounts of monoterpenic hydrocarbons and oxygenated compounds. However, attention must be paid when selecting the drying method or the freshness of the ginger, because these can affect the chemical structure and so alter the efficacy of the resulting compound [ 13 ]. Indeed, the main sesquiterpene hydrocarbon compounds in ginger oil obtained from fresh rhizome were α-zingiberene (27–30%), α-curcumene (8–9%), β-sesquifellandrene (4.8%), and bisabolen (3.2%).…”

Section: Ginger: Chemical Structure Properties and Therapeutic Potentialmentioning

confidence: 99%

“…Gingerols are thermally labile at high temperatures and easily subject to hydration to form shogaol. Additionally, it has also been reported that conversion of gerols to shogaol induced by temperatures can be affected by the type of heat (dry or Among the biologically active compounds of terpenes, gingerols are the most abundant [13], with 6-gingerols containing a high amount [14]: analytical analyses determined that the amount of 6-gingerols was between 57.67 and 62.64 mg/g of rhizome-methanol extract [15]. Gingerols are thermally labile at high temperatures and easily subject to dehydration to form shogaol.…”

Section: Ginger: Chemical Structure Properties and Therapeutic Potentialmentioning

confidence: 99%

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Ginger, a Possible Candidate for the Treatment of Dementias?

et al. 2021

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As the human life expectancy increases, age-linked diseases have become more and more frequent. The worldwide increment of dementia cases demands medical solutions, but the current available drugs do not meet all the expectations. Recently the attention of the scientific community was attracted by natural compounds, used in ancient medicine, known for their beneficial effects and high tolerability. This review is focused on Ginger (Zingiber officinale) and explore its properties against Alzheimer’s Disease and Vascular Dementia, two of the most common and devastating forms of dementia. This work resumes the beneficial effects of Ginger compounds, tested in computational in vitro and in vivo models of Alzheimer’s Disease and Vascular Dementia, along with some human tests. All these evidences suggest a potential role of the compounds of ginger not only in the treatment of the disease, but also in its prevention.

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Section: Ginger: Chemical Structure Properties and Therapeutic Potentialmentioning

confidence: 99%

Section: Ginger: Chemical Structure Properties and Therapeutic Potentialmentioning

confidence: 99%

Section: Ginger: Chemical Structure Properties and Therapeutic Potentialmentioning

confidence: 99%

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Ginger, a Possible Candidate for the Treatment of Dementias?

et al. 2021

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“…Nanoparticles have recognizable activities against various mycotoxigenic fungi such as Bipolaris sorokiniana, Magnaporthe grisea, Botrytis cinerea, Candida albicans, C. tropicalis, Aspergillus spp., Fusarium spp., P. expansum, and Al. alternata [27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis and Anti-Mycotoxigenic Activity of Zingiber officinale Roscoe-Derived Metal Nanoparticles

Raafat

El-Sayed

2021

Molecules

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Mycotoxigenic fungi have attracted special attention due to their threat to food security and toxicity to human health. Aqueous extract of Zingiber officinale Roscoe was used as reducing and capping agent for the synthesis of silver (AgNPs), copper (CuNPs), and zinc oxide (ZnONPs) nanoparticles. UV-Visible spectra of the AgNPs, CuNPs, and ZnONPs showed absorption peaks at λmax 416 nm, 472 nm, and 372 nm, respectively. Zeta potential of AgNPs, CuNPs, and ZnONPs were −30.9, −30.4 and −18.4 mV, respectively. ZnONPs showed the highest activity against Aspergillus awamori ZUJQ 965830.1 (ZOI 20.9 mm and MIC 24.7 µg/mL). TEM micrographs of ZnONPs-treated A. awamori showed cracks and pits in the cell wall, liquefaction of the cytoplasmic content, making it less electron-dense. The sporulation and ochratoxin A production of A. awamori was inhibited by ZnONPs in a concentration-dependent pattern. The inhibition percentage of OTA were 45.6, 84.78 and 95.65% for 10, 15, 20 of ZnONPs/mL, respectively.

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“…The main active ingredient in ginger is a phenolic compound called gingerol. The composition contained in ginger is mostly used to treat nausea and vomiting in pregnant women in modern phytotherapy (Pagano et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

The Effectiveness of Fish Oil and Ginger Drink in Reducing Dysmenorrhea: A Meta Analysis

Novitasari

Pamungkasari

Prasetya

2021

J MATERN CHILD HEALTH

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Background: Dysmenorrhea causes 34-50% of women to be unable to work in the workplace and 40% of adolescent girls are absent from school. Fish oil and ginger are used as alternatives to NSAIDs, because although the use of NSAIDs is effective in reducing dysmenorrhea pain, they have side effects that are harmful to health after long-term conventional therapy. This study aims to estimate the magnitude of the effect of fish oil and ginger in reducing dysmenorrhea in women of reproductive age. Subjects and Method: This was a metaanalysis and systematic study. The articles used were obtained from PubMed, Science Direct, ProQuest, Springer Link, and Google Scholar. The inclusion criteria used were full text articles with Randomized Control Trial (RCT). The study subjects are women of productive age. The treatment given was the consumption of fish oil or ginger with a placebo comparison, dysmenorrhea assessment using standardized measuring instruments such as VAS, Cox, questionnaires, etc. Articles published in English. The PICO Research Problem are population= women of reproductive age, intervention= fish oil or ginger, comparison= placebo, and out-come= dysmenorrhea. The study was assessed using an effect size (Standardized Mean Difference). Meta analysis was performed using RevMan 5.3 with Random Effect Model. Results: A total of 14 articles were reviewed in a meta-analysis in this study. Meta-analysis of 6 articles showed that fish oil reduced dysmenorrhea pain in women of reproductive age higher than placebo (Standardized Mean Diffe-rence= -1.06; 95% CI= -1.76 to -0.36; p= 0.003). Meta-analysis of 8 articles showed that ginger reduced dysmenorrhea pain in women of childbearing age more than placebo (Standardized Mean Difference= -0.77; 95% CI= -1.26 to -0.27; p=0.002). Conclusion: Fish oil and ginger are effective in reducing dysmenorrhea pain in women of reproductive age.

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Ginger (Zingiber officinale Roscoe) as a nutraceutical: Focus on the metabolic, analgesic, and antiinflammatory effects

Cited by 36 publications

References 95 publications

Ginger, a Possible Candidate for the Treatment of Dementias?

Ginger, a Possible Candidate for the Treatment of Dementias?

Biosynthesis and Anti-Mycotoxigenic Activity of Zingiber officinale Roscoe-Derived Metal Nanoparticles

The Effectiveness of Fish Oil and Ginger Drink in Reducing Dysmenorrhea: A Meta Analysis

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