Improve ICG Based Photodynamic Properties Through Conjugation of ICG Into Nano-Graphene Oxide Against <i>Enterococcus faecalis</i>

Akbari, Tayebeh; Pourhajibagher, Maryam; Chiniforush, Nasim; Shahabi, Sima; Hosseini, Farzaneh; Bahador, Abbas

doi:10.5812/ajcmi.64624

Cited by 9 publications

(4 citation statements)

References 34 publications

(62 reference statements)

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“…The overall antimicrobial and anti-biofilm potential of GO-APTES-L CA-ICG was higher than PDI based on ICG (1000 μg mL −1 ) (47% and 21%, respectively). The authors verified that the composite GO-APTES-L CA-ICG with a higher incorporation of ICG (400 μg mL −1 ) after a total light dose irradiation of 31.2 J∙cm −2 showed a significantly greater reduction in the number of E. faecalis than PDI based on ICG alone (1000 μg mL −1 ) [ 190 ].…”

Section: Supports Based On Carbon Nanomaterialsmentioning

confidence: 91%

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

et al. 2018

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Microbial infection is a severe concern, requiring the use of significant amounts of antimicrobials/biocides, not only in the hospital setting, but also in other environments. The increasing use of antimicrobial drugs and the rapid adaptability of microorganisms to these agents, have contributed to a sharp increase of antimicrobial resistance. It is obvious that the development of new strategies to combat planktonic and biofilm-embedded microorganisms is required. Photodynamic inactivation (PDI) is being recognized as an effective method to inactivate a broad spectrum of microorganisms, including those resistant to conventional antimicrobials. In the last few years, the development and biological assessment of new photosensitizers for PDI were accompanied by their immobilization in different supports having in mind the extension of the photodynamic principle to new applications, such as the disinfection of blood, water, and surfaces. In this review, we intended to cover a significant amount of recent work considering a diversity of photosensitizers and supports to achieve an effective photoinactivation. Special attention is devoted to the chemistry behind the preparation of the photomaterials by recurring to extensive examples, illustrating the design strategies. Additionally, we highlighted the biological challenges of each formulation expecting that the compiled information could motivate the development of other effective photoactive materials.

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Section: Supports Based On Carbon Nanomaterialsmentioning

confidence: 91%

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

et al. 2018

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“…The results of their research showed a significant reduction in biofilm formation of E. faecalis in a group with NGO-ICG + laser (PDT) comparing with groups without PDT and control. They also confirmed that under irradiation NGO-ICG was more effective than ICG without carbon carrier despite that ICG concentration in NGO-ICG was 20% of that used in ICG [47,48].…”

Section: Reviewmentioning

confidence: 62%

“…(1) indocyanine green loaded on a nano-graphene oxide [47,48], (2) indocyanine green-loaded nanocarriers (NCs) including graphene oxide (GO), GO-carnosine (Car) and GO-Car/hydroxyapatite (HAp) [49], (3) zirconium(IV) phthalocyanine derivative loaded on reduced graphite oxide with silver nanoparticles [45].…”

Section: Graphene Family Materialsmentioning

confidence: 99%

Perspectives of using photodynamic therapy as antimicrobial therapy in endodontics

Piątek

Gerasymchuk

Korona-Głowniak

et al. 2021

Reviews in Medical Microbiology

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In times of multidrug resistance of bacteria, photodynamic therapy (PDT) seems to be promising in many fields of medicine, including endodontics, especially in the case of previous failures of root canal treatment and periapical lesions formation. PDT is based on the use of a light source and photosensitizers (PSs). Irradiation caused by the appropriately selected wavelength of light initiates the formation of singlet oxygen and/or free radicals, which provides the antimicrobial activity responsible for effective disinfection. In this manuscript, we compare the findings from all available papers of authors who perform their research in vivo. Despite the fact that they conducted their research in various ways, the results obtained in the course of these studies indicated an effective antibacterial effect of PDT in endodontic treatment. The second part of our work focuses on the perspectives of finding the best PSs that are used in PDT method with great expectations for materials based on graphene oxide as those which are not only carriers but also factors influencing the increase in the efficiency of the particles attached to them.

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“…In conclusion, the application of nGO as a new drug delivery system, in addition to the anti-bacterial property, offers other benefits such as cost beneficial outcomes due to using the lower dye concentration (less toxicity), and less tooth discoloration. The nGO/ICG-PDT could be proposed as a new approach to treat endodontic infections, alone or in combination with conventional root canal treatments [32] (Figure 3). Zheng et al [33] had successfully constructed the fluorescence image guided photothermal therapy reagents based on (WO+ICG) @PLGA) nanoparticles.…”

Section: C)mentioning

confidence: 99%